Food Intake and Core Body Temperature of Pups and Adults in a Mouse Line Deficient in the Long Form of the Leptin Receptor without Mutation.

Different involvement of leptin signaling in food intake (FI) and body temperature (BT) in pups and adults has been suggested. However, the leptin receptor (Lepr) long-form-deficient () mouse line has not been fully examined in pups. In the most available mouse line, wild-type (WT) mice have a mutation in the dedicator of cytokinesis 7 gene, named , which was recently revealed to be involved in neuronal development.

Deteriorated glucose metabolism with a high-protein, low-carbohydrate diet in db mice, an animal model of type 2 diabetes, might be caused by insufficient insulin secretion.

Purpose: We previously showed the deleterious effects of increased dietary protein on renal manifestations and glucose metabolism in leptin receptor-deficient (db) mice. Here, we further examined its effects on glucose metabolism, including urinary C-peptide. We also orally administered mixtures corresponding to low- or high-protein diets to diabetic mice.