Topical treatment for postinflammatory hyperpigmentation: a systematic review.

Background: Topical measures are the mainstay treatment for postinflammatory hyperpigmentation (PIH). Numerous studies have assessed the efficacy of topical medications for the treatment of PIH, but few have evaluated the quality of evidence supporting these topical therapies. We performed a systematic review to evaluate the evidence of topical treatments for PIH.

Drug-Induced Intracranial Hypertension: A Systematic Review and Critical Assessment of Drug-Induced Causes.

Background: Idiopathic intracranial hypertension (IIH) is a condition with increased intracranial pressure of unknown etiology. Its presenting symptoms include persistent headache, pulsatile tinnitus, and visual obscuration. It tends to occur in obese women of childbearing age, and its greatest risk is irreversible loss of vision.

Drug-induced phototoxicity: A systematic review.

Background: Phototoxicity has been attributed to numerous oral drugs over the past 60 years.

Objective: Determine the quality of evidence supporting suspected phototoxicity from oral drugs.

Methods: The MEDLINE and EMBASE databases were searched for all studies that contain original data for drug-induced phototoxicity and were published between May 1959 and December 2016.

Diagnosis and management of psoriasis.

Objective: To provide primary care clinicians with an up-to-date and practical overview of the diagnosis and management of psoriasis.

Quality Of Evidence: PubMed, MEDLINE, EMBASE, and Cochrane databases were searched for relevant meta-analyses, randomized controlled trials, systematic reviews, and observational studies about the diagnosis and management of psoriasis.

Main Message: Psoriasis is a chronic, multisystem inflammatory disease with predominantly skin and joint involvement.

Survival rates of biological therapies for psoriasis treatment in real-world clinical practice: A Canadian multicentre retrospective study.

Background/objectives: Data on biologic drug survival in real-world psoriasis treatment are limited. There is a need to evaluate long-term trends of biologic use outside the realm of clinical trials.

Methods: A multicentre chart review was conducted with patients' data from September 2005 to September 2014.

Risk of Malignancy in Dermatomyositis and Polymyositis.

Background: There is variation in the risk of malignancy in dermatomyositis (DM) and polymyositis (PM) in the existing literature.

Objective: To conduct a meta-analysis to estimate the risk of malignancy in DM and PM as compared with the general population.

Methods: Medline and Embase Database abstracts were searched through August 2014 using the search terms myositis, neoplasms, and paraneoplastic syndromes.

MACEs Not Associated With the Use of Biologic Therapy for Psoriasis in Real-World Clinical Practice: A Canadian Multicenter Retrospective Study.

Introduction: Previous reports have shown inconsistent findings with regard to the relationship between biologic therapy and risk for major adverse cardiovascular events (MACEs).

Objectives: The aim of this study was to determine the overall rate of MACEs in a cohort of 398 patients.

Methods: All patients treated with biologics for psoriasis at 2 academic centers in Toronto, Ontario, between September 2005 and September 2014 were considered for inclusion.

Validating the diagnostic code for acne in a tertiary care dermatology centre.

Background: Administrative databases provide valuable patient data and are used to conduct population-based studies. However, no studies have been conducted to validate the codes for dermatological conditions.

Objective: To evaluate the validity of ICD 9 code 706 for acne.

Lupus Miliaris Disseminatus Faciei With Isolated Axillary Involvement.

Background: Lupus miliaris disseminatus faciei (LMDF) is a chronic, granulomatous inflammatory disorder, commonly localized to the face.

Objective: To present an unusual manifestation of LMDF and review the literature.

Methods: We document a 41-year-old woman with LMDF with isolated axillary involvement.

Clinical Features and Patient Outcomes of Hidradenitis Suppurativa: A Cross-Sectional Retrospective Study.

Background: Despite the high burden of disease associated with hidradenitis suppurativa (HS), epidemiologic data are scarce.

Objective: The objective was to review demographic features and clinical findings in 80 HS patients from 2 referral centres in Ontario, Canada, from October 2013 to September 2014, and to assess for factors that are associated with more advanced disease.

Methods: Multicentre cross-sectional study.

Adverse events resulting in withdrawal of biologic therapy for psoriasis in real-world clinical practice: A Canadian multicenter retrospective study.

Background: Safety profiles of biologics for treatment of psoriasis are limited to data from randomized controlled trials. There is a need for comparative safety reports of biologics based on data from clinical practice.

