Publications by authors named "Will Hacker"
Article Synopsis
- Existing anticancer approaches targeting integrins in tumor cells have seen limited effectiveness, prompting the exploration of methods to enhance integrin pathways that inhibit tumor growth.
- A study created a model of metastatic prostate cancer where reducing the α3β1 integrin highlighted its role in signaling through Abl kinases, which limits harmful cell behaviors like migration and invasion.
- The findings suggest that α3 integrin-deficient prostate cancers might benefit from new therapies focusing on the Hippo pathway, revealing complex tumor-suppressing roles for Abl kinases in prostate cancer that could clarify why certain treatments have not worked in clinical trials.
