Measurement and Analysis of In Vivo Gastroduodenal Slow Wave Patterns Using Anatomically-Specific Cradles and Electrodes.

Objective: Bioelectrical 'slow waves' regulate gastrointestinal contractions. We aimed to confirm whether the pyloric sphincter demarcates slow waves in the intact stomach and duodenum.

Methods: We developed and validated novel anatomically-specific electrode cradles and analysis techniques which enable high-resolution slow wave mapping across the in vivo gastroduodenal junction.

Anatomically-Specific, 3D-Printed Cradles Enable In Vivo Mapping of the Bioelectrical Activation across the Gastroduodenal Junction.

Rhythmic bioelectrical 'slow waves' are a key regulatory mechanism underpinning digestion. The pyloric sphincter separates the independent slow wave and contractile behavior of the stomach and small intestine, while also regulating gastric emptying. In this study, we develop and validate anatomically-specific electrode cradles and analysis techniques in pigs, to map in vivo slow wave activation across this critical pylorus region for the first time.

Transmural Temperature Monitoring to Quantify Thermal Conduction And Lesion Formation During Gastric Ablation, an Emerging Therapy for Gastric Dysrhythmias.

Gastric ablation is emerging as a potential therapy for electrical dysrhythmias associated with gastric disorders. Thermal conduction properties of gastric tissue during ablation have not yet been defined, but are necessary for optimizing the technique and translating ablation to clinical therapy. We developed custom needle-based transmural temperature probes to quantify the temperature of gastric tissue during ablation.