Immobilization of purified pectinase from Aspergillus nidulans on chitosan and alginate beads for biotechnological applications.

Background: Because the process is cost-effective, microbial pectinase is used in juice clearing. The isolation, immobilization, and characterization of pectinase from Aspergillus nidulans (Eidam) G. Winter (AUMC No.

Plant-mediated green synthesis of gold nanoparticles using an aqueous extract of , optimization, characterizations, and their neuroprotective effect on propionic acid-induced autism in Wistar rats.

The current study was conducted to examine an innovative method for synthesizing gold nanoparticles (AuNPs) from an aqueous () . Furthermore, the synthesized AuNPs were used to explore their potential neuroprotective impact against propionic acid (PPA)-induced autism. A extract was used to achieve the synthesis of AuNPs.

Glucose transporter 1 deficiency, AMP-activated protein kinase activation and immune dysregulation in autism spectrum disorder: Novel biomarker sources for clinical diagnosis.

Unlabelled: The neurophysiological basis of autism spectrum disorder (ASD) is still uncertain. Nevertheless, studies support the hypotheses that oxidative stress, neuroinflammation, immune dysregulation, and metabolic stress are contributors. In this study, the serum levels of 3-nitrotyrosine (3-NT), hypoxia-inducible factor 1 α (HIF-1 α), heat shock protein 70 (HSP-70), interleukin-17A (IL-17A), IL-35, vitamin D3 (VITD), glucose transporter-1 (GUT1), and AMP-activated protein kinase (AMPK) were estimated in Saudi ASD children versus age-matched neurotypical controls, aiming to investigate whether these parameters have potential roles in the pathophysiologic mechanisms of ASD and hoping to find a reliable marker for early ASD diagnosis.

Clinical importance of zinc as monotherapy in modulating RT-PCR cycle threshold values and antibody levels in cases of COVID 19 patients.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is globally concerning for overall health. The viral burden is diagnosed by the positive cycle threshold value (Ct-value) of the real-time reverse transcription polymerase chain reaction (RT-PCR) assay. So far, no effective therapy has been established for this viral infection.

Strigolactones-a novel class of phytohormones as anti-cancer agents.

Chemotherapy shows some promising results in the inhibition of cancer, but resistance to chemotherapy and its severe side effects may occur in due course, resulting in only restricted and narrow benefits. Therefore, there is a pressing need to find alternative chemotherapeutic drugs for combating cancers. Plants have been used since ages in medicine, and by the dawn of 19th century, various potent and promising anti-cancer products have been derived from plants.

Mesenchymal stem cells: a future experimental exploration for recession of diabetic nephropathy.

Background: The progresses made in stem cell therapy offer an innovative approach and exhibit great potential for the repair of damaged organs and tissues. This study was conducted with a view to find the mechanisms responsible for the effectiveness of bone marrow-derived mesenchymal stem cells (BM-MSCs) in the suppression of diabetes and experimentally-induced diabetic nephropathy.

Methods: To realize this objective, diabetic and diabetic nephropathy subject groups that underwent MSC treatment were studied through numerous biochemistry and molecular genetics analyses.

Favorable effects of flaxseed supplemented diet on liver and kidney functions in hypertensive Wistar rats.

Hypertension is a major risk factor for cardiovascular diseases and is detrimental to several organs including the liver and kidneys. The flaxseed-derived polyunsaturated fatty acids including the omega-3 and omega-6 essential fatty acids have been shown to blunt the effects of hypertension. It is however, unclear whether the flaxseed, which is rich in these essential fatty acids, could improve the liver and kidney dysfunctions observed in the hypertensive condition.