Publications by authors named "Wilk J"

Article Synopsis
  • * A new clinical trial simulator (CTS) has been developed using five models that track changes in functional test performances, offering a way to optimize trial parameters and endpoints for DMD studies.
  • * This report illustrates the CTS’s functionality through two case studies, showcasing how it can enhance trial design while maintaining statistical significance, ultimately preventing unnecessary increases in trial size and duration.
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  • Heart failure (HF) is a serious condition where the heart fails to pump enough blood, leading to poor organ function and fluid accumulation.
  • Recent research highlights the role of microRNAs (miRNAs) in regulating gene expression related to HF, implicating specific miRNAs like miR-30d and miR-126-3p in heart function and remodeling.
  • Understanding both traditional biomarkers (like natriuretic peptides and troponins) and newer diagnostic methods can enhance the management of HF and its impact on other organs like the kidneys and liver.
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The common iliac arteries (CIA) are the main finals branches of the abdominal aorta. The aim of the present meta-analysis was to demonstrate the most up-to-date and evidence-based data regarding the general anatomy of the CIAs, including their length, take-off angles, and diameters. PubMed, Scopus, Embase, Web of Science, Cochrane Library, and Google Scholar were searched to find all studies considering the anatomy of the CIA.

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A unique case of sterically constrained crystallization arises in bottlebrush polymers bearing semicrystalline side chains. Bottlebrushes with grafted side chains can form crystalline structures governed by the complex interplay between side chain packing and backbone confinement. The confinement effect can be readily tuned by varying the side chain grafting density, thus affording control over the crystallization behavior of these systems.

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Introduction: Future multidomain operational combat environments will require combat medics to play a larger role in managing behavioral health (BH) conditions in forward environments, as soldiers in small teams may have them as their sole medical support for extended periods of time. Previously they were not expected to serve in this role, and thus, they receive minimal BH training. It is unknown to what extent combat medics consider BH tasks as falling within their scope of practice and how often they engage with their soldiers currently related to BH.

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: The thoracic duct (TD) and the cisterna chyli (CC) exhibit a high degree of variability in their topographical and morphometric properties. : PubMed, Scopus, Embase, Web of Science, Cochrane Library, and Google Scholar were searched to identify all studies that included information regarding the morphometric and topographical characteristics of the TD and CC. : The most frequent location of the TD termination was the left venous angle, with a pooled prevalence of 45.

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The controlled dynamization of fractures can promote natural fracture healing by callus formation, while overly rigid fixation can suppress healing. The advent of locked plating technology enabled new strategies for the controlled dynamization of fractures, such as far cortical locking (FCL) screws or active plates with elastically suspended screw holes. However, these strategies did not allow for the use of non-locking screws, which are typically used to reduce bone fragments to the plate.

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Purpose: In the present study, we want to systematize the previous studies on the scapular foramina (SF) and nutrient foramina (NF) with emphasis on the clinical relevance of this topic. Although seemingly not important, radiologists, clinicians and surgeons should be aware of the presence and characteristics of the SF and NF and look out for possible mistakes that may cause harm to the patients during either the diagnostic process or surgery.

Methods: A comprehensive search was conducted in multiple databases, including PubMed, Scopus, Web of Science, Embase, Cochrane Library and Google Scholar.

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Background: The internal iliac artery (IIA) originates from the common iliac artery at the level of the sacroiliac joint and bifurcates between the L5 and S1 vertebrae. The aim of the present meta-analysis was to demonstrate the most up-to-date and evidence-based data regarding the general anatomy of the IIA, including their variations, length, and diameter.

Materials And Methods: Major online medical databases such as PubMed, Scopus, Embase, Web of Science, Cochrane Library, and Google Scholar were searched to find all studies considering the anatomy of the IIA.

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Drug resistance in microorganisms is a serious threat to life and health due to the limited number of antibiotics that show efficacy in treating infections and the difficulty in discovering new compounds with antibacterial activity. To address this issue, the World Health Organization created the AWaRe classification, a tool to support global and national antimicrobial stewardship programs. The AWaRe list categorizes antimicrobials into three groups - Access, Watch, and Reserve - according to their intended use.

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Beekeeping is an extremely difficult field of agriculture. It requires efficient management of the bee nest so that the bee colony can develop efficiently and produce as much honey and other bee products as possible. The beekeeper, therefore, must constantly monitor the contents of the bee comb.

