Trajectories of episodic memory in midlife: Historical change from a cross-country perspective.

According to the Flynn effect, performance on cognitive ability tests has improved over the past decades. However, we know very little about whether such historical improvements generalize to middle-aged adults (aged 45-65) and differ across nations. We used harmonized data on episodic memory from nationally representative longitudinal panel surveys across a total of 16 countries (United States, Mexico, China, England, and countries in Continental, Mediterranean, and Nordic Europe).

Can the free/total psa ratio predict undetected intraductal carcinoma and cribriform pattern at biopsy?

Background: Intraductal carcinoma (IDC) and cribriform pattern (Crib) of prostate cancer are recognised as independent prognosticators of poor outcome, both in prostate biopsies and radical prostatectomy (RP) specimens.

Objective: This study aimed to determine the predictive value of Free-to-total PSA ratio (FPSAR) in identifying missed IDC/Crib at the time of biopsy as compared to the final surgical specimen.

Materials And Methods: Patients who underwent RP between January 2015 and December 2022 were included in the study.

Undetected Cribriform and Intraductal Prostate Cancer at biopsy is associated with adverse outcomes.

Background: Intraductal carcinoma (IDC) and cribriform pattern (Crib) of prostate cancer are increasingly recognized as independent prognosticators of poor outcome, both in prostate biopsies and radical prostatectomy (RP) specimens.

Objective: The aim of our project is to assess the impact of false negative biopsies for these two characteristics on oncological outcomes.

Material And Methods: Patients who underwent RP between January 2015 and December 2022 were included in the study.

Association of Free-to-Total PSA Ratio and F-DCFPyL Prostate-Specific Membrane Antigen PET/CT Findings in Patients with Biochemical Recurrence After Radical Prostatectomy: A Prospective Single-Center Study.

In Canada and across the globe, access to PSMA PET/CT is limited and expensive. For patients with biochemical recurrence (BCR) after treatment for prostate cancer, novel strategies are needed to better stratify patients who may or may not benefit from a PSMA PET scan. The role of the free-to-total prostate-specific antigen (PSA) ratio (FPSAR) in posttreatment prostate cancer, specifically in the PSMA PET/CT era, remains unknown.

Follow-up strategies after trimodal treatment for muscle-invasive bladder cancer: a systematic review.

Purpose: Optimal follow-up strategies following trimodal treatment for muscle invasive bladder cancer play a crucial role in detecting and managing relapse and side-effects. This article provides a comprehensive summary of the patterns and risk factors of relapse, functional outcomes, and follow-up protocols.

Methods: A systematic literature search on PubMed and review of current guidelines and institutional follow-up protocols after trimodal therapy were conducted.

Cut-offs for relapse detection in men with stage I testicular germ cell tumors during active surveillance within a prospective multicentre cohort study using either raw or housekeeper normalized miR-371a-3p serum levels.

Purpose: MiR-371a-3p represents a novel liquid biomarker that detects all histologies of germ-cell tumors (GCT) except teratoma. However, it is currently unclear whether miR-371a-3p results obtained directly from RT-PCR (raw Cq) or normalized for housekeeper genes and transformed into the relative quantity (RQ) value should be used and at what cut-off level. The purpose of this research was to evaluate, which values should be used, and a potential cut-off level for relapse-detection to inform subsequent studies.

Longitudinal associations between time perspective and life satisfaction across adulthood.

Time perspective is an important predictor of well-being. How time is represented, is itself subject to developmental change. A time perspective dominated by the future is increasingly replaced by one focused on the present and past as remaining lifetime decreases.

Adjuvant immune checkpoint inhibitors for urothelial carcinoma: systematic review and Meta-analysis.

Purpose: To compare disease-free survival (DFS), overall survival (OS), and adverse events (AEs) among muscle-invasive urothelial carcinoma (MIUC) patients receiving adjuvant immune checkpoint inhibitors (ICIs) versus placebo/observation following radical surgery.

Methods: This was a systematic review/meta-analysis of all published phase 3 randomized controlled trials. MEDLINE, EMBASE, and Cochrane were searched from inception until April 4, 2024.

Feeling older, feeling pain? Reciprocal between-person and within-person associations of pain and subjective age in the second half of life.

Experiencing pain in middle adulthood and old age might be interpreted as a sign of aging and make people feel older, whereas feeling older has behavioral, motivational, and physiological consequences that might increase the risk of pain. We investigated between-person and within-person associations between pain, subjective age, and chronological age in middle-aged and older adults. Data from the German Ageing Survey were used ( = 13,874 who provided more than 32,000 observations, baseline mean age = 62.

Successful Aging and Subjective Aging: Toward a Framework to Research a Neglected Connection.

Research related to subjective aging, which describes how individuals perceive, interpret and evaluate their own aging, has substantially grown in the past two decades. Evidence from longitudinal studies shows that subjective aging predicts health, quality of life, and functioning in later life. However, the existing literature on successful aging has mostly neglected the role of subjective aging.

Postponing old age: Evidence for historical change toward a later perceived onset of old age.

