Publications by authors named "Wido Budde"
Diurnal Intraocular Pressure Profiles in Chronic Open-Angle Glaucoma.
Asia Pac J Ophthalmol (Phila)
June 2015
Purpose: To evaluate day-and-night intraocular pressure (IOP) profiles in normal and glaucomatous eyes.
Design: Hospital-based clinical observational study.
Methods: The study included 3561 day-and-night profiles of IOP measurements performed by Goldmann applanation tonometry on 1408 eyes of 720 normal Caucasian subjects or chronic open-angle glaucoma patients.
Purpose: To evaluate circadian intraocular pressure (IOP) profiles in eyes with different types of chronic open-angle glaucoma (COAG) and normal eyes.
Methods: This study included 3,561 circadian IOP profiles obtained from 1,408 eyes of 720 Caucasian individuals including glaucoma patients under topical treatment (1,072 eyes) and normal subjects (336 eyes). IOP profiles were obtained by Goldmann applanation tonometry and included measurements at 7 am, noon, 5 pm, 9 pm, and midnight.
Purpose: Numerous genetic diseases and environmental stimuli affect optic nerve morphology. The purpose of this study was to identify the principal heritable components of visible optic nerve head structures in a population-based sample of twins.
Methods: Fifteen optic nerve specialists viewed stereoscopic optic nerve head photographs (Stereo Viewer-II; Pentax Corp.
Purpose: To evaluate whether iris colour influences size and shape of the optic nerve head and risk for glaucoma progression.
Methods: The hospital-based observational study included 1973 eyes of 1012 Caucasian subjects with ocular hypertension or chronic open-angle glaucoma. For all patients, colour stereo optic disc photographs were evaluated, and corneal pachymetry and achromatic perimetry were performed.
Purpose: The aim of this study is to report on the clinical course of a patient showing markedly increased intraocular pressure (IOP) caused by intravitreal triamcinolone acetonide.
Methods: A 33-year-old patient received an intravitreal injection of approximately 20 mg of triamcinolone acetonide (TA) as treatment of otherwise therapy-resistant uveitis. She experienced an IOP rise to values over 40 mmHg for a period for more than 3 months, despite maximal antiglaucomatous medical therapy.
Effect of uncomplicated phacoemulsification on the central retina in diabetic and non-diabetic subjects.
Graefes Arch Clin Exp Ophthalmol
January 2007
Background: The purpose of this study was to evaluate the subclinical influence of uncomplicated cataract surgery on foveal thickness and volume in the early postoperative period.
Methods: In a prospective study, 108 eyes were assessed by optical coherence tomography preoperatively and 1 day, 1 week and 4 weeks after uncomplicated small incisional phacoemulsification with endocapsular intraocular lens (IOL) implantation under topical anesthesia. The study included 24 eyes of diabetic patients.
Purpose: Optical coherence tomography may be a new technique for quantitative 3-dimensional assessment of the optic nerve head for diagnosis of optic nerve anomalies and diseases such as the glaucomas. The purpose of the present study was to examine its reproducibility.
Patients And Methods: The clinical noninterventional study included 10 randomly chosen eyes of 10 healthy individuals who underwent 24 optical coherence tomographic examinations with the high-resolution and fast scan program, interactively corrected or uncorrected.
Purpose: To evaluate whether keratometric readings as a measure of corneal shape are associated with optic disc dimensions and with the degree and rate of perimetric progression of chronic open-angle glaucoma or ocular hypertension.
Methods: The hospital-based observational study included 1826 eyes of 936 patients with ocular hypertension, patients with chronic open-angle glaucoma, or normal individuals. For 733 ocular hypertensive or glaucomatous eyes, follow-up examinations were performed with a mean follow-up time of 58.
Purpose: Optical coherence tomography (OCT) is an established method for visualising macular pathology and for measuring the thickness of parapapillary retinal nerve fibre layer. The purpose of the present study was to compare OCT measurements of the optic disc with those obtained by planimetry of fundus photographs and to investigate whether OCT measurements are influenced by the amount of parapapillary atrophy or pigmentary conus at the disc margin.
Materials And Methods: Eighty-two eyes of 41 randomly selected Asian-Indian subjects were included.
Purpose: To evaluate the probability of a single intraocular pressure measurement to be the highest measurement within a diurnal intraocular pressure profile.
Design: Hospital-based clinical, observational study.
Methods: The study included 3,025 day-and-night intraocular pressure profiles measured on 1,072 eyes of 547 Caucasian glaucoma patients or glaucoma suspects.
Purpose: To evaluate whether various types of chronic open-angle glaucoma differ in predictive factors for progression of glaucomatous optic nerve damage.
Design: Observational cohort study.
Setting: Prospective observational clinical study.
Central corneal thickness correlated with glaucoma damage and rate of progression.
Invest Ophthalmol Vis Sci
April 2005
Purpose: To evaluate whether the amount of glaucomatous optic nerve damage at presentation of the patient and the rate of progression of glaucoma during follow-up are related to central corneal thickness.
