Synopsis of recent research by authors named "Wiktor Bohusz"
- Wiktor Bohusz's recent research focuses on the modification and transformation of ansamycin compounds, particularly geldanamycin, to enhance their anticancer properties and selectivity.
- In his July 2023 article, Bohusz describes a metal-free cascade transformation of the geldanamycin benzoquinone core into novel benzoxazole derivatives, highlighting an efficient and environmentally friendly approach to antibiotic functionalization.
- His August 2023 study explores the structural modifications of geldanamycin through CuAAC, resulting in 35 new derivatives with varying affinities to the chaperone protein Hsp90, which suggests potential for improved cytotoxic effects against cancer cells.
