Preparation and Evaluation of Aminomalononitrile-Coated Ca-Sr Metal-Organic Frameworks as Drug Delivery Carriers for Antibacterial Applications.

After orthopedic surgery, antibiotics are usually employed to reduce the risk of infection. If it is possible to enhance antimicrobial functionality and incorporate antimicrobial agents into the bone-filling matrix, not only it can promote bone tissue regeneration, but it can also enable localized administration of medication to elevate antibacterial efficacy. Meanwhile, previous studies have shown that calcium and strontium can support the growth of osteoblastic cells and diminish bone resorption or deterioration.

Influence of the Components and Orientation of Hydroxyapatite Fibrous Substrates on Osteoblast Behavior.

Synthetic hydroxyapatite has good biocompatibility, bioactivity and osteoconductive ability because its chemical properties and biological properties are similar to those of bioapatite in bone tissue. Strontium-substituted hydroxyapatite has better degradability than hydroxyapatite and can both promote osteogenesis and inhibit adipogenesis in mesenchymal stem cells. Hence, hydroxyapatite and strontium-substituted hydroxyapatite are widely used as bone graft materials, cell carriers and drug/gene delivery carriers.

The Impact of Implantoplasty in Regenerated and Nonregenerated Treatment Modalities in Peri-implantitis: A Systematic Review and Meta-analysis.

Purpose: To investigate the impact of implantoplasty (IP) with or without regenerative procedures on treatment outcomes of peri-implantitis.

Materials And Methods: Electronic and manual literature searches were conducted for clinical trials published up to October 2020 that evaluated clinical outcomes (at least 6-month follow-up) after peri-implantitis treatment involving IP. The implant survival rate and clinical parameters (eg, probing depth [PD], bleeding on probing [BOP], marginal bone loss [MBL], clinical attachment level [CAL], and mucosal recession [REC]) at baseline and follow-ups were extracted from original articles for qualitative analyses.

Assessment of a Novel Alveolar Ridge Preservation Concept in Dehiscence Sockets: A Pilot Study.

In this prospective pilot study on ridge preservation (RP), a collagen sponge was placed to fill the bottom half of the socket, followed by a sequence of bone graft, collagen membrane, and a sponge placed on top. Twelve patients with 13 hopeless posterior teeth were included. Changes in bone dimension (including variations of horizontal ridge width [HRW] and bone height [BH]) between the time immediately postextraction (T) and 6 months later (T) were evaluated through CBCT.

The Effect of Strontium-Substituted Hydroxyapatite Nanofibrous Matrix on Osteoblast Proliferation and Differentiation.

Natural bone tissue consists primarily of bioapatite and collagen. Synthetic hydroxyapatite (HA) possesses good biocompatibility, bioactivity, and osteoconductivity due to its chemical and biological similarity to bioapatite. Hence, HA has been widely used as a bone graft, cell carrier and drug/gene delivery carrier.

Comparison of 4 sinus augmentation techniques for implant placement with residual alveolar bone height ≤3 mm.

This study compared implant outcomes following maxillary sinus floor augmentation (MSFA) in edentulous patients with a residual alveolar bone height ≤3 mm. Four techniques were evaluated: 1-stage bone-added osteotome sinus floor elevation procedure (BAOSFE) with simultaneous implant placement; 2-stage BAOSFE with delayed implant placement; 1-stage lateral window sinus floor elevation with simultaneous implant placement; and 2-stage lateral window sinus floor elevation with delayed implant placement. Patients were followed for 18 to 72 months (mean: 52.

Grafted bone remodeling following transcrestal sinus floor elevation: A cone-beam computed tomography study.

Background: Transcrestal sinus floor elevation is a reliable procedure when additional bone height is needed for maxillary implant placement. However, the grafted bone undergoes remodeling and the dimensional stability of grafted bone height may be affected by several clinical factors, including graft material, sinus anatomy and the morphology of grafted space.

Methods: This retrospective study examined patients who had undergone transcrestal sinus floor elevation with synthetic biphasic calcium phosphate and single implant placement.

Gelatin Hydrogels Reinforced by Absorbable Nanoparticles and Fibrils Cured by Visible Light for Tissue Adhesive Applications.

Most gelatin hydrogels used in regenerative medicine applications today are fabricated by photocrosslinking due to the convenience and speed of this method. However, in most cases photoinitiators are used, which require UV light, which, in turn, can cause cell and tissue damage, or using functionalized gelatin. Recently, ruthenium (II) tris-bipyridyl chloride has been studied as an initiator that can induce dityrosine bond formation using visible light.