Methods: The prospective observational clinical study included 861 eyes of 454 white subjects (239 normal eyes of 121 subjects, 250 ocular hypertensive eyes of 118 patients, 372 eyes of 215 patients with chronic open-angle glaucoma). For 567 eyes (304 patients) with ocular hypertension or chronic open-angle glaucoma, follow-up examinations were performed, with a mean follow-up time of 62.
Purpose: To compare optical coherence tomography (OCT) and confocal scanning laser tomography (cSLT) for quantitative retinal thickness mapping of the macula and their ability to detect macular edema.
Design: Prospective, comparative, clinical observational study.
Methods: The study population of 138 eyes (97 patients) was divided into a study group consisting of 45 (32.
Purpose: To evaluate which morphologic features of the optic disc are predictive factors for the development or progression of visual field loss in chronic open-angle glaucoma.
Methods: The prospective observational clinical study included 763 eyes of 416 white subjects with ocular hypertension and chronic open-angle glaucoma. During the follow-up time (mean, 67.
Purpose: To evaluate whether an optic disc hemifield test comparing the superior half of the optic disc with the inferior disc half is useful for glaucoma diagnosis.
Methods: The clinical observational study included 1268 patients with primary or secondary open-angle glaucoma and 649 normal subjects. The glaucoma group was divided into 1118 patients with glaucomatous visual field defects ("perimetric glaucoma"), and 150 patients with optic nerve head changes and normal visual fields ("preperimetric glaucoma").
Enlargement of parapapillary atrophy in follow-up of chronic open-angle glaucoma.
Am J Ophthalmol
April 2004
Purpose: To assess the frequency of an enlargement of parapapillary atrophy in follow-up of eyes with open-angle glaucoma.
Methods: Prospective observational longitudinal study.
Setting: Institutional.
Objective: To evaluate the outcome of repeated intravitreal injections of triamcinolone acetonide for the treatment of exudative age-related macular degeneration.
Methods: This prospective, comparative nonrandomized clinical interventional study included 13 patients with progressive exudative age-related macular degeneration with occult, or predominantly occult, subfoveal neovascularization. All patients had shown an increase or stabilization of visual acuity after a first intravitreal injection of 25 mg of triamcinolone acetonide.
Purpose: To evaluate the detectability of glaucomatous optic disc hemorrhages by confocal scanning laser tomography.
Methods: The study included 73 eyes of 63 patients, who consecutively showed optic disc hemorrhages on 15 degrees color optic disc photographs taken at baseline or during follow-up examinations and for whom confocal scanning laser tomographic images were additionally available. Of the total number of 92 observed hemorrhages, 51 hemorrhages extended into the parapapillary region and 41 hemorrhages were restricted to the intrapapillary region.
Purpose: To examine the relationship between morphologic optic disc parameters and hemodynamic parameters as measured by confocal laser scanning Doppler flowmetry in patients with normal-pressure glaucoma.
Methods: The study included 91 eyes of 54 patients with normal-pressure glaucoma (mean age: 57.7 +/- 9.
Background: Large-scale screening in glaucoma diagnosis is expensive and time consuming. Sequential classification strategies can provide an effective combination of time-efficiency and diagnostic accuracy for glaucoma screening.
Methods: In a cross-sectional clinical study, a sequential diagnostic strategy, based on several psychophysical and electrophysiological tests, was evaluated on measurements from 595 eyes from 310 patients with primary open-angle glaucoma, and 419 eyes from 213 control subjects (age range 18-70 years in each group).
Influence of cilioretinal arteries on neuroretinal rim and parapapillary atrophy in glaucoma.
Invest Ophthalmol Vis Sci
January 2003
Purpose: The pattern of neuroretinal rim loss and increase in the area of parapapillary atrophy in glaucoma depend on the localization of the central retinal vessel trunk in the lamina cribrosa. The purpose of the present study was to determine whether, in a similar way, the pattern of rim loss and progression of parapapillary atrophy are influenced by the presence and position of cilioretinal arteries.
Methods: Color stereo optic disc photographs (15 degrees) for morphometric evaluation of the optic nerve head were used to compare the appearance of the optic disc in 41 patients exhibiting unilateral or bilateral cilioretinal arteries in the temporal horizontal disc region with the optic disc morphology of 127 patients without cilioretinal arteries.
Objective: Flame-shaped optic disc hemorrhages are a hallmark of glaucomatous optic neuropathy. The purpose of this study was to evaluate which parameters differ between companion eyes with and without an optic disc hemorrhage in patients with chronic open-angle glaucoma.
Design: Comparative (companion eye) observational case series.
Anisometropia and degree of optic nerve damage in chronic open-angle glaucoma.
Am J Ophthalmol
October 2002
Purpose: To address the question of whether the refractive error plays a role in the amount of optic nerve damage in glaucoma, we intraindividually compared inter-eye differences in refractive error with inter-eye differences in parameters indicating the degree of glaucomatous optic nerve damage, and we interindividually correlated refractive error with neuroretinal rim area and visual field loss.
Design: Comparative clinical observational study.
Methods: This comparative clinical observational study was conducted in a university eye hospital.