Can the Gene Variant Have an Effect on the Body Weight of Patients Undergoing Bariatric Surgery?-Preliminary, Exploratory Study.

Background: The gene (Se gene) encoding the enzyme α-1,2-L-fucosyltransferase 2 seems to have a significant effect on the number and type of bacteria colonizing the intestines.

Methods: In a group of 19 patients after bariatric surgery, the polymorphism (rs601338) of gene was analyzed in combination with body mass reduction, intestinal microbiome (16S RNA sequencing), and short chain fatty acids (SCFA) measurements in stools.

Results: Among the secretors (Se/Se polymorphism of the gene rs601338, carriers of GG variant), correlations between waist-hip ratio (WHR) and propionate content and an increase in , , , and were observed.