Publications by authors named "Wiebke Chemnitz"
Background: Macrophages play important roles in phagocytosing tumor cells. However, tumors escape macrophage phagocytosis in part through the expression of anti-phagocytic signals, most commonly CD47. In Ewing sarcoma (ES), we found that tumor cells utilize dual mechanisms to evade macrophage clearance by simultaneously over-expressing CD47 and down-regulating cell surface calreticulin (csCRT), the pro-phagocytic signal.
View Article and Find Full Text PDFA novel DNA nuclease is stimulated by association with the GINS complex.
Nucleic Acids Res
August 2011
Article Synopsis
- A previously uncharacterized protein, TK1252p, in the archaeon Thermococcus kodakaraensis, interacts with the GINS complex, which is crucial for DNA replication.
- TK1252p acts as a single-strand DNA-specific exonuclease that degrades DNA in the 5' → 3' direction and enhances enzyme activity when bound to the GINS15 subunit.
- This newly identified enzyme, named GINS-associated nuclease (GAN), plays important roles in the assembly of the replisome and in the DNA replication process.