Publications by authors named "Willem A L van Otterlo"
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Synopsis of recent research by authors named "Willem A L van Otterlo"
- Willem A L VAN Otterlo's recent research emphasizes the role of novel compounds in drug discovery, particularly focusing on phytochemicals and their derivatives with anticancer properties, as evidenced by studies involving sphaeropsidin derivatives and the flavonol fisetin.
- His work also explores innovative synthetic methodologies, including nickel-catalyzed cross-coupling reactions and modifications to enhance the solubility and efficacy of antiproliferative agents based on rigidin and 7-deazahypoxanthine frameworks.
- Additionally, VAN Otterlo investigates the mechanisms of action of these compounds, demonstrating their potential to overcome apoptosis resistance in cancer cells while also addressing the challenges of chemical stability and biocompatibility in pharmacological applications.