Is History of Periodontal Disease Still a Negative Risk Indicator for Peri-implant Health Under Supportive Post-implant Treatment Coverage? A Systematic Review and Meta-analysis.

Purpose: Among all previous studies, history of periodontitis (HP) has been regarded as a negative indicator for peri-implant health. However, the role of HP under regular supportive post-implant treatment (SPT) has not yet been evaluated. The aim of this review was to evaluate whether HP remains a negative indicator even under regular SPT in terms of clinical outcomes.

Cone-beam computed tomography assessment of Schneiderian membranes: Non-infected and infected membranes, and membrane resolution following tooth extraction: A retrospective clinical trial.

Background: Cone-beam computed tomography (CBCT) presurgical assessment on the maxillary sinus can reduce the possibility of Schneiderian membrane perforation. This study examined Schneiderian membrane thickness (SMT) and its relationship with neighboring hard tissues for patients with and without membrane thickening. For patients with sinus infections, we evaluated dimensional changes of the SMT post-extraction relative to pre-extraction SMT and residual bone height (RBH).

The effect of supportive care in preventing peri-implant diseases and implant loss: A systematic review and meta-analysis.

Objective: To evaluate the influence of supportive treatment (SPT) during a maintenance period after implant placement on implant survival rate (SR) and incidence of peri-implant diseases.

Material And Methods: A systemic literature search for studies published up to June 2018 was conducted by two independent reviewers using Pubmed/MEDLINE, EMBASE, and Cochrane Central databases. Clinical controlled trials (CCT) involved in SPT protocol with more than 1-year follow-up were included.

Effect of Platelet-Rich Fibrin on Ridge Preservation in Perspective of Bone Healing: A Systematic Review and Meta-analysis.

Purpose: Among all platelet concentrates, platelet-rich fibrin has been shown to possess fibrin, leukocytes, and a variety of growth factors that could promote wound healing. The purpose of this study was to compare the bone healing in natural healing sockets (control group) versus that in sockets under ridge preservation with platelet-rich fibrin alone (test group).

Materials And Methods: Searches were conducted via electronic and manual approaches for randomized controlled trials and controlled clinical trials published up to May 2018 that evaluated alveolar ridge outcomes (at least 1-month follow-up) in both natural healing sites and sites with platelet-rich fibrin placement alone for ridge preservation.

Facial Fenestration and Dehiscence Defects Associated With Immediate Implant Placement Without Flap Elevation in Anterior Maxillary Ridge: A Preliminary Cone Beam Computed Tomography Study.

Purpose: To examine cone beam computed tomography (CBCT) anatomical findings, such as the concavity of the ridge and angulation of the tooth and alveolar ridge, either facial or palatal, in order to assess the potential clinical risks of performing flapless implant surgery.

Materials And Methods: CBCT images that met the inclusion criteria were examined. All images in maxillary anterior areas (canine to canine), facial bone thickness at 3 and 5 mm from the cementoenamel junction (CEJ), angulation of the tooth and alveolar ridge (Angle T: the angulation between the long axis of the tooth and the palatal plane; Angle D: the angulation between the long axis of the tooth and the midline of the ridge), the deepest point of facial concavity, the distance from the deepest point of facial concavity to the apex of the tooth and alveolar bone crest, nasopalatine canal, dehiscence, and fenestrations were measured and statistically analyzed.

Nonsurgical periodontal treatment and prosthetic rehabilitation of a renal transplant patient with gingival enlargement: a case report with 2-year follow-up.

Background: Drug-induced gingival enlargement is a common condition which can be observed in patients taking immunosuppressive medications following organ transplant surgery. The disfiguring excessive tissue often hinders proper oral hygiene practices, therefore accompanied by periodontitis, tooth mobility, and even pathological tooth migration in extreme cases. This case report presents a conservative treatment protocol for a patient with the aforementioned conditions involving neither surgical nor orthodontic intervention.

Impact of timing on soft tissue augmentation during implant treatment: A systematic review and meta-analysis.

Background: To achieve a predictable esthetic and functional outcome, soft tissue augmentation has become popular in implant treatment.

Objectives: The aim of this systematic review and meta-analysis was to assess the influence of different timing for soft tissue augmentation during implant treatment on soft tissue conditions and its stability.

Material And Methods: Electronic and manual searches for articles written in English up to September 2017 were performed by two independent reviewers.

Strontium ranelate treatment in a postmenopausal woman with osteonecrosis of the jaw after long-term oral bisphosphonate administration: a case report.

