Inflammatory response to chlorhexidine, minocycline HCl and doxycycline HCl in an in vivo mouse model.

Aim: To examine the effect of locally delivered antimicrobial drugs on the inflammatory response in an in vivo mouse chamber model.

Material And Methods: Two weeks following chamber implantation, 24 BALB/c mice, in the experimental group, were given an intra-chamber challenge of heat-killed Porphyromonas gingivalis, followed immediately by injection of the specific antimicrobial drug: 2000 microg/ml chlorhexidine (CHX); 1500 microg/ml minocycline HCl;and 1500 microg/ml doxycycline HCl (concentrations achieved in the periodontal pocket with commercial controlled-release delivery systems). A second group of 24 animals received only the antimicrobial treatment without P.