Reliability of running gait variability measures calculated from inertial measurement units.

Changes to the variability within biomechanical signals may reflect a change in the health of the human system. However, for running gait variability measures calculated from wearable device data, it is unknown whether a between-day difference reflects a shift in system dynamics reflective of a change in human health or is a result of poor between-day reliability of the measurement device or the biomechanical signal. This study investigated the reliability of stride time and sacral acceleration variability measures calculated from inertial measurement units (IMUs).

Running Gait Complexity During an Overground, Mass-Participation Five-Kilometre Run.

Human locomotion contains innate variability which may provide health insights. Detrended fluctuation analysis (DFA) has been used to quantify the temporal structure of variability for treadmill running, although it has been less commonly applied to uncontrolled overground running. This study aimed to determine how running gait complexity changes in response to gradient and elapsed exercise duration during uncontrolled overground running.

The repeatability of stride time variability, regularity, and long-range correlations.

Background: Detrended fluctuation analysis (DFA) and sample entropy (SE) measure the long-term correlations and regularity of gait patterns, respectively, having previously been used to identify participants at risk of falling, previous history of injury, or patients with motor diseases. Since these measures are more sensitive to gait impairment than linear measures (e.g.

Pharmacological restriction of genomic binding sites redirects PU.1 pioneer transcription factor activity.

Transcription factor (TF) DNA-binding dynamics govern cell fate and identity. However, our ability to pharmacologically control TF localization is limited. Here we leverage chemically driven binding site restriction leading to robust and DNA-sequence-specific redistribution of PU.

Mechanomemory of pulmonary fibroblasts demonstrates reversibility of transcriptomics and contraction phenotypes.

Fibroblasts are cells responsible for producing extracellular matrix (ECM) components, which provides physical support for organs. Although these mesenchymal cells are responsive to mechanical cues in their environment, the permanence of these mechanophenotypes is not well defined. We investigated the mechanomemory of lung fibroblasts and determined how switching culture conditions modulate cell responses and function.

Central Nervous System Histoplasmosis After Acute COVID-19 in An Adolescent.

Central nervous system histoplasmosis is a serious complication of a common endemic mycosis, but it is rare in immunocompetent hosts. SARS-CoV-2 has introduced significant challenges into the healthcare setting with overlapping clinical presentations that may delay the diagnosis of alternative conditions. Additionally, it may lead to immune dysregulation and increase the risk for secondary infections, including invasive fungal diseases.

The effect of experience on the perception of affordances for aperture crossing in cycling.

To ride successfully and safely, cyclists must perceive and act on the affordances that are available in a given situation. This study investigated whether experience in perceiving and acting with respect to a person-plus-object system would influence whether and how a person choses to cross an aperture of different widths, especially in relation to their maximal action capabilities. We also explore whether the distribution of action modes reflects this effect.

The Agreement between Wearable Sensors and Force Plates for the Analysis of Stride Time Variability.

The variability and regularity of stride time may help identify individuals at a greater risk of injury during military load carriage. Wearable sensors could provide a cost-effective, portable solution for recording these measures, but establishing their validity is necessary. This study aimed to determine the agreement of several measures of stride time variability across five wearable sensors (Opal APDM, Vicon Blue Trident, Axivity, Plantiga, Xsens DOT) and force plates during military load carriage.

Bladder instillations vs onabotulinumtoxinA injection for interstitial cystitis/bladder pain syndrome: a randomized clinical trial.

Background: Interstitial cystitis (IC)/bladder pain syndrome (BPS) is an unpleasant sensation related to the bladder with lower urinary tract symptoms lasting more than 6 weeks, unrelated to an otherwise identifiable cause. The etiology is likely multifactorial including urothelial abnormalities, neurogenic pain upregulation, and potentially bladder and vaginal microbiome alterations. Despite treatment effectiveness of both bladder instillations and intradetrusor onabotulinumtoxinA injection for this condition, a head-to-head comparison has not been performed.

More With Less: Single-Incision Sling Insertion Techniques.

Study Objective: To demonstrate reproducible procedures for efficient single-incision sling insertion and troubleshooting.

Design: Narrated video footage with stepwise demonstration of single-incision sling insertion technique with anchor system.

Setting: The mesh midurethral sling is a highly effective and safe procedure that is considered the gold standard for surgical treatment of stress urinary incontinence.

Runners' responses to a biofeedback intervention aimed to reduce tibial acceleration differ within and between individuals.

An increment in peak tibial acceleration (PTA) may be related to an increased risk of running-rated injury. Many authors believe that reducing PTA through improved shock-absorption could, therefore, help prevent injury. The aim of the current study was, therefore, to investigate the individual responses of participants to a biofeedback intervention aimed at reducing PTA.

A systematic review of perception of affordances for the person-plus-object system.

Human behavior often involves the use of an object held by or attached to the body, which modifies the individual's action capabilities. Moreover, most everyday behaviors consist of sets of behaviors that are nested over multiple spatial and temporal scales, which require perceiving and acting on nested affordances for the person-plus-object system. This systematic review investigates how individuals attune to information about affordances involving the person-plus-object system and how they (re)calibrate their actions to relevant information.

Colpocleisis Techniques: An Open-and-shut Case for Advanced Pelvic Organ Prolapse.

Objective: To highlight several advanced surgical techniques for all types of colpocleisis. Pelvic organ prolapse is a common condition that affects up to 40% of the postmenopausal female population. Particularly for women with advanced pelvic organ prolapse who no longer desire penetrative vaginal intercourse and with multiple medical comorbidities, the obliterative approach is preferred due to decreased anesthetic needs, operative time, and perioperative morbidity.

