Integrating remote sensing and UAV imagery for detection of invasive Hovenia dulcis Thumb. (Rhamnaceae) in urban Atlantic Forest remnants.

The invasive species Hovenia dulcis is considered the main invasive species in the Atlantic Forest, capable of altering environmental conditions at a local scale and provoking profound changes in the composition of the plant community. Combining drone and satellite images can make forest monitoring more efficient, enabling a more targeted and effective response to contain the spread of invasive species. This research aimed to use high-resolution CBERS-4A satellite combined with drone images to detect invasive trees in forested areas of the Atlantic Forest.

Sex-Related Outcomes in Asymptomatic Patients Undergoing Carotid Artery Stenting.

Purpose: Aim of the study was to evaluate the influence of sex in asymptomatic patients undergoing carotid artery stenting (CAS).

Materials And Methods: A retrospective observational study was conducted from January 2006 to December 2020. A total of 438 consecutive patients with asymptomatic carotid artery stenosis >70% underwent transfemoral CAS and were stratified in males (M) and females (F).

Setanaxib, a first-in-class selective NADPH oxidase 1/4 inhibitor for primary biliary cholangitis: A randomized, placebo-controlled, phase 2 trial.

Background: Primary biliary cholangitis (PBC) is a rare liver disease with significant unmet need for second-line/add-on treatments. Setanaxib, a NOX1/4 inhibitor, has shown anti-fibrotic effects in in vitro and animal studies. This phase 2, randomized, multicentre study investigated the efficacy and safety of setanaxib in patients with PBC.

[Frequent Gastro-Intestinal Disorders: Management of Functional Dyspepsia and Irritable Bowel Syndrome in Clinical Practice].

Frequent Gastro-Intestinal Disorders: Management of Functional Dyspepsia and Irritable Bowel Syndrome in Clinical Practice Functional dyspepsia (FD) and irritable bowel syndrome (IBS), two common gastrointestinal entities with overlapping symptoms, should be diagnosed according to Rome IV criteria. This includes one or more of the following symptoms: in FD, postprandial fullness, early satiation, epigastric pain or burning; in IBS, recurrent abdominal pain associated with defecation, change in frequency of stool or form of stool. To exclude structural diseases, attention should be paid to alarm symptoms.

Impact of setanaxib on quality of life outcomes in primary biliary cholangitis in a phase 2 randomized controlled trial.

Background: There is a real unmet need for primary biliary cholangitis (PBC) treatments that can improve quality of life impacting symptoms. In this post hoc analysis, we evaluated potential effects of the NADP oxidase 1/4 inhibitor, setanaxib, on patient-reported quality of life from a phase 2 trial in PBC.

Patients And Methods: The underpinning double-blind, randomized, placebo-controlled trial (NCT03226067) recruited 111 patients with PBC and inadequate response/intolerance to ursodeoxycholic acid.

Total Endovascular Aortic Replacement in Post-Dissecting Thoraco-Abdominal Aortic Aneurysm with A New Inner Branched Device.

To describe a new inner-branched device used to treat two cases of chronic post-dissection aortic thoraco-abdominal aneurysms (PD-TAAAs) after ascending aortic surgery. A 67-year-old male who had undergone an ascending aorta and arch surgical replacement and a 70-year-old male with a previous Bentall procedure for acute type A aortic dissection were admitted at our department with a PD-TAAA diagnosis. Both patients were defined unfit for open surgery by a multidisciplinary team and a totally percutaneous endovascular repair was planned.

Preliminary results from a multicenter Italian registry on the use of a new branched device for the treatment of thoracoabdominal aortic aneurysms.

Objective: The study purpose was to present early outcomes of patients treated for thoracoabdominal aortic aneurysms or complex abdominal aortic diseases using endovascular repair with a new branched endograft.

Methods: This multicenter, retrospective, observational cohort study included all patients treated with a new branched endograft. All elective patients were treated with a staged operative strategy and spinal drainage Primary outcomes of interest were technical success, early (≤30 days) mortality, and late (≥30 days) survival, and freedom from adverse aortic events.

Acute Distress Respiratory Syndrome and Cardiac Shock after AngioJet Thrombectomy for Acute Occlusion of an Aortic Endograft.

Partial thrombosis or total occlusion of aortic or limb graft are possible complications after endovascular aneurysm repair. Different strategies for therapeutic management are available; these include open surgical techniques or endovascular treatments. The choice of the treatment depends on the patient's clinical conditions and on the timing of the thrombosis.

Endovascular Treatment of Multiple Ruptures of Postdissecting Thoraco Abdominal Aortic Aneurysm with a Custom Branched Device Used as an Off-the-shelf Device.

Endovascular treatment of postdissection aortic aneurysms (PDAAs) is fascinating and challenging. The Colt branched graft (Jotec/Cryolife, Kennesaw, Georgia), because of its characteristics, can be used as an off-the-shelf device especially in urgent/emergency settings. In this report, we describe the first case of a PDAA successfully treated with a Colt device.

NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors.

Determining mechanisms of resistance to αPD-1/PD-L1 immune-checkpoint immunotherapy is key to developing new treatment strategies. Cancer-associated fibroblasts (CAF) have many tumor-promoting functions and promote immune evasion through multiple mechanisms, but as yet, no CAF-specific inhibitors are clinically available. Here we generated CAF-rich murine tumor models (TC1, MC38, and 4T1) to investigate how CAFs influence the immune microenvironment and affect response to different immunotherapy modalities [anticancer vaccination, TC1 (HPV E7 DNA vaccine), αPD-1, and MC38] and found that CAFs broadly suppressed response by specifically excluding CD8 T cells from tumors (not CD4 T cells or macrophages); CD8 T-cell exclusion was similarly present in CAF-rich human tumors.

Floating treatment wetlands: A review and bibliometric analysis.

Floating treatment wetlands (FTWs) have attained tremendous popularity for water purification purposes. Through this phyto-technology, naturally occurring macrophytes are allowed to grow on the water surface on a buoyant raft or a rigid support, keeping the plant roots permanently in contact with the water and removing pollutants via several processes. The objective of this study was to review studies that have developed FTWs and to perform a bibliometric analysis using three keywords: "Floating", "Treatment" and "Wetlands".

Endovascular and Hybrid Management of Patients Affected by Abdominal Aortic Aneurysm and Occlusion of the Iliac Arteries.

Unlabelled: The presence of a concomitant aortoiliac occlusive disease and abdominal aortic aneurysm (AAA) is rare and limits the implant of a bifurcated endograft.

Background: The objective of the study was to evaluate early and midterm results of an endovascular or a hybrid approach in patients undergoing iliac revascularization and AAA exclusion.

Methods: We reviewed our clinical series of patients from January 2016 to February 2018.

[Functional gastrointestinal disorders: update on the Rome IV criteria].

Functional gastrointestinal disorders are highly prevalent worldwide and may have an important impact on the quality of life of affected patients. In addition, they are associated with a major socio-economic impact. In 2016 the Rome IV criteria were published that provided an update of the 2006 published Rome III criteria for functional gastrointestinal disorders.

Therapeutic potential of NADPH oxidase 1/4 inhibitors.

Unlabelled: The NADPH oxidase (NOX) family of enzymes produces ROS as their sole function and is becoming recognized as key modulators of signal transduction pathways with a physiological role under acute stress and a pathological role after excessive activation under chronic stress. The seven isoforms differ in their regulation, tissue and subcellular localization and ROS products. The most studied are NOX1, 2 and 4.

Endovascular treatment of multiple aneurysms complicating Cogan syndrome.

To report the use of endografts to manage multiple aneurysms due to Cogan syndrome (CS). A 38-year-old woman with descending thoracic aorta and right common carotid artery aneurysms due to CS was treated with endovascular grafts. After 4 years, angio computed tomography scan demonstrated complete exclusion of the aneurysms with no signs of endoleak, whereas echo color Doppler showed patency of the carotid graft, no signs of restenosis, no progression of the disease in the landing zones, and complete aneurysm exclusion.

Endovascular management of type Ib endoleak complicating a juxtarenal aortic aneurysm previously treated with a multilayer stent.

Background: To report the use of an endograft to manage a type Ib endoleak in a patient with a juxtarenal aortic aneurysm previously treated with a multilayer stent.

Methods: Under compassionate use, a 68-year-old patient with a juxtarenal aortic aneurysm and multiple comorbidities was treated with a multilayer flow modulating stent. Twelve months later a new computed tomography (CT) scan identified a type Ib endoleak with an increase in the aortic aneurysm size because of the extension of the aneurysmal disease to the aortic carrefour.

Direct electrical stimulation using a battery-operated device for induction and modulation of colonic contractions in pigs.

Direct electrical stimulation of the colon offers a promising approach for the induction of propulsive colonic contractions by using an implantable device. The objective of this study was to assess the feasibility to induce colonic contractions using a commercially available battery-operated stimulator (maximum pulse width of 1 ms and maximum amplitude of 10 V). Three pairs of pacing electrodes were inserted into the cecal seromuscular layer of anesthetized pigs.

[Investigations for esophageal motility and reflux].

High resolution manometry represents an interesting technological advance, facilitating the procedure, a continuous recording of the peristalsis on a single image, a user-friendly reading of the spatio-temporal relationship of the peristaltic waves, and the identification of suspended focal abnormalities. Telemetric pH-metry, performed by insertion of a wireless capsule directly in the oesophagus, now remplaces conventional pH-metry, which requires a naso-oesophageal line. The main acquisition in 2008 is, however, the advent of oesophageal pH-impedancemetry.

Electrical stimulation induces propagated colonic contractions in an experimental model.

Background: Direct colonic electrical stimulation may prove to be a treatment option for specific motility disorders such as chronic constipation. The aim of this study was to provoke colonic contractions using electrical stimulation delivered from a battery-operated device.

Methods: Electrodes were inserted into the caecal seromuscular layer of eight anaesthetized pigs.

Spliceosomal peptide P140 for immunotherapy of systemic lupus erythematosus: results of an early phase II clinical trial.

Objective: To assess the safety, tolerability, and efficacy of spliceosomal peptide P140 (IPP-201101; sequence 131-151 of the U1-70K protein phosphorylated at Ser140), which is recognized by lupus CD4+ T cells, in the treatment of patients with systemic lupus erythematosus (SLE).

Methods: An open-label, dose-escalation phase II study was conducted in two centers in Bulgaria. Twenty patients (2 male and 18 female) with moderately active SLE received 3 subcutaneous (SC) administrations of a clinical batch of P140 peptide at 2-week intervals.