Publications by authors named "Widmann G"

Background And Aims: The interaction of serum uric acid (SUA) with atherogenesis is incompletely understood. Aim of our study was to investigate the association of SUA levels with coronary plaque composition including high-risk-plaque (HRP) features by coronary computed tomography angiography (CTA) and for the prediction of major adverse cardiac events (MACE).

Methods And Results: 1242 patients (age 66.

View Article and Find Full Text PDF
Article Synopsis
  • Stroke is a significant risk following transcatheter aortic valve implantation (TAVI), and this study aimed to determine if patterns from CT scans can predict stroke or transient ischemic attacks (TIA) in patients with severe aortic stenosis.
  • The research included 124 patients and found that stroke/TIA occurred in 9.6% of cases; late-phase filling defects (FDs) in the left atrial appendage (LAA) were significantly linked to stroke, while early-phase FDs showed some correlation, particularly with lower density values.
  • The study concluded that ongoing LAA filling defects observed in late-phase CT scans and certain density criteria from early-phase scans may enhance the assessment of stroke risk, suggesting a
View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the impact of SARS-CoV-2 on the cardiovascular system, specifically looking at how the virus affects the endothelium and can lead to coronary artery diseases and vasculitis.
  • Researchers performed coronary computed tomography angiography (CTA) on patients recently infected with SARS-CoV-2 to identify atypical coronary lesions and related inflammation.
  • Results showed that while a significant number of acute patients exhibited serious heart conditions, most stable patients did not have severe coronary artery disease, highlighting the usefulness of CTA in evaluating COVID-19 related cardiac issues.
View Article and Find Full Text PDF

Objective: Lipomatous hypertrophy of the interatrial septum (LHIS) is a distinct section of epicardial adipose tissue. However, its association with COPD is poorly documented.

Methods: Patients undergoing coronary computed tomography angiography (CTA) for clinical indications were recruited retrospectively and screened for LHIS and COPD.

View Article and Find Full Text PDF

Background: Cardiovascular risk (CV)-stratification in females is challenging, and current models miss a high proportion at-risk. Breast arterial calcifications (BAC) are independent prognosticators, but their interaction with the coronary artery disease profile by computed tomography (CT) is controverse, and the role of BAC 0 unclear.

Objective: to investigate the interaction of BAC with coronary CT outcomes (CAC score, coronary stenosis severity and high-risk plaque (HRP).

View Article and Find Full Text PDF

Objective: Novel pericardial adipose tissue imaging biomarkers are currently under investigation for cardiovascular risk stratification. However, a specific compartment of the epicardial adipose tissue (EAT), lipomatous hypertrophy of the interatrial septum (LHIS), is included in the pericardial fat volume (PCFV) quantification software. Our aim was to evaluate LHIS by computed tomography angiography (CTA), to elaborate differences to other pericardial adipose tissue components (EAT) and paracardial adipose tissue (PAT), and to compare CT with [F]FDG-PET.

View Article and Find Full Text PDF

Purpose: To evaluate the diagnostic performance (DP) of the high-resolution contrast computed tomography (HR-contrast-CT) based Neck-Persistency-Net in distinguishing vital from non-vital persistent cervical lymph nodes (pcLNs) in patients with advanced head and neck squamous cell carcinoma (HNSCC) following primary concurrent chemoradiotherapy (CRT) with [18F]-fluorodeoxyglucose positron emission tomography and high-resolution contrast-enhanced computed tomography ([18F]FDG-PET-CT). Furthermore, the Neck-Persistency-Net's potential to justify omitting post-CRT neck dissection (ND) without risking treatment delays or preventing unnecessary surgery was explored.

Methods: All HNSCC patients undergoing primary CRT followed by post-CRT-ND for pcLNs recorded in the institutional HNSCC registry were analyzed.

View Article and Find Full Text PDF

Purpose: Endovascular aneurysm repair has emerged as the standard therapy for abdominal aortic aneurysms. In 9-30% of cases, retrograde filling of the aneurysm sac through patent branch arteries may result in persistence of blood flow outside the graft and within the aneurysm sac. This condition is called an endoleak type II, which may be treated by catheter-based embolization in case of continued sac enlargement.

