A novel prognostic risk model for patients with refractory/relapsed acute myeloid leukemia receiving venetoclax plus hypomethylating agents.

Off-label hypomethylating agents and venetoclax (HMA/VEN) are often used for relapsed and refractory (R/R) AML patients. However, predictors of outcome are elusive. The objective of the current retrospective observational multicenter study of 240 adult patients (median age 68.

Three-dimensional digital imaging analysis of the palatal bone thickness for orthodontic mini-implant insertion - determination of the safe zone and angulation.

Background: In order to successfully perform orthodontic mini-implant procedures successfully for the subsequent anchoring of orthodontic appliances, it is crucial to know the palatal bone thickness. This is usually assessed using two-dimensional radiographs. The purpose of this study was to use a three-dimensional digital imaging measurement method to provide information on palatal bone volume and bone thickness and to make recommendations on the optimal and safe insertion site and angle for palatal mini-implants.

Accuracy of full-guided versus half-guided implant procedures carried out with digital implant planning software by students as part of a university curriculum.

Background: This in vitro study investigated whether full-guided (FG) or half-guided (HG) implant placement is more suitable for beginners and to what extent the use of the coDiagnostiX (CDX) (10.5, Straumann Group, Basel, Switzerland) implant planning software proves useful in teaching.

Methods: Twenty students planned implant positions with CDX which were then placed in a model using printed drill templates in the sense of FG implantation (group 1) and HG implantation (group 2).

Investigation of Morphological Changes of the Soft Tissue in the Aesthetic Zone: A 3D Virtual Analysis after Conventional Tooth Extraction and Benex Extraction.

Background: Postoperative resorption of hard and soft tissues occurs as a consequence of tooth extraction. The Benex-Control extractor allows minimally invasive extraction of the tooth without causing pronounced iatrogenic trauma. The aim of this study was to verify whether the resorption of the tissues after extraction can be reduced by using the Benex system compared to the conventional extraction method.

Early monitoring of inlay wear after total knee arthroplasty on plain radiographs using model-based wear measurement.

Wear of the ultra-high molecular-weight polyethylene (UHMWPE) component in total knee arthroplasty contributes to implant failure. It is often detected late, when patients experience pain or instability. Early monitoring could enable timely intervention, preventing implant failure and joint degeneration.

Stress Distribution within the Peri-Implant Bone for Different Implant Materials Obtained by Digital Image Correlation.

Stress distribution and its magnitude during loading heavily influence the osseointegration of dental implants. Currently, no high-resolution, three-dimensional method of directly measuring these biomechanical processes in the peri-implant bone is available. The aim of this study was to measure the influence of different implant materials on stress distribution in the peri-implant bone.

Effect of Luting Materials on the Accuracy of Fit of Zirconia Copings: A Non-Destructive Digital Analysis Method.

The marginal accuracy of fit between prosthetic restorations and abutment teeth represents an essential aspect with regard to long-term clinical success. Since the final gap is also influenced by the luting techniques and materials applied, this study analyzed the accuracy of the fit of single-tooth zirconia copings before and after cementation using different luting materials. Forty plaster dies with a corresponding zirconia coping were manufactured based on a single tooth chamfer preparation.

Three-dimensional imaging analysis of CAD/CAM custom-milled versus prefabricated allogeneic block remodelling at 6 months and long-term follow-up of dental implants: A retrospective cohort study.

Aim: This retrospective cohort study aimed to volumetrically investigate the bone stability rate of prefabricated allogeneic bone blocks (PBB) and computer-aided design (CAD)/computer-aided manufacturing (CAM) custom-milled allogeneic bone blocks (CCBB) for ridge augmentation.

Materials And Methods: Nineteen patients were treated with 20 allografts: 11 CCBB, 9 PBB; 10 in the maxilla and 10 in the mandible. Clinical treatment history and cone beam computed tomography scans before surgery (t), directly after graft surgery (t) and after 6 months of healing prior to implant insertion (t) were evaluated using a three-dimensional evaluation software for absolute bone volume, stability as well as vertical and horizontal bone gain.

Clonal relapse dynamics in acute myeloid leukemia following allogeneic hematopoietic cell transplantation.

Patients with acute myeloid leukemia (AML) who experience relapse following allogeneic hematopoietic cell transplantation (alloHCT) face unfavorable outcomes regardless of the chosen relapse treatment. Early detection of relapse at the molecular level by measurable residual disease (MRD) assessment enables timely intervention, which may prevent hematological recurrence of the disease. It remains unclear whether molecular MRD assessment can detect MRD before impending relapse and, if so, how long in advance.

Impact of Scanbody Geometry and CAD Software on Determining 3D Implant Position.

The implementation of CAD software in the digital production of implant prosthetics stands as a pivotal aspect of clinical dentistry, necessitating high precision in the alignment of implant scanbodies. This study investigates the influence of scanbody geometry and the method of superimposing in CAD software when determining 3D implant position. A standardized titanium model with three bone-level implants was digitized to create reference STL files, and 10 intraoral scans were performed on Medentika and NT-Trading scanbodies.

Radiopacity Enhancements in Polymeric Implant Biomaterials: A Comprehensive Literature Review.

