Publications by authors named "Whang E"

Objective: Concerns exist about clinical and operative skill decay in surgery residents when they dedicate time away from clinical training to pursue research. However, it remains undetermined how to best prevent these negative impacts. Our study evaluated the perspectives of surgical research residents on interventions to improve their reentry into clinical training.

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  • * The study reveals that hepatocytes are the main producers of lipopolysaccharide binding protein (LBP), which is implicated in liver inflammation but does not significantly affect liver fibrosis.
  • * Research indicates that targeting inflammation through LBP might not effectively reduce liver fibrosis, challenging the current strategies aimed at managing MAFLD.
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  • The study investigates how Aster-A, a cholesterol transporter, affects membrane cholesterol levels in T cells and their immune function.
  • Aster-A is recruited to the plasma membrane during T cell activation, facilitating the removal of excess cholesterol, which is crucial for proper T cell receptor signaling and function.
  • Without Aster-A, T cells accumulate excess cholesterol, leading to enhanced immune responses and changes in nutrient absorption, contributing to resistance against obesity.
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Intestinal absorption is an important contributor to systemic cholesterol homeostasis. Niemann-Pick C1 Like 1 (NPC1L1) assists in the initial step of dietary cholesterol uptake, but how cholesterol moves downstream of NPC1L1 is unknown. We show that Aster-B and Aster-C are critical for nonvesicular cholesterol movement in enterocytes.

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  • Cholesterol absorption in the intestine is influenced by Niemann-Pick C1 Like 1 (NPC1L1), the target of the drug ezetimibe, but how cholesterol moves after NPC1L1 is not well understood.
  • Aster-B and Aster-C proteins are essential for cholesterol transport in enterocytes, connecting NPC1L1 at the cell membrane and ACAT2 in the endoplasmic reticulum.
  • Mice missing Aster proteins have reduced cholesterol absorption and are less likely to develop high cholesterol from their diet, indicating that the Aster pathway is a potential target for treating cholesterol-related issues.
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Introduction: There are increasing concerns regarding resident autonomy in the context of efficiency, legal ramifications, patient expectations and patient safety. However, autonomy is necessary to develop competent, independent surgeons. Therefore, educational paradigms that maximize opportunities for entrustability without sacrificing patient safety are necessary to ensure adequate training for surgeons.

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  • Changes in accessible plasma membrane cholesterol are linked to the Aster family's role in regulating cholesterol synthesis and metabolism in cell models, but their impact on living organisms was previously unclear.
  • The study identifies two key situations in the liver—fasting and reverse cholesterol transport—where accessible PM cholesterol is generated and the Aster pathway is activated, highlighting the importance of these mechanisms.
  • Aster-dependent cholesterol transport during fasting enhances cholesterol movement in the body, and loss of Asters leads to increased plasma cholesterol and accumulation in peripheral tissues, affecting overall lipid balance.
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Background: Our study evaluated general surgery resident indebtedness and perspectives on financial compensation.

Methods: In May 2020, a survey was distributed nationwide by general surgery program directors in the Association of Program Directors in Surgery on a voluntary basis to their residents.

Results: The survey was completed by 419 general surgery residents.

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Background: Disparities based on socioeconomic factors such as race, ethnicity, marital status, and insurance status are associated with pancreatic cancer resection, but these disparities are usually not observed for survival after resection. It is unknown if there are disparities when patients undergo their treatment in a non-fee-for-service, equal-access healthcare system such as the Veterans Health Administration (VHA).

Methods: Patients having T1-T3 M0 pancreatic adenocarcinoma diagnosed between 2006 and 2017 were identified from the VHA Corporate Data Warehouse.

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Background: Recurrent laryngeal nerve (RLN) injury is a significant complication after thyroidectomy. Understanding risk factors for RLN injury and the associated postoperative complications may help inform quality improvement initiatives.

Methods: The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) thyroidectomy-targeted database was utilized for patients undergoing total thyroidectomy between 2016 and 2017.

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Background: Several studies have identified disparities in pancreatic cancer treatment associated with gender, race, and ethnicity. There are limited data examining disparities in short-term adverse outcomes after pancreatic resection for cancer. The aim of this study is to evaluate associations of gender, race, and ethnicity with morbidity and mortality after pancreatic resection for malignancy.

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Background/objectives: Rejection and infectious enteritis in intestinal transplant (ITx) patients present with virtually identical symptoms. Currently, the gold standard for differentiating between these two conditions is endoscopy, which is invasive and costly. Our primary aim was to identify differences in peripheral blood cytokines during episodes of acute cellular rejection (ACR) and infectious enteritis in patients with intestinal transplants.

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Given the importance of operative documentation, we reviewed operative notes for surgeries that required splenic flexure mobilization (SFM) to determine their accuracy. We performed a retrospective review of 51 operative notes for complete SFMs performed at a single institution from January 2015 to June 2020. None of the operative notes reported a rationale for performing SFM, use of preoperative imaging to guide technical approach, reasoning for the operative method and mobilization approach used, or specific steps taken to ensure that SFM was done safely.

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The face mask has been used to protect against airborne diseases throughout history. We conducted a historical review of the literature on the origin of the face mask, the scientific evidence of its benefits, and its implications for domestic and international politics. We performed a comprehensive search for peer- and nonpeer- reviewed literature published between 1905 and 2020.

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