Aspirin, nonsteroidal anti-inflammatory drugs, and the risks of cancers of the esophagus.

Background: Frequent consumption of aspirin and nonsteroidal anti-inflammatory drugs (NSAID) has been associated with reduced occurrence of cancers of the esophagus, although potential modifying effects of other causal factors remain relatively unexplored.

Methods: We compared nationwide samples of Australian patients with adenocarcinomas of the esophagus (EAC; n = 367) or esophagogastric junction (EGJAC; n = 426) or esophageal squamous cell carcinoma (ESCC; n = 309) with control participants sampled from a population register (n = 1,580). Intakes of aspirin, other NSAIDs, and acetaminophen (paracetamol) were assessed from self-reports.

Associations of duration, intensity, and quantity of smoking with adenocarcinoma and squamous cell carcinoma of the esophagus.

Smoking has been identified as a risk factor for esophageal cancer; however, there is evidence that magnitudes and patterns of association differ by histologic type. The authors aimed to measure and compare the independent effects of various dimensions of smoking (duration, intensity, total dose, and time since quitting) on risks of esophageal adenocarcinoma (EAC), gastroesophageal junction adenocarcinoma (GEJAC), and esophageal squamous cell carcinoma (ESCC). They used data from a population-based Australian case-control study (2002-2005) comprising 367 EAC cases, 426 GEJAC cases, and 309 ESCC cases and 1,580 controls.

Body size and risk of epithelial ovarian and related cancers: a population-based case-control study.

Different subtypes of ovarian cancer appear to have different causes; however, the association between body mass index (BMI) and the different subtypes is unclear. We examined the associations between body-mass index (BMI) and weight gain and risk of the different histological subtypes of epithelial ovarian cancer in a case-control study in Australia. Cases aged 18-79 with a new diagnosis of invasive epithelial ovarian cancer (n = 1,269) or borderline tumor (n = 311) were identified through a network of clinics and cancer registries throughout Australia.

Changes in the incidence of cutaneous melanoma in the west of Scotland and Queensland, Australia: hope for health promotion?

We compared trends in melanoma incidence by body site in two populations exposed to different levels of sunlight and different approaches to melanoma prevention. We analysed site-specific melanoma incidence during the period 1982-2001 in Queensland, Australia (n=28 862 invasive melanomas; 2536 lentigo maligna melanomas) and the west of Scotland (n=4278 invasive melanomas; 525 lentigo maligna melanomas). Analyses were stratified by sex and age group (<40 years, 40-59 years, >/=60 years).

Single nucleotide polymorphisms in obesity-related genes and the risk of esophageal cancers.

Rates of adenocarcinoma of the esophagus (EAC) and esophagogastric junction (EGJAC) have been rising rapidly in recent decades, in contrast to the declining rates of esophageal squamous cell carcinomas (ESCC). Obesity is a major risk factor for both EAC and EGJAC, but not ESCC, and there is speculation that obesity promotes adenocarcinoma development through endocrine and related pathways. We therefore compared the prevalence of 12 single nucleotide polymorphisms (SNPs) in nine candidate genes previously implicated in obesity pathways (LEP, LEPR, ADIPOQ, POMC, PPARalpha, PPARgamma, RXRgamma, GHRL, and INSIG2) in a large Australian case-control study comprising DNA samples from 260 EAC cases, 301 EGJAC cases, 213 ESCC cases, and 1,352 population controls.

Reduced expression of IL-18 is a marker of ultraviolet radiation-induced melanomas.

We previously showed that mice carrying an activated Cdk4 mutation together with melanocyte-specific mutant Hras (Cdk4(R24C/R24C)/TPras) develop melanoma spontaneously, but penetrance is increased and age of onset reduced after neonatal ultraviolet radiation (UVR) exposure. UVR-treated mice were more likely to develop multiple primary lesions, and these melanomas more often expressed Trp53, and less often expressed c-Myc, than melanomas from nonirradiated mice (Hacker et al., Cancer Res 2006;66:2946-52).

Polymorphisms in MGMT and DNA repair genes and the risk of esophageal adenocarcinoma.

