Investigating the Impact of Co-processed Excipients on the Formulation of Bromhexine Hydrochloride Orally Disintegrating Tablets (ODTs).

Purpose: Orodispersible tablets (orally disintegrating tablets, ODTs) have been used in pharmacotherapy for over 20 years since they overcome the problems with swallowing solid dosage forms. The successful formula manufactured by direct compression shall ensure acceptable mechanical strength and short disintegration time. Our research aimed to develop ODTs containing bromhexine hydrochloride suitable for registration in accordance with EMA requirements.

Inhibiting effect of beta-cyclodextrin on thymine dimerization photosensitized by para-aminobenzoic acid.

Beta-cyclodextrin can act as an efficient inhibitor of the photosensitized dimerization of thymine by para-aminobenzoic acid (PABA) in aqueous solution. This can be explained by considering the formation of an inclusion complex between PABA and beta-cyclodextrin.