Effects of using rigid tape with bandaging techniques on wrist joint motion during boxing shots in elite male athletes.

Objectives: To investigate the effects of bandaging techniques on wrist motion on impact during different shot types in elite male boxers.

Design: Repeated-measures study.

Setting: Field Experiment PARTICIPANTS: Two shot types, straight and bent arm, were assessed with 18 elite male boxers wearing either bandage only or bandage plus tape.

Pulmonary Histoplasmosis: A Clinical Update.

, the etiological agent for histoplasmosis, is a dimorphic fungus that grows as a mold in the environment and as a yeast in human tissues. The areas of highest endemicity lie within the Mississippi and Ohio River Valleys of North America and parts of Central and South America. The most common clinical presentations include pulmonary histoplasmosis, which can resemble community-acquired pneumonia, tuberculosis, sarcoidosis, or malignancy; however, certain patients can develop mediastinal involvement or progression to disseminated disease.

Alveolar macrophages drive lung fibroblast function in cocultures of IPF and normal patient samples.

Idiopathic pulmonary fibrosis (IPF) is characterized by increased collagen accumulation that is progressive and nonresolving. Although fibrosis progression may be regulated by fibroblasts and alveolar macrophage (AM) interactions, this cellular interplay has not been fully elucidated. To study AM-fibroblast interactions, cells were isolated from IPF and normal human lung tissue and cultured independently or together in direct 2-D coculture, direct 3-D coculture, indirect transwell, and in 3-D hydrogels.

The effect of external loads and biological sex on coupling variability during load carriage.

Background: Load carriage is a fundamental requirement for military personnel that commonly results in lower-limb injuries. Coupling variability represents a potential injury mechanism for such repetitive tasks and its unknown whether external loads and biological sex affect coupling variability during load carriage.

Research Question: Is there a sex-by-load interaction during load carriage at self-selected walking speeds?

Methods: Twenty-six participants (13 males, 13 females) completed three 10-minute treadmill-based trials wearing body-borne external load (0 %BM, 20 %BM, and 40 %BM) at load-specific self-selected walking speeds.

Green and Pleasant Lands: The Affective and Cerebral Hemodynamic Effects of Presence in Virtual Environments During Exercise.

Pleasant exercise experiences increase the likelihood of exercise adherence, and innovative strategies to promote consistently pleasant exercise experiences are needed. In this study we compared a novel nature-based virtual reality environment, a nature-based 360° video, and a control condition to test the hypothesis that greater presence in virtual space would promote positive affective experiences during exercise. Moreover, we assessed prefrontal cerebral hemodynamics using near infrared spectroscopy to explore possible neural underpinnings of dissociative strategies during exercise.

Can handling a weapon make soldiers more unstable?

Gait stability in soldiers can be affected by task constraints that may lead to injuries. This study determined the effects of weapon handling and speed on gait stability in seventeen soldiers walking on a treadmill with and without a replica weapon at self-selected (SS), 3.5 km·h, 5.

Safety of maintaining elective and emergency surgery during the COVID-19 pandemic with the introduction of a Protected Elective Surgical Unit (PESU): A cross-specialty evaluation of 30-day outcomes in 9,925 patients undergoing surgery in a University Health Board.

Background: The COVID-19 pandemic has caused unprecedented health care challenges mandating surgical service reconfiguration. Within our hospital, emergency and elective streams were separated and self-contained Protected Elective Surgical Units were developed to mitigate against infection-related morbidity. Aims of this study were to determine the risk of COVID-19 transmission and mortality and whether the development of Protected Elective Surgical Units can result in significant reduction in risk.

Quantifying the hip-ankle synergy in short-term maximal cycling.

Simulation studies have demonstrated that the hip and ankle joints form a task-specific synergy during the downstroke in maximal cycling to enable the power produced by the hip extensor muscles to be transferred to the crank. The existence of the hip-ankle synergy has not been investigated experimentally. Therefore, we sought to apply a modified vector coding technique to quantify the strength of the hip-ankle moment synergy in the downstroke during short-term maximal cycling at a pedalling rate of 135 rpm.

Orthotic shorts for improving gait and walking in multiple sclerosis: a feasibility study.

Purpose: To explore the acceptability and potential efficacy of orthotic shorts in people with multiple sclerosis.

Materials And Methods: This mixed-methods, cross-over study utilised qualitative data to investigate acceptability, including perceived effectiveness. Quantitative data included wear times, self-selected walking speed, spatiotemporal gait parameters, and participant-perceived walking ability.

Coordination variability reveals the features of the 'independent seat' in competitive dressage riders.

The rider's ability to consistently coordinate their movements to their horse is a key determinant of performance in equestrian sport. This study investigated the inter-segmental coordination variability between the vertical displacement of a riding simulator and the pitch rotation of 28 competitive female dressage riders' head, trunk, pelvis, and left foot, in simulated medium and extended trot. A statistical non-parametric mapping three-way repeated-measures ANOVA investigated the influence of gait, competition level and segment on coordination variability.

Effects of strength training on the biomechanics and coordination of short-term maximal cycling.

The aim was to investigate the effects of a gym-based strength training intervention on biomechanics and intermuscular coordination patterns during short-term maximal cycling. Twelve track sprint cyclists performed 3 × 4 s seated sprints at 135 rpm, interspersed with 2 × 4 s seated sprints at 60 rpm on an isokinetic ergometer, repeating the session 11.6 ± 1.