Publications by authors named "Will J Thompson"
Article Synopsis
- - The outer segment (OS) of photoreceptors is a specialized structure crucial for capturing light and triggering responses, but its protein makeup is not well understood due to purification challenges.
- - Researchers employed protein correlation profiling alongside label-free quantitative mass spectrometry to identify unique proteins in the OS plasma membrane, discovering that only five proteins matched known markers.
- - Among the findings, two proteins (TMEM67 and TMEM237) were newly linked to the OS plasma membrane, and embigin, a protein not previously identified in photoreceptors, was shown to work with a transporter (MCT1) to facilitate lactate movement across this membrane.
Purpose: In the interferon era of hepatitis C virus (HCV) therapies, genotype/subtype, cirrhosis, prior treatment failure, sex, and race predicted relapse. Our objective is to validate a targeted proteomics platform of 17 peptides to predict sustained virologic response (SVR).
Experimental Design: Stored plasma from three, open-label, trials of HIV/HCV-coinfected subjects receiving interferon-containing regimens is identified.
Signal sequence-encoding mRNAs undergo translation-dependent localization to the endoplasmic reticulum (ER) and at the ER are anchored via translation on Sec61-bound ribosomes. Recent investigations into the composition and membrane association characteristics of ER-associated mRNAs have, however, revealed both ribosome-dependent (indirect) and ribosome-independent (direct) modes of mRNA association with the ER. These findings raise important questions regarding our understanding of how mRNAs are selected, localized, and anchored to the ER.
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