Rates of adenocarcinoma of the esophagus (EAC) and esophago-gastric junction (EGJAC) have increased rapidly in recent decades. The primary risk factors, gastro-esophageal acid reflux and smoking, are potentially genotoxic through the generation of N-nitroso compounds. The DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) is the major cellular defense against alkylating DNA damage.

The Queensland Study of Melanoma: environmental and genetic associations (Q-MEGA); study design, baseline characteristics, and repeatability of phenotype and sun exposure measures.

Cutaneous malignant melanoma (CMM) is a major health issue in Queensland, Australia, which has the world's highest incidence. Recent molecular and epidemiologic studies suggest that CMM arises through multiple etiological pathways involving gene-environment interactions. Understanding the potential mechanisms leading to CMM requires larger studies than those previously conducted.

Performance modeling of an airborne Raman water-vapor lidar.

We have developed a sophisticated Raman lidar numerical model to simulate the performance of two ground-based Raman water-vapor lidar systems. After verifying the model using these ground-based measurements, we then used the model to simulate the water-vapor measurement capability of an airborne Raman lidar under both daytime and nighttime conditions for a wide range of water-vapor conditions. The results indicate that, under many circumstances, the daytime measurements possess comparable quality to an existing airborne differential absorption water-vapor lidar whereas the nighttime measurements have improved spatial and temporal resolution.

Application of statistical methods to the determination of slope in lidar data.

Assumptions made in the analysis of both Raman lidar measurements of aerosol extinction and differential absorption lidar (DIAL) measurements of an absorbing species are tested. Statistical analysis techniques are used to enhance the estimation of aerosol extinction and aerosol extinction error that is usually handled using a linear model. It is determined that the most probable extinction value can differ from that of the linear assumption by up to 10% and that differences larger than 50% can occur in the calculation of extinction error.

Measurement of an isosbestic point in the Raman spectrum of liquid water by use of a backscattering geometry.

Measurements presented here confirm that a temperature-insensitive point occurs in the backscattered Raman spectrum from liquid water. This result, coupled with existing laboratory measurements of Raman scattering from liquid droplets, indicates that a Raman lidar measurement of cloud liquid water is feasible.

Alcohol intake is significantly associated with atrial flutter in patients under 60 years of age and a shorter right atrial effective refractory period.

Background: Although evidence suggests that alcohol is associated with atrial fibrillation (AF), the association between alcohol and atrial flutter (AFL) has not been examined. The mechanism connecting alcohol and atrial arrhythmias is unknown.

Methods: Alcohol intake was determined in 195 consecutive patients with AF and AFL.

Markers of inflammation before and after curative ablation of atrial flutter.

Background: Atrial arrhythmias are associated with inflammation. The cause and effect of the association are unknown.

Objective: The purpose of this study was to test the hypothesis that atrial tachyarrhythmias contribute to inflammation.

Cancers of the esophagus and carbonated beverage consumption: a population-based case-control study.

Objective: Increased consumption of carbonated soft drinks has been hypothesized to be a risk factor for esophageal adenocarcinoma (EAC); however, previous studies have not found supportive evidence. We analyzed data from a population-based case-control study to measure the association between carbonated beverage intake and risk of adenocarcinomas and squamous cell carcinoma (SCC) of the esophagus.

Methods: A food frequency questionnaire (FFQ) was used to collect data on carbonated soft drink and beer consumption; a self-administered questionnaire was used to collect information on demographic, socioeconomic, and lifestyle-related factors from 1,484 control subjects, 294 cases with EAC, 325 cases with adenocarcinoma of the esophagogastric junction (EGJAC), and 238 cases with SCC of the esophagus.

Progesterone receptor variation and risk of ovarian cancer is limited to the invasive endometrioid subtype: results from the Ovarian Cancer Association Consortium pooled analysis.

There is evidence that progesterone plays a role in the aetiology of invasive epithelial ovarian cancer. Therefore, genes involved in pathways that regulate progesterone may be candidates for susceptibility to this disease. Previous studies have suggested that genetic variants in the progesterone receptor gene (PGR) may be associated with ovarian cancer risk, although results have been inconsistent.

