Publications by authors named "Wiktor Karpinski"
Article Synopsis
- Evidence suggests that antibodies may help control tuberculosis (TB), but the details of how they work and their potential for therapeutic use are not well explored.
- The researchers created 52 variants of the Fc region of an antibody targeting the Mycobacterium tuberculosis capsule, aiming to enhance its ability to restrict the bacteria.
- Their findings indicate that some engineered antibodies can effectively engage neutrophils to fight the infection by boosting their survival and antimicrobial activity, highlighting the promise of these antibodies as potential TB treatments.
Article Synopsis
- This study investigates how variations in Mycobacterium tuberculosis (M. tuberculosis) may influence tuberculosis infection and treatment results.
- A high-throughput method was used on 158 drug-sensitive strains to analyze their genetic and phenotypic relationships, with a focus on their growth under different host-like conditions.
- Results showed that these strains exhibited diverse growth traits linked to specific genetic mutations, identifying key variants that correlate with clinical outcomes like cavitary disease and treatment failure.
Background: Combatting the tuberculosis (TB) epidemic caused by ( ) necessitates a better understanding of the factors contributing to patient clinical outcomes and transmission. While host and environmental factors have been evaluated, the impact of genetic background and phenotypic diversity is underexplored. Previous work has made associations between genetic lineages and some clinical and epidemiological features, but the bacterial traits underlying these connections are largely unknown.
View Article and Find Full Text PDFRespiratory syncytial virus (RSV) infection is a major cause of respiratory illness in infants and the elderly. Although several vaccines have been developed, none have succeeded in part due to our incomplete understanding of the correlates of immune protection. While both T cells and antibodies play a role, emerging data suggest that antibody-mediated mechanisms alone may be sufficient to provide protection.
View Article and Find Full Text PDFNeutrophils, the most abundant white blood cell, play a critical role in anti-pathogen immunity via phagocytic clearance, secretion of enzymes and immunomodulators, and the release of extracellular traps. Neutrophils non-specifically sense infection through an array of innate immune receptors and inflammatory sensors, but are also able to respond in a pathogen/antigen-specific manner when leveraged by antibodies via Fc-receptors. Among neutrophil functions, antibody-dependent neutrophil phagocytosis (ADNP) results in antibody-mediated opsonization, enabling neutrophils to sense and respond to infection in a pathogen-appropriate manner.
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