Polymers as biomaterials possess favorable properties, which include corrosion resistance, light weight, biocompatibility, ease of processing, low cost, and an ability to be easily tailored to meet specific applications. However, their inherent low X-ray attenuation, resulting from the low atomic numbers of their constituent elements, i.e.

Incidence of occult appendiceal neoplasm in patients over 40 years with acute appendicitis: A single-institution review.

Objective: To investigate the incidence of occult appendiceal neoplasm in patients aged 40 years and over who underwent appendicectomy for appendicitis.

Methods: The clinical coding electronic database was used to identify patients aged 40 years and over who were diagnosed with appendicitis from September 2010 to September 2022. Patients were included if they were managed operatively.

Colorectal adenomatous and serrated polyps in rural South Australia: who, why, what and where?

Backgrounds: The adenoma-carcinoma and serrated pathways offer a window of opportunity for the removal of pre-malignant polyps and prevention of colorectal cancer (CRC) through the use of colonoscopy. The aim of this study was to investigate variation in polyp incidence in different age groups, gender and indications for undertaking colonoscopy. We also address histological types of polyps found and where in the bowel they are located.

Quantitative analysis of zirconia and titanium implant artefacts in three-dimensional virtual models of multi-slice CT and cone beam CT: does scan protocol matter?

Objectives: Artefacts from dental implants in three-dimensional (3D) imaging may lead to incorrect representation of anatomical dimensions and impede virtual planning in navigated implantology. The aim of this study was quantitative assessment of artefacts in 3D STL models from cone beam CT (CBCT) and multislice CT (MSCT) using different scanning protocols and titanium-zirconium (Ti-Zr) and zirconium (ZrO) implant materials.

Methods: Three ZrO and three Ti-Zr implants were respectively placed in the mandibles of two fresh human specimens.

MRD as Biomarker for Response to Donor Lymphocyte Infusion after Allogeneic Hematopoietic Cell Transplantation in Patients with AML.

Donor lymphocyte infusions (DLIs) can directly target leukemic cells through a graft-versus-leukemia effect and play a key role in the prevention and management of relapse after allogeneic hematopoietic cell transplantation (alloHCT). Predictors of response to DLIs are not well established. We evaluated measurable residual disease (MRD) before, 30 and 90 days after DLI treatment as biomarkers of response.

Deep Characterization and Comparison of Different Retrovirus-like Particles Preloaded with CRISPR/Cas9 RNPs.

The CRISPR/Cas system has a broad range of possible medical applications, but its clinical translation has been hampered, particularly by the lack of safe and efficient vector systems mediating the short-term expression of its components. Recently, different virus-like particles (VLPs) have been introduced as promising vectors for the delivery of CRISPR/Cas genome editing components. Here, we characterized and directly compared three different types of retrovirus-based (R) VLPs, two derived from the γ-retrovirus murine leukemia virus (gRVLPs and "enhanced" egRVLPs) and one from the lentivirus human immunodeficiency virus, HIV (LVLPs).

The role of screening colonoscopy after appendicitis in patients over 40 years of age.

Background: There is some evidence of the association between acute appendicitis and colorectal neoplasm in patients over the age of 40 years. Despite this, few centres routinely evaluate the colon endoscopically following an episode of appendicitis in these patients. Our aim was to investigate the incidence of colorectal neoplasm in patients aged 40 years and over who underwent screening colonoscopy following acute appendicitis.

Comparison of digital and visual tooth shade selection.

Objective: In dental restorations, color determination is very important for achieving esthetic results. The aim of this study was to compare visual shade selection using digital methods and to assess the repeatability of the utilized intraoral scanners.

Materials And Methods: In 31 probands, tooth color was determined on teeth 11, 13, and 16.

Comparison of Digital and Conventional Impressions Based on the 3D Fit of Crowns.

Purpose: To evaluate intraoral scanners, scannable impression materials, and conventional methods for impression-taking with regard to precision and accuracy.

Materials And Methods: Ten impressions per technique were initially taken from a cobalt-chromium (Co-Cr) master model (chamfer preparation for the maxillary right first molar) for fabricating Co-Cr crown copings. The test specimens, their respective metal master model, and the plaster casts from the conventional impressions were then digitized with the light-optical Atos Triple Scanner.

Trueness of full-arch dental models obtained by digital and conventional impression techniques: an in vivo study.

The aim of this study was to compare the trueness of complete- and partial-arch impressions obtained using conventional impression materials and intraoral scanners in vivo. Full-arch impressions were taken using polyether and polyvinylsiloxane. Gypsum casts were digitized using a laboratory scanner (IM, AF).

Molecular response patterns in relapsed/refractory AML patients treated with selinexor and chemotherapy.

Relapse in patients with acute myeloid leukemia (AML) is common and is associated with a dismal prognosis. Treatment options are limited and the understanding of molecular response patterns is still challenging. We analyzed the clonal response patterns of 15 patients with relapsed/refractory AML treated with selinexor in a phase II trial (SAIL).

Outcomes of laparoscopic colorectal cancer surgery in a non-metropolitan Australian hospital: audit of 120 patients with long-term follow-up results.

Background: Laparoscopic colorectal cancer surgery has been shown to produce comparable oncological long-term results as well as improved short-term outcomes compared to open surgery in multicentre trials. Limited information is available whether these results are reproduced in non-metropolitan surgery.

Methods: Audit of prospectively collected follow-up data in a rural surgical centre in South Australia.