Bisphosphonates (BPs) suppress bone resorption and increase bone strength, thus reducing the risk of fracture. Oral BPs are widely used for the prevention and treatment of osteoporosis and osteopenia. Here, we describe the case of a postmenopausal woman who took oral alendronate for >3 years for osteoporosis.

Evaluation of the Mandibular Lingual Canal and Anterior Loop Length to Minimize Complications Associated With Anterior Mandibular Surgeries: A Cone-Beam Computed Tomography Study.

Purpose: This retrospective study evaluated the localization, incidence, and dimensions of the mandibular lingual canal and the anterior loop in the Taiwanese population using the simulation and visual interpretation of cone-beam computed tomography to minimize complications during symphysis block surgical procedures.

Materials And Methods: The sample population consisted of 215 patients (105 men and 110 women; mean age, 57 yr). The median lingual canal, symphysis bone thickness, and anterior loop length were defined and calculated using cone-beam computed tomography and 3-dimensional reconstructed images.

Association between maternal periodontal disease and preterm delivery and low birth weight.

Objective: It has been suggested that periodontal disease is an important risk factor for preterm low birth weight (PLBW). The purpose of this study was to determine the association of maternal periodontitis with low birth weight (LBW) and preterm birth (PB).

Materials And Methods: Pregnant women (n = 211) aged 22-40 years were enrolled while receiving prenatal care.

Factors influencing the presence of interproximal dental papillae between maxillary anterior teeth.

Background: The presence of interdental papillae in the maxillary anterior region plays a key esthetic role. The aim of this study is to investigate the impact of demographic variables, such as gender and ages, and radiographic measurements of interdental area anatomy on the presence of interdental papillae.

Methods: Periapical radiographs of 102 interdental papillae between maxillary anterior teeth were obtained in 30 adults who had fully erupted permanent dentition, healthy gingiva, and well-aligned maxillary anterior teeth.

Bone graft necrosis of facial translocation: comparison of 3 different techniques.

Objective: To compare the viability of translocated facial bone grafts among 3 different techniques of facial translocation: free bone graft (FBG), attached bone graft (ABG), and modified facial translocation (MFT).

Study Design: A total of 107 patients were divided into 3 groups: FBG group without reconstruction (N = 33), ABG group (N = 14), and FBG group with reconstruction using a flap (FBG[R+] and MFT) (N = 60). Data evaluated included the respective incidence of bone graft necrosis (BGN) and the impact of radiotherapy.

Lateral nasal wall mucoperiosteal flap: a versatile new reconstruction of the inner defect of translocated facial bone segments.

From July 1998 to December 2002, 42 patients (including 29 patients who had undergone radiation therapy) underwent a newly designed lateral nasal wall mucoperiosteal flap pedicled anteriorly on the lateral nasal artery of the angular artery to resurface a translocated facial bone segment during a facial translocation approach to the skull base to prevent its avascular necrosis. Of the 42 patients studied, 1 patient had full-thickness flap loss that resulted in bone graft necrosis. Another patient had marginal necrosis.

Surgical intervention of mucosal fenestration in a maxillary premolar: a case report.

Labial mucosal fenestration of the root apex is an uncommon occurrence. An unusual case involving a maxillary right first premolar is described. When presented, the tooth was nonvital with the buccal root apex readily seen through a soft tissue and bone fenestration.

The use of the facial translocation technique in the management of tumors of the paranasal sinuses and skull base.

Objective: We sought to assess the efficacy of facial translocation in the management of tumors of the skull base and paranasal sinuses.

Study Design And Setting: From July 1993 to December 1999, 75 patients, aged 3 to 102 years old, underwent facial translocation. Thirty-three (44%) patients also underwent a combined neurosurgical procedure.

Complications of mandibulotomy: midline versus paramidline.

Objective: Mandibulotomy is an important surgical approach to oral cavity and oropharynx. The objective of this study was to evaluate the related complications of 2 common mandibulotomies: midline (osteotomy between 2 central incisors) and paramidline (osteotomy between lateral incisor and canine).

Study Design: Ninety-six patients who had cancer in the oral cavity or oropharynx had preoperative evaluation of the mandible with panoramic films.

The anatomical basis for mandibulotomy: midline versus paramidline.

Objective: To provide an anatomical basis for mandibulotomy.

Study Design: Prospective.

Methods: The angles between the long axis of the two mandibular central incisors and between the lateral incisor and canine and the corresponding root length were measured in panoramic films of 50 Taiwanese patients who had oral or oropharyngeal carcinomas.