Juvenile nasopharyngeal angiofibroma with intracranial extension - diagnosis and treatment.

Introduction: This retrospective study analyzes radiological findings, therapeutic management and outcomes of patients with intracranial extension of JNA. The routes of intracranial spread, incidence of intracranial disease and influence on therapeutic approach are discussed.

Material And Methods: An evaluation on the records of 62 patients with JNA was performed and 10 patients with intracranial tumors were included in the study.

Transnasal microscopic approach for juvenile nasopharyngeal angiofibroma.

Introduction: Juvenile nasopharyngeal angiofibroma (JNA) is a rare, benign, vascular tumor originating in the nasopharynx. The treatment of choice for JNA is surgical excision. In recent years, surgical management has been greatly influenced by the use of the transnasal endoscopic technique.

Doppler ultrasound appearance of neck tumors.

Aim: The purpose of this study was the evaluation of the sonographic appearance of neck tumors and determining the features useful in differential diagnosis.

Material And Method: The studied group consisted of 57 patients: 16 patients with carotid body tumors, 9 patients with neurogenic tumors, 8 patients with venous anomalies, 12 patients with neck cysts, 6 patients with lipomas, 5 patients with extracranial carotid artery aneurysms and 1 with a laryngocele.

Results: All carotid paragangliomas were located within the carotid bifurcation and demonstrated rich low-resistance vascular flow, with higher maximum velocity and lower flow resistance parameters registered in the ipsilateral external carotid artery.

Diagnosis and management of multiple paragangliomas of the head and neck.

Paragangliomas (PGs) are slowly growing, usually benign neoplasms. The aim of the study was to analyze the incidence, diagnostic and therapeutic management of patients with multiple paragangliomas of the head and neck. A retrospective review of the records of 84 patients with head and neck PGs, diagnosed and treated in our institution was performed for the years 1983-2013 to identify patients with multiple tumors.

Gelatinolytic activity of matrix metalloproteinases 2 and 9 in middle ear cholesteatoma.

Background: Cholesteatoma of the middle ear or mastoid is a hyperproliferative disorder of keratinocytes characterized by a progressive bone erosion. Matrix metalloproteinase (MMP)-2 and MMP-9 gelatinases are endopeptidases targeting extracellular protein. Several studies examined the role of gelatinases in the pathogenesis of cholesteatoma, but the biologic mechanism by which cholesteatoma destroys the bone tissue remains unclear.

[Cigarette smoking and alcohol consumption in patients with oral cancer].

The study aim was to analyse the frequency of simultaneous smoking and alcohol consumption in 142 patients with oral cancer and in the control group. A connection between the prevalence of these habits and epidemiological traits of the patients and features of malignant lesions was evaluated. Statistical analysis revealed that simultaneous smoking and alcohol abuse were significantly more frequent in the cases group.

[Transpalatal approach for juvenile angiofibroma].

Introduction: Juvenile nasopharyngeal angiofibromas (JNA) are highly vascular, locally invasive tumours which originate in the sphenopalatine foramen. Several surgical approaches are described for this tumour. The aim of this study was to evaluate the transpalatal approach for juvenile angiofibroma.

Laryngeal cancer in farmers from Lublin region of Poland.

The aim of the study was to analyse if work related risk factor had any influence on stage, localisation and histology of type of malignant tumour. Demographic and risk factors and results of treatment of farmers with patients working outside farming were compared. The group included 148 patients with primary laryngeal squamous cell carcinoma (LSCC) diagnosed and treated in our institution in the years 1999-2002.

[Invasion of the orbit in paranasal sinus tumours].

The extension of paranasal sinus cancer into the orbit is one of arguments for carrying out orbital exenteration. Until the advent of high-resolution computed tomography, en bloc radical resection, including the orbit, was the most effective method of treating a cancer, whose size could not be adequately judged before surgery. Patient evaluation with computed tomography (CT) and magnetic resonance imaging (MR) is described.

[Diagnostic evaluation of temporal paragangliomas].

Paragangliomas are rare tumours deriving from paraganglia--small bodies of neuroendocrine tissue. Approximately 3% of paragangliomas occur in the head and neck area accounting for about 0,6% of all tumours of this region. Head and neck paragangliomas are divided into two groups: neck tumours (carotid body tumor and vagal paraganglioma) and temporal paragangliomas (jugular bulb tumor and tympanic paraganglioma).

[Extension of nasal and paranasal sinus malignancies on the basis of computed tomography].

Introduction: Location and extension of tumour are crucial for results of treatment and prognosis in patients with nasal and paranasal sinus malignancies. The aim of the study was to evaluate the site and extension of nasal and paranasal sinus malignancies using computed tomography (CT).

Material And Method: The group included 124 patients aged 5-83 years.

An immunohistochemical study of cyclin D1 protein expression in laryngeal squamous cell carcinoma.

Conclusion: Contrary to most reports, our study shows that the expression of cyclin D1 is not an independent prognostic factor in patients with laryngeal cancer (LC). No correlation between cyclin D1 expression and survival rates in LC was found in a multivariate analysis.

Objectives: The aim of this study was to determine the possible relevance of the expression of cyclin D1 protein in LC as prognostic criteria and to analyse correlation of the expression with clinicopathological features and survival rates.

The influence of the sequence of surgical steps on complications rate in stapedotomy.