Objective: We sought to estimate and compare the incidence of adverse events (AEs) leading to withdrawal of biologics (etanercept, infliximab, adalimumab, and ustekinumab) in the treatment of psoriasis.

Public Engagement with Dermatology Contents on Facebook.

Background: The gtring presence of dermatology platforms on Facebook has been acknowledged; however, little is known about the extent to which different types of content influence the level of engagement with online users.

Objective: To assess the level of public engagement with different types of content posted on Facebook pages devoted to dermatology.

Methods: A search on Facebook identified existing pages for dermatology academic journals, professional societies, and patient-centered groups.

Skin Necrosis from Intra-articular Hyaluronic Acid Injection.

Background: Tissue necrosis is a rare yet potentially serious complication of intra-articular (IA) hyaluronic acid (HA) injections for treatment of knee osteoarthritis.

Objective: To report a case of a patient with cutaneous necrosis after IA HA injection for treatment of knee osteoarthritis, presenting as a livedoid violaceous patch on the right knee.

Method: We report a case of cutaneous necrosis as a rare complication of IA HA injection for treatment of knee osteoarthritis.

Epidermolysis Bullosa Pruriginosa: Case Series and Review of the Literature.

Epidermolysis bullosa (EB) pruriginosa is a rare clinical subtype of dystrophic epidermolysis bullosa (DEB) that is characterized by intense pruritus resulting in hypertrophic, lichenified, prurigo-like plaques and nodules secondary to scratching. The variability in the age of onset, rarity of intact bullae, histologic ambiguities, and close resemblance to other conditions such as acquired inflammatory dermatoses may make diagnosis difficult for this unusual condition, for which fewer than 100 cases have been documented. In this report, we describe 3 cases of EB pruriginosa and review the current literature.

Epidermolysis bullosa pruriginosa: a systematic review exploring genotype-phenotype correlation.

Introduction: Epidermolysis bullosa pruriginosa (EBP) is a clinical variant of dystrophic epidermolysis bullosa (DEB), characterized by intense pruritus and hypertrophic, lichenified, prurigo-like papules, plaques, and nodules secondary to scratching. These clinical findings have been attributed to various mutations in the COL7A1 gene. Previous reports have yielded inconsistent findings regarding a possible genotype-phenotype relationship in EBP.

Quality-of-life impairment in patients with hidradenitis suppurativa: a Canadian study.

Background: Hidradenitis suppurativa (HS) is a chronic relapsing condition with a clinical picture that includes solitary nodules; diffuse, painful abscesses; malodorous drainage; sinus tract formation; and scarring. Treatment options are often unsatisfactory. The adverse effects of this disease on quality of life (QoL) is not extensively studied, especially in the Canadian population.

Use of facebook as a tool for knowledge dissemination in dermatology.

Background: The presence of dermatology-related platforms in social media has been acknowledged; however, the level of engagement of the public with these platforms has not been evaluated.

Objective: To use the Engagement Rate to assess the level of engagement of the public with Facebook pages devoted to dermatology.

Methods: A search on Facebook identified Facebook pages for dermatology academic journals, professional societies, and patient-centered groups with the highest number of Facebook likes.

Pretibial Myxedema: Case Presentation and Review of Treatment Options.

Pretibial myxedema (PM) is a rare autoimmune manifestation of Graves' disease, which commonly presents as diffuse, nonpitting edema of shins and less often as plaques, nodules, or elephantiasis lesions mimicking lymphedema. We present a 57-year-old woman with 12-month history of PM, which occurred a year after treatment of Graves' disease and improved with topical corticosteroids, support stockings, and intralesional steroid injections until recurrence with local erythema and woody edema. A literature review was undertaken of the evidence-based treatment modalities for symptomatic PM: although commonly asymptomatic and self-limited, severe cases of PM may be treated with topical corticosteroid, compressive therapy, and intralesional corticosteroid injections.

The impact of esophageal reflux-induced symptoms on quality of life after gastrectomy in patients with gastric cancer.

Purpose: To evaluate the prevalence of esophageal reflux-induced symptoms after gastrectomy owing to gastric cancer and assess the relationship between esophageal reflux-induced symptoms and quality of life.

Materials And Methods: From January 2012 to May 2012, 332 patients were enrolled in this cross-sectional study. The patients had a history of curative resection for gastric cancer at least 6 months previously without recurrence, other malignancy, or ongoing chemotherapy.