View Article and Find Full Text PDF

Objectives: Public campaigns such as the "Go-red-for-women"-initiative have raised heart-disease awareness and may trigger overutilization of coronary computed tomography angiography (CTA). Objective was to investigate the diagnostic efficacy of coronary CTA stratified by age and gender.

Methods: 1882 consecutive patients (58.

View Article and Find Full Text PDF

Photon-counting detector computed tomography (PCD-CT) represents a revolutionary new generation of computed tomography (CT) for the imaging of patients with cardiovascular diseases. Since its commercial market introduction in 2021, numerous studies have identified advantages of this new technology in the field of cardiovascular imaging, including improved image quality due to an enhanced contrast-to-noise ratio, superior spatial resolution, reduced artifacts, and a reduced radiation dose. The aim of this narrative review was to discuss the current scientific literature, and to find answers to the question of whether PCD-CT has yet led to a true step-change and significant progress in cardiovascular imaging.

View Article and Find Full Text PDF

Objective: To determine the association of cardiovascular atherosclerotic plaque monosodium urate deposits with the occurrence of major cardiovascular events in gout and hyperuricemia patients.

Methods: This retrospective cohort study included patients with clinically suspicion of gout, who performed a dual energy computed tomography of the affected limb and thorax between June 1st, 2012 and December 5th, 2019. Clinical and laboratory parameters were retrieved from patientś charts.

View Article and Find Full Text PDF

Background: Nasal airway stenosis may lie anterior and/or posterior to the piriform aperture. We intended to compare the nasal airway anterior and posterior to the piriform aperture in patients with and without nasal obstruction.

Methods: Segmented computed tomography cross-sectional areas of the nasal airway anterior (CT-CSA) and posterior to the piriform aperture (at the level of the head of the inferior turbinate; CT-CSA) were compared between patients with nasal obstruction (cases) and trauma controls.

View Article and Find Full Text PDF

Purpose: Overutilization of healthcare resources is causing a high socioeconomic burden. Patients with high coronary artery calcium (CAC) scores > 1000AU are not optimal candidates for coronary CTA and better suited for other diagnostic strategies. Therefore, our objective was to evaluate whether a 4-scale aortic arch calcification severity (AoArCa) score from CT and X-Ray predicts high-CAC scores.

View Article and Find Full Text PDF

Patients with locally advanced head and neck squamous cell carcinoma (HNSCC) frequently require primary radiochemotherapy (RCT). Despite intensity modulation, the desired radiation-induced effects observed in HNSCC may also be observed as side effects in healthy tissue, e.g.

View Article and Find Full Text PDF
Article Synopsis
  • - PBRM1 mutations, affecting around 8.1% of biliary tract cancers (BTCs), are more common in intrahepatic BTCs and are associated with higher rates of additional mutations in chromatin-remodeling and DNA damage repair genes.
  • - Despite the presence of PBRM1 mutations, overall survival rates for patients with these mutations do not significantly differ from those without.
  • - In laboratory tests, the use of PARP and ATR inhibitors showed potential effectiveness against BTCs with PBRM1 loss of function, suggesting a new avenue for treatment in patients with these mutations.
View Article and Find Full Text PDF

Ionizing radiation is necessary for diagnostic imaging and deciding the right radiation dose is extremely critical to obtain a decent quality image. However, increasing the dosage to improve the image quality has risks due to the potential harm from ionizing radiation. Thus, finding the optimal as low as diagnostically acceptable (ALADA) dosage is an open research problem that has yet to be tackled using artificial intelligence (AI) methods.

View Article and Find Full Text PDF

Purpose: Maxillofacial trauma predominantly affects young adults between 20 and 40 years of age. Although radioprotection is a legal requirement, the significant potential of dose reduction in computed tomography (CT) is still underused in the clinical routine. The objective of this study was to evaluate whether maxillofacial fractures can be reliably detected and classified using ultra-low-dose CT.

View Article and Find Full Text PDF