Publications by authors named "Weston C DeLomba"
This study investigated the tolerability and preliminary efficacy of duloxetine as an alternative nonopioid therapeutic option for the prevention of persistent musculoskeletal pain (MSP) among adults presenting to the emergency department with acute MSP after trauma or injury. In this randomized, double-blind, placebo-controlled study, eligible participants (