Publications by authors named "Whitney E Muhlestein"

Background: Transfer of a healthy C7 spinal nerve is a tool for upper extremity reanimation in patients with severe brachial plexus injury (BPI). Its use remains controversial owing to concern for neurological injury to the donor arm. Utilizing wearable motion-sensor technology, we aimed to quantify donor arm morbidity after C7 spinal nerve harvest in patients with pan-BPI, reporting both the time and magnitude of donor arm movement in a real-world setting compared to healthy controls.

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Article Synopsis
  • Neonatal brachial plexus palsy (NBPP) affects arm movement, and this study investigates how the timing of nerve surgery impacts long-term recovery.
  • Researchers analyzed data from children who had surgery for NBPP between 2005 and 2020, comparing those who had surgery at younger vs. older ages.
  • Results showed that surgery before 9 months old is linked to better recovery in shoulder and elbow movement over time, suggesting that early referral for surgery is important for optimal outcomes.
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Background And Objectives: There is a relative dearth of published data with respect to recovery of upper extremity movement after nerve reconstruction for neonatal brachial plexus palsy (NBPP). This study aimed to demonstrate long-term recovery of active range of motion (AROM) at the shoulder, elbow, and forearm after nerve reconstruction for NBPP and to compare that with patients managed nonoperatively.

Methods: We interrogated a prospectively collected database of all patients evaluated for NBPP at a single institution from 2005 to 2020.

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Article Synopsis
  • The study investigates the use of wearable motion sensor technology to measure spontaneous arm movement in adult patients with traumatic pan-brachial plexus injury (pBPI) after surgical reconstruction.
  • It included 29 patients who wore accelerometers on both arms for a week to gauge the usage of their affected arm compared to the healthy one, collecting data on movement intensity and frequency.
  • The results indicated that, on average, patients utilized their injured arm about 50% as much as their uninjured arm, suggesting that the technology effectively captures real-world functional recovery over traditional clinical measures.
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Background: There is a strong need for the development of core outcome sets (COS) across nerve surgery to allow for improved data synthesis, meta-analyses, and reporting consistency. Development of a core outcome set typically starts with assessing the literature for previously reported outcome measures. Common peroneal neuropathy (CPN) is the most common compressive mononeuropathy of the lower extremity and can result in pain, motor, and sensory deficits.

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Aim: To demonstrate the trajectory of long-term recovery of upper-extremity movement and determine optimal timing of evaluation at multidisciplinary specialty centers in children with neonatal brachial plexus palsy (NBPP).

Method: All children with conservatively managed NBPP seen at one institution from 2005 to 2020 were considered for inclusion. The cohort was divided according to age at formal evaluation (≤30 or > 30 days).

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The highest-impact medical literature is increasingly produced by interdisciplinary teams. The field of neurosurgery, which involves complex pathologies and recoveries, is particularly amenable to interdisciplinary research approaches. However, research in the medical context regarding the characteristics of effective teams, as well as how to develop and maintain interdisciplinary teams, remains lacking.

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Background: Cushing disease represents a challenge for neurosurgeons, with high recurrence rates reported. Characteristics associated with remission are incompletely understood; thus, an intraoperative predictor for outcome would be valuable for assessing resection of adrenocorticotropic hormone (ACTH) secreting tissue.

Objective: To evaluate whether intraoperative ACTH measurement could predict outcome after surgery for Cushing disease.

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Neonatal brachial plexus palsy describes injury to the brachial plexus in the perinatal period, resulting in motor and sensory deficits of the upper arm. Nerve reconstruction, including graft repair and nerve transfers, can be used to restore function in patients whose injury does not respond to conservative management. Despite the availability of these techniques, 30%-40% of children have lifelong disability, reflecting a 10-fold underutilization of surgery.

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Article Synopsis
  • Acute flaccid myelitis (AFM) is a serious neurological condition primarily affecting children, leading to limb weakness and paralysis, with no standardized treatment protocols established despite heightened awareness since 2014.
  • A systematic review analyzed 99 articles, revealing a strong association between AFM and nonpolio enterovirus infections, with common clinical signs including viral symptoms, spinal cord lesions, and sudden onset of weakness.
  • Management strategies emphasize supportive care and rehabilitation, with emerging evidence suggesting that nerve transfer surgery may improve functionality in patients with ongoing weakness.
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Objective: Standard, physician-elicited clinical assessment tools for the evaluation of function after nerve reconstruction for neonatal brachial plexus palsy (NBPP) do not accurately reflect real-world arm function. Wearable activity monitors allow for the evaluation of patient-initiated, spontaneous arm movement during activities of daily living. In this pilot study, the authors demonstrate the feasibility of using body-worn sensor technology to quantify spontaneous arm movement in children with NBPP 10 years after nerve reconstruction and report the timing and magnitude of recovered arm movement.

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With increasing use of intracranial imaging, the diagnosis of benign intracranial cysts is becoming more frequent in the pediatric population. These lesions are usually incidentally discovered during the work-up of unrelated symptoms. Most do not require treatment and many do not even require imaging follow-up.

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