Effects of Hypoxia on Proliferation and Apoptosis of Osteosarcoma Cells.

Background: Hypoxia can happen during solid tumor growth including osteosarcoma. This study investigated the relationship of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) on osteosarcoma cell growth and apoptosis under hypoxic conditions.

Materials And Methods: Human osteosarcoma cells were cultured under normal or hypoxic conditions.