Leptin and the risk of Barrett's oesophagus.

Background: Obesity is associated with increased risks of Barrett's oesophagus and oesophageal adenocarcinoma. Alterations in serum leptin and adiponectin, obesity-related cytokines, have been linked with several cancers and have been postulated as potential mediators of obesity-related carcinogenesis; however, the relationship with Barrett's oesophagus remains unexplored.

Methods: Serum leptin and adiponectin concentrations were measured on two subsets of participants within a case-control study conducted in Brisbane, Australia.

Remote detection of Raman scattering by use of a holographic optical element as a dispersive telescope.

We describe the retrieval of nighttime lidar profiles by use of a large holographic optical element to simultaneously collect and spectrally disperse Raman-shifted return signals. Results obtained with a 20-Hz, 6-mJ/pulse , frequency-tripled Nd:YAG source demonstrate profiles for atmospheric nitrogen with a range greater than 1 km for a time average of 26 s.

Serous ovarian, fallopian tube and primary peritoneal cancers: a comparative epidemiological analysis.

Invasive serous cancers are diagnosed in the ovary, fallopian tube and peritoneum. It is widely believed that these are variants of the same malignancy but little is known about fallopian tube and primary peritoneal cancers. A comparison of risk factors for these tumor types may shed light on common or distinct aetiological pathways involved in these types of cancer.

Recreational physical activity and epithelial ovarian cancer: a case-control study, systematic review, and meta-analysis.

It remains unclear whether physical activity is associated with epithelial ovarian cancer risk. We therefore examined the association between recreational physical activity and risk of ovarian cancer in a national population-based case-control study in Australia. We also systematically reviewed all the available evidence linking physical activity with ovarian cancer to provide the best summary estimate of the association.

SiDCoN: a tool to aid scoring of DNA copy number changes in SNP chip data.

The recent application of genome-wide, single nucleotide polymorphism (SNP) microarrays to investigate DNA copy number aberrations in cancer has provided unparalleled sensitivity for identifying genomic changes. In some instances the complexity of these changes makes them difficult to interpret, particularly when tumour samples are contaminated with normal (stromal) tissue. Current automated scoring algorithms require considerable manual data checking and correction, especially when assessing uncultured tumour specimens.

Combined effects of obesity, acid reflux and smoking on the risk of adenocarcinomas of the oesophagus.

Objective: To measure the relative risks of adenocarcinomas of the oesophagus and gastro-oesophageal junction associated with measures of obesity, and their interactions with age, sex, gastro-oesophageal reflux symptoms and smoking.

Design And Setting: Population-based case-control study in Australia.

Patients: Patients with adenocarcinomas of the oesophagus (n = 367) or gastro-oesophageal junction (n = 426) were compared with control participants (n = 1580) sampled from a population register.

Diagnosing skin cancer in primary care: how do mainstream general practitioners compare with primary care skin cancer clinic doctors?

Objective: To measure and compare the casemix and diagnostic accuracy of excised or biopsied skin lesions managed by mainstream general practitioners and doctors within primary care skin cancer clinics.

Design, Setting And Participants: Prospective comparative study of 104 GPs and 50 skin cancer clinic doctors in south-eastern Queensland, involving 28 755 patient encounters. The study was conducted in 2005.

Risk factors for benign, borderline and invasive mucinous ovarian tumors: epidemiological evidence of a neoplastic continuum?

Objective: Some molecular and histological evidence suggests that mucinous epithelial ovarian cancers develop via a sequence from benign tumor through borderline tumor to invasive cancer. Such a sequence would predict some shared risk factors between the different tumor types. To investigate this, we examined risk factors for benign, borderline and invasive mucinous ovarian tumors.

Sun protection and low levels of vitamin D: are people concerned?

Objective: Recent reports on the association between low serum vitamin D and increased risk of cancer raised concerns about possible adverse effects of primary prevention strategies for skin cancer. To evaluate if these reports may influence peoples' sun protective behavior, knowledge, and attitudes to the impact of sun protection on vitamin D.

Methods: Within a population-based survey in Queensland, Australia (5,611 participants, mean age 50.