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Sulfonamides circulating in the environment lead to disturbances in food chains and local ecosystems, but most importantly contribute to development of resistance genes, which generate problems with multidrug-resistant bacterial infections treatment. In urban areas, sources of sulfonamide distribution in soils have received comparatively less attention in contrast to rural regions, where animal-derived manure, used as a natural fertilizer, is considered the main source. The aim of this study was to determine eight sulfonamides (sulfadiazine, sulfamerazine, sulfamethazine, sulfamethizole, sulfamethoxazole, sulfapyridine, sulfathiazole, and sulfisoxazole) in environmental soil samples collected from urbanized regions in Silesian Voivodeship with increased animal activity.

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Over the past 20 years, U.S. military conflicts in Iraq and Afghanistan have been marked by high rates of combat and wartime killings.

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Article Synopsis
  • The study investigates how modifying the chemical structure of acene molecules can enhance their electrical properties in organic thin films.
  • It focuses on five specific 10-RO-acenes, which show varying electronic characteristics, and analyzes their hole mobility using experimental methods like SCLC and TOF.
  • The results demonstrate a strong alignment between theoretical predictions and experimental data, suggesting that hole transport occurs through a hopping mechanism influenced by reorganization energy in these amorphous layers.
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Background: Military service inherently includes frequent periods of high-stress training, operational tempo, and sustained deployments to austere far-forward environments. These occupational requirements can contribute to acute and chronic sleep disruption, fatigue, and behavioral health challenges related to acute and chronic stress and disruption of team dynamics. To date, there is no centralized mobile health platform that supports self- and supervised detection, monitoring, and management of sleep and behavioral health issues in garrison and during and after deployments.

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Rationale: Burnout is a personal and occupational phenomenon that has been associated with negative physical and psychological outcomes in medical staff. Additionally, there are implications for healthcare organizations, as those staff who are burned out are more likely to have lower productivity or leave the organization. As with the Covid-19 pandemic, future national emergencies and potentially large-scale conflicts will require similar and likely even larger scale responses from the U.

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Introduction: Multi-domain operational combat environments will likely restrict key components of current behavioral health (BH) service delivery models. Combat teams in far-forward outposts or extended missions may need to rely on their own internal assets to manage combat and operational stress reactions for extended periods of time. As such, combat medics are expected to take on additional responsibilities as providers of BH support for isolated teams.

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Objectives: Excessive alcohol use can bring about adverse health and work-related consequences in civilian and military populations. Screening for excessive drinking can help identify individuals at risk for alcohol-related problems who may require clinical interventions. The brief validated measures of alcohol use such as the Alcohol Use Disorders Identification Test (AUDIT), or abbreviated AUDIT-Consumption (AUDIT-C), are often included in military deployment screening and epidemiologic surveys, but appropriate cut-points must be used to effectively identify individuals at risk.

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Article Synopsis
  • Polymer single crystals serve as templates to create polymer brushes through the PSCAGT method, offering precision in grafting densities and locations.
  • Unlike previous methods that relied on solution crystallization and large solvents, this study uses thin film crystallization to form 2D polymer crystals on flat surfaces.
  • The research reveals that the brushing density can be manipulated by adjusting the chain end distribution via annealing in different nonsolvent media, enhancing the capabilities of the PSCAGT method.
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Lingual nerve (LN) injury during surgical procedures in the third molar region warrants a detailed study of its common pathway and important variations. Therefore, the objective of this study was to analyze and compile the multiple anatomical variations of the LN for use in oral and maxillofacial surgery. It is anticipated that the results of the present meta-analysis may help to minimize the possible complications when performing procedures associated with this anatomical entity.

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The COVID-19 pandemic created the need for telerehabilitation development, while Industry 4.0 brought the key technology. As motor therapy often requires the physical support of a patient's motion, combining robot-aided workouts with remote control is a promising solution.

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Article Synopsis
  • The meta-analysis aimed to provide a comprehensive overview of pituitary gland (PG) morphology by reviewing existing literature and synthesizing data.
  • The average volume of the PG was found to be around 597.23 mm, with noted average differences based on gender and geographic region, indicating Asian females generally have larger PGs than European males.
  • The study's findings also highlight that PG size tends to decrease with age, providing valuable reference points for medical professionals in diagnosing related health issues and guiding surgical procedures.
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The paper presents the results of experimental investigations of mass transfer processes with the use of the limiting current technique. This experimental work analyzed the not fully developed entrance laminar region. The tested case refers to the convective fluid flow through a system of nine long, square mini-channels that are 2 mm wide and 100 mm long.

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