Publications by authors named "Whitney L Browning"
For more than 4 decades, pediatricians have sought the best practices for effectively managing well-appearing young febrile infants. In 2021, the American Academy of Pediatrics released a clinical practice guideline for the management of well-appearing febrile infants aged 8 to 60 days. The guideline incorporates advancements in testing, such as biomarkers and diagnostic testing in the setting of changing epidemiology, to help risk stratify infants in the newly formed group age 22 to 28 days as well as the group age 29 to 60 days.
View Article and Find Full Text PDFArticle Synopsis
- A study was conducted to investigate how often neurological complications occur in children hospitalized due to influenza, involving 29,676 patients from 49 children's hospitals between 2015 and 2020.
- Out of the hospitalized children, 7.6% experienced neurologic issues, with febrile seizures being the most common, and these complications resulted in longer hospital stays, higher ICU admissions, and increased costs.
- Risk factors for developing neurological complications included being male, Asian race/ethnicity, and having a chronic neurological condition, highlighting the need for targeted influenza prevention strategies in high-risk groups.
Article Synopsis
- A study investigated how often children are prescribed medications in U.S. hospitals that could interact negatively with each other.
- Researchers analyzed data from over 47,000 hospitalizations across 52 children's hospitals from 2016 to 2018, finding that 2.0% of these cases involved potentially serious drug interactions.
- The risk of prescribing such medications differed greatly among hospitals and was linked to factors like patient age and the complexity of their health conditions, highlighting a need for further research on safety measures in medication use.
Objectives: To derive and internally validate a prediction model for the identification of febrile infants ≤60 days old at low probability of invasive bacterial infection (IBI).
Methods: We conducted a case-control study of febrile infants ≤60 days old who presented to the emergency departments of 11 hospitals between July 1, 2011 and June 30, 2016. Infants with IBI, defined by growth of a pathogen in blood (bacteremia) and/or cerebrospinal fluid (bacterial meningitis), were matched by hospital and date of visit to 2 control patients without IBI.
Objectives: To help guide empiric treatment of infants ≤60 days old with suspected invasive bacterial infection by describing pathogens and their antimicrobial susceptibilities.
Study Design: Cross-sectional study of infants ≤60 days old with invasive bacterial infection (bacteremia and/or bacterial meningitis) evaluated in the emergency departments of 11 children's hospitals between July 1, 2011 and June 30, 2016. Each site's microbiology laboratory database or electronic medical record system was queried to identify infants from whom a bacterial pathogen was isolated from either blood or cerebrospinal fluid.
Objectives: The Rochester criteria were developed to identify febrile infants aged 60 days or younger at low-risk of bacterial infection and do not include cerebrospinal fluid (CSF) testing. Prior studies have not specifically assessed criteria performance for bacteremia and bacterial meningitis (invasive bacterial infection). Our objective was to determine the sensitivity of the Rochester criteria for detection of invasive bacterial infection.
View Article and Find Full Text PDFObjectives: To assess hospital differences in empirical antibiotic use, bacterial epidemiology, and antimicrobial susceptibility for common antibiotic regimens among young infants with urinary tract infection (UTI), bacteremia, or bacterial meningitis.
Methods: We reviewed medical records from infants <90 days old presenting to 8 US children's hospitals with UTI, bacteremia, or meningitis. We used the Pediatric Health Information System database to identify cases and empirical antibiotic use and medical record review to determine infection, pathogen, and antimicrobial susceptibility patterns.
Background: Administrative data can be used to determine optimal management of febrile infants and aid clinical practice guideline development.
Objective: Determine the most accurate International Classification of Diseases, Ninth Revision (ICD-9) diagnosis coding strategies for identification of febrile infants.
Design: Retrospective cross-sectional study.
Objective: To determine pediatric hospitalists' perceptions about residents' effects on cost and quality of care and their own ability to provide and teach cost-effective, high-quality care.
Methods: A 15-item survey assessing hospitalist perceptions of resident impact on costs/quality and their role in teaching cost-effectiveness was developed and sent to 180 hospitalists from 113 institutions in the United States.
Results: Of 180 hospitalists surveyed, 127 completed surveys (71%).
Background: Differences among febrile infant institutional clinical practice guidelines (CPGs) may contribute to practice variation and increased healthcare costs.
Objective: Determine the association between pediatric emergency department (ED) CPGs and laboratory testing, hospitalization, ceftriaxone use, and costs in febrile infants.
Design: Retrospective cross-sectional study in 2013.