Salvianolic Acid A Suppresses DNCB-Induced Atopic Dermatitis-Like Symptoms in BALB/c Mice.

Prevalence of atopic dermatitis (AD), a chronic, pruritic, and relapsing inflammatory skin disorder, is growing. Because available therapeutics is limited, immune regulators from natural resources could be helpful for treating AD symptoms. The root of Bunge (Lamiaceae) has been studied for the treatment of inflammatory diseases, including dermatologic disorders in Korea.

Suppressive Effect of CYM50358 S1P Antagonist on Mast Cell Degranulation and Allergic Asthma in Mice.

Levels of sphingosine 1-phosphate (S1P), an intercellular signaling molecule, reportedly increase in the bronchoalveolar lavage fluids of patients with asthma. Although the type 4 S1P receptor, S1P has been detected in mast cells, its functions have been poorly investigated in an allergic asthma model . S1P functions were evaluated following treatment of CYM50358, a selective antagonist of S1P, in an ovalbumin-induced allergic asthma model, and antigen-induced degranulation of mast cells.