"At what age would you describe someone as old?" Perceptions of when old age begins might be prone to upward shifts because of historical increases in life expectancy and in retirement age, as well as because of better psychosocial functioning in later life. We investigated historical changes in within-person trajectories of the perceived onset of old age using data from 14,056 participants who entered the German Ageing Survey at age 40-85 years and who completed up to eight assessments across 25 years. Using longitudinal multilevel regression models, we found that at age 64, the average perceived onset of old age is at about age 75 years.

BioPrev-C - development and validation of a contemporary prostate cancer risk calculator.

Objectives: To develop a novel biopsy prostate cancer (PCa) prevention calculator (BioPrev-C) using data from a prospective cohort all undergoing mpMRI targeted and transperineal template saturation biopsy.

Materials And Methods: Data of all men who underwent prostate biopsy in our academic tertiary care center between 11/2016 and 10/2019 was prospectively collected. We developed a clinical prediction model for the detection of high-grade PCa (Gleason score ≥7) based on a multivariable logistic regression model incorporating age, PSA, prostate volume, digital rectal examination, family history, previous negative biopsy, 5-alpha-reductase inhibitor use and MRI PI-RADS score.

Do Swiss urologists and Swiss internists screen themselves and their relatives for prostate cancer? A questionnaire study.

Purpose: Prostate-specific antigen (PSA) screening for men at risk of prostate cancer is controversial. The current recommendation is to raise awareness of prostate cancer and offer PSA screening in accordance with shared decision- making. Whether the possibility of a PSA screen is discussed with the patient depends on the treating physician, but data on physicians' attitudes towards PSA screening are scarce.

Prognostic value of pretreatment inflammatory markers in localised prostate cancer before radical prostatectomy.

Purpose: There is growing evidence of an association between inflammatory processes and cancer development and progression. In different solid tumor entities, a pronounced inflammatory response is associated with worse oncological outcome. In this study, we aim to evaluate the prognostic role of clinically established pretreatment inflammatory markers in patients with localised prostate cancer (PCa) before radical prostatectomy (RP).

What happens to endoscopic/arthroscopic tenotomies with iliopsoas impingement in the medium term? Review of a prospective cohort of 64 patients with a minimum follow-up of 5 years.

Introduction: The occurrence of iliopsoas impingement (IPI) after total hip arthroplasty (THA) is a proven risk factor for negative outcomes. Endoscopic or arthroscopic tenotomies of the iliopsoas offer a surgical solution with short-term results that have already been validated in prospective multicenter series. We carried out a review of the patients at more than 5 years of follow-up in order to assess the stability of the results over time.

Between-person and within-person associations among sensory functioning and attitude toward own aging in old age: Evidence for mutual relations.

Late-life hearing loss and vision loss might prompt more negative attitudes toward one's own aging because older adults may interpret impaired sensory functioning as a sign of aging. At the same time, more positive attitudes toward own aging might, via various mechanisms, be associated with better sensory functioning. We investigated how objective hearing and vision are associated with attitude toward own aging (ATOA) over time.

Prospective randomized controlled trial comparing a novel and dedicated device with conventional endoscopic techniques for the treatment of buried bumper syndrome (with video).

Background And Aims: Buried bumper syndrome (BBS) is a rare adverse event of PEG tubes. This study compared the newly developed Flamingo device (Fujifilm Medwork GmbH, Höchstadt, Germany) with conventional endoscopic techniques for BBS treatment.

Methods: This prospective, randomized controlled trial compared the Flamingo set (study group) with other endoscopic techniques (control group) for BBS treatment in 6 German hospitals.

Limited Value of Bladder Wash Cytology During Follow-Up of Patients With Non-muscle Invasive Bladder Cancer.

Aims We aimed to assess the performance of bladder wash cytology (BWC) in daily clinical practice in a pure follow-up cohort of patients previously diagnosed with non-muscle invasive bladder cancer (NMIBC). Materials and methods We analyzed 2064 BWCs derived from 314 patients followed for NMIBC (2003-2016). Follow-up investigations were performed using cystoscopy (CS) in combination with BWC.

Middle-aged and older adults' psychosocial functioning trajectories before and during the COVID-19 pandemic: Evidence for multidirectional trends.

So far little is known with regard to the impact of the COVID-19 pandemic on changes in psychosocial functioning of middle-aged and older adults across multiple indicators, interindividual differences in these changes, as well as the extent to which pandemic-related changes are temporary or not. We investigate different domains of psychosocial functioning (views on aging: attitude toward own aging [ATOA] and subjective age; subjective well-being: life satisfaction and depressive symptoms; health: self-rated health) across up to 7 years (prepandemic measurement occasions: 2014 and 2017; peri-pandemic measurement occasions: Summer 2020 and Winter 2020/2021) among middle-aged and older adults ( = 10,856; in 2014 = 64.3 years, = 11.

Younger Than Ever? Subjective Age Is Becoming Younger and Remains More Stable in Middle-Age and Older Adults Today.

Little is known about historical shifts in subjective age (i.e., how old individuals feel).

Self-reported hearing and awareness of age-related change : A domain-specific perspective.

Background: Impaired hearing is associated with disadvantages in developmental outcomes, such as compromised everyday social communication or reduced well-being. Hearing impairment might also have an impact on how individuals evaluate their own aging as deterioration in hearing can be interpreted as being age-related and as a phenomenon individuals attribute to getting older.

Objective: This study investigated how self-reported hearing is related to awareness of age-related change (AARC).