Redecoration of apartments promotes obstructive bronchitis in atopy risk infants--results of the LARS Study.

Findings by other authors indicate that exposure to chemical emissions from indoor paint is related to asthma symptoms in adults. In their first years of life children are receptive to obstructive airway diseases. The aim of this study was to investigate the influence of redecoration of the apartment on airway symptoms in infants during the first two years of life.

Increased incidence of allergic sensitisation and respiratory diseases due to mould exposure: results of the Leipzig Allergy Risk children Study (LARS).

To investigate mould effects on health, the concentration of mould spores in air and dust was determined during a prospective cohort study. Clinical outcome was estimated by questionnaires and determination of specific IgE antibodies and intracellular cytokine production of T cells. A significant association was observed between the incidence of respiratory tract infections and exposure to Penicillium spores.

Enhanced in vivo IgE production and T cell polarization toward the type 2 phenotype in association with indoor exposure to VOC: results of the LARS study.

The association between indoor exposure to volatile organic compounds (VOC), prevalence of allergic sensitization and cytokine secretion profile of peripheral T cells was studied in 3 year old children of the LARS study (Leipzig Allergy Risk Children Study) to investigate the role of VOC exposure as a risk factor for the development of atopic disease. Indoor VOC exposure was measured over a period of 4 weeks in infants' bedrooms using a passive sampling system. Specific IgE antibodies to food, indoor and outdoor allergens were measured by the Pharmacia CAP system and correlated to VOC exposure (n = 120).

Effects of indoor painting and smoking on airway symptoms in atopy risk children in the first year of life results of the LARS-study. Leipzig Allergy High-Risk Children Study.

Introduction: The Leipzig Allergy High-Risk Children Study (LARS) is a prospective nested cohort control study about the influence of chemical indoor exposure in dwellings on the health outcome of atopy-risk children during the first years of life.

Design And Methods: 475 premature children and children with allergic risk factors have been selected out of the 1995/1996 birth cohort in the city of Leipzig. Twenty-five volatile organic compounds (VOC) were measured in the infant's bedrooms using passive sampling systems for 4 weeks after birth.

Associations between duration of breast-feeding, sensitization to hens' eggs and eczema infantum in one and two year old children at high risk of atopy.

Unlabelled: Through a cohort study, factors for the development of atopic disorders among children at high-risk of atopy were investigated by means of anamnesis, lifestyle factors and laboratory parameters. 475 high-risk children were selected out of the whole population of infants born within one year in the City and District of Leipzig. These 475 had an increased cord blood IgE (> 0.

[Iatrogenic Cushing syndrome and mutatio tarda caused by dexamethasone containing nose drops].

Nasal steroid drops can produce iatrogenic Cushing's syndrome if the recommended dose is exceeded. We now report a 19-year-old male patient for whom dexamethasone nasal drops were prescribed because of nasal obstruction. He had been using these drops for more than 5 years, with a daily dexamethasone dose of 0.

Toxicity screening of liposomes.

Phospholipids are the major components of most liposomes. Extensive testing of these naturally occurring compounds has revealed them to be remarkably safe for pharmaceutical use. Addition of other constituents to liposomes in order to alter stability or kinetics can result in an increase in toxic potential, particularly on parenteral administration of liposomes.

[Experiences with the use of an intravascular 6 French endosonography catheter in vivo].

Further progress in intraluminal sonography has led to the development of a 6 French ultrasound imaging catheter. This report demonstrates in vivo results using this new technique in a swine. Intraluminal echographic images obtained from the aorta and iliac arteries were of good quality.

[Liver glycogen of the Wistar rat in experimental chronic cadmium intoxication under seasonal conditions].

Male Wistar-rats were used to investigate the liver glycogen pattern quantitatively under normal conditions and after oral application of CdCl2 (dosage: 50 ppm or 150 ppm) solved in drinking-water. The duration of the experiment was 1,3,6, or 12 month. The control animals have the lowest liver glycogen content at the beginning of the spring.

[Heavy metal pattern in the liver of Wistar rats in experimental chronic cadmium poisoning].

Male young and adult Wistar-rats were used to investigate the heavy metal pattern of the liver after application of CdCl2 (dosage: 50 ppm or 150 ppm) solved in the drinking-water. The duration of the experiment was 1, 3, 6, or 12 month. Under these conditions, an increasing accumulation of heavy metal storages in the liver was obtained.