Objective: To assess whether the incidence of complications of stapes surgery depended on the sequence of surgical steps and CO2 laser use in stapes surgery.

Study Design And Setting: Retrospective and prospective analysis of 420 consecutive stapedotomies was set in tertiary referral University Hospital.

Patients: 376 patients with otosclerosis in whom 420 primary stapedotomies were performed.

Comprehensive genomic analysis identifies MDM2 and AURKA as novel amplified genes in juvenile angiofibromas.

Background: Frequent beta-catenin mutations have been detected in juvenile angiofibromas, but the tumor pathogenesis remains unknown.

Methods: Metaphase-comparative genomic hybridization (CGH) was used to identify chromosomal aberrations in 29 tumor specimens. Two tumors were investigated using genome DNA microarrays.

A rare case of nasopharyngeal angiofibroma in an elderly female.

Nasopharyngeal angiofibromas occur predominantly in males in their puberty and adolescence; the incidence in other age groups and in women is exceptional. This report describes a case of a 57-year-old woman with nasopharyngeal angiofibroma presenting typical radiological findings in computed tomography, MR imaging and angiography. The tumour was successfully removed and histopathological examination confirmed the diagnosis.

[Site of origin of paranasal sinus malignancies].

In a group of 124 patients a site of origin of paranasal sinus and nasal cavity malignancies was evaluated on the basis of computed tomography (CT) and on the basis of operative findings. The most common malignant tumor was squamous cell carcinoma (41, 1%) and then cancers of salivary origin (20, 2%). The most common site of origin was the maxillary sinus (53, 2%) and then the nasal cavity (31, 5%).

[Reconstruction of meatal wall with cartilage and perichondrium].

The aim of the study was evaluation of the use of cartilage and perichondrium for reconstruction of meatal wall. In the group of 27 patients transmeatal atticotomy was performed to remove cholesteatoma from epitympanic recess. Auricular or tragal perichondrium with cartilage island were used for reconstruction of meatal wall and tympanic membrane defect.

[The prevalence of E6/E7 HPV type 16 in laryngeal cancer and in normal mucosa].

Many authors suggest that HPV infection can play a great role in development of benign and malignant tumours of upper respiratory tract in human. The aim of this study was to determine the prevalence of E6/E7 HPV-16 in laryngeal squamous cell carcinoma, and normal laryngeal mucosa, and to analyse their correlation with sex, lymph node status, primary tumor stage, localization, and histological differentiation. HPV 16 DNA presence was analysed using PCR technique in 72 samples of laryngeal carcinoma and in samples of 50 normal mucosa.

[The use of tracheostomy T-tube in the treatment of tracheal stenosis].

The aim of the study was evaluation of the use of tracheostomy T-tube in patients with tracheal stenosis. The advantages of closed T-tube over open tracheotomy are: 1/ normal breathing through the nose, 2/ normal speech without necessity to close the tube with a finger, 3/ no spitting during cough. Silicone tracheostomy T-tube was used in 12 patients with tracheal stenosis.

[Speech rehabilitation using Provox voice prosthesis].

The first voice prosthesis was described in 1972 by Mozolewski. Eight years later Blom and Singer constructed the first commercial prosthesis. In 1988 another prosthesis was presented as Provox system prosthesis.

Immunohistochemical demonstration of multiple HPV types in laryngeal squamous cell carcinoma.

The aim of this study was to determine the prevalence of human papillomaviruses (HPV) types 6, 11, 16, 18, 31, 33, 42, 51, 52, 56 and 58 in laryngeal squamous cell carcinoma specimens using immunohistochemical reactions and to correlate the presence of HPV with the clinical and pathological characteristics of these patients. Tissue samples were collected from 40 patients with primary laryngeal squamous cell carcinoma (LSCC) and from 33 subjects with non-neoplastic laryngeal lesions or laryngeal nodules, which served as a control group. Human papilloma virus was detected in 6 (15%) of the 40 patients.

[Juvenile angiofibroma: the value of CT and MRI for treatment planning and follow-up].

Juvenile angiofibroma is a rare, benign, hypervascular, nasopharyngeal tumour. The aim of the study was to assess the value of CT and MR in determining therapeutic approach and follow-up in patients with this condition. There were 40 patients with juvenile angiofibroma.

[Cat-scratch disease of the parotid gland].

Cat-scratch disease is a mild disease associated with regional lymph node enlargement. We present a case of cat-scratch disease of the parotid gland in 10-year-old girl. She presented with painful parotid mass, after unsuccessful treatment with antibiotics.

Epstein-Barr virus antibodies in patients with laryngeal and hypopharyngeal cancer.

Epstein-Barr virus (EBV) is a member of the herpesvirus family. The EBV genome consists of a linear DNA molecular that encoded nearly 100 viral proteins. EBV is one of the most successful viruses, infecting over 95 percent of the adult population of the world.

Solid tumours of perimeningeal region in children--diagnostic and therapeutic difficulties.

Thirteen patients, aged 2-17 years, were treated because of primary solid tumours of head and neck location at the Department of Children Hematology and Oncology in Lublin. The authors analyzed clinical symptoms before diagnosis and the duration of these symptoms as well as the kind of tumours. In all cases the tumour was diagnosed on histopathological examination: soft tissue sarcomas--9 children, lymphoepithelioma--4 ones.