Publications by authors named "Wiebke Tessmer"
Article Synopsis
- - This study explored how the immune response to psychological stress from a cognitive task differs between multiple sclerosis (MS) patients and healthy individuals, focusing on cytokine production and heart rate variations.
- - Results showed that while MS patients reported higher fatigue levels than controls, their baseline immune responses were similar, but they had a blunted IFNgamma response after stress, and their heart rate increased less during the task.
- - Additionally, cognitive impairment in MS patients was linked to decreased heart rate reactivity, indicating possible autonomic dysfunction, while depressive symptoms were associated with stronger IL-10 responses.
We designed this longitudinal study to clarify the short- and long-term effects of mitoxantrone on the immune system in a subgroup of multiple sclerosis patients treated at our centre. After 14 days we found a highly significant sustained reduction of leucocytes, primarily affecting neutrophils and most lymphocyte subsets except for naive and activated T lymphocytes. The CD4/CD8 ratio and serum immmunoglobulin levels were not affected.
View Article and Find Full Text PDFMultiple sclerosis (MS) is an autoimmune disease affecting the central nervous system. An impaired hypothalamopituitary axis and stress reactivity have extensively been discussed without convincing experimental evidence. We choose a standardized acute psychological stressor to determine whether MS patients show altered endocrine and immune responses to stress.
View Article and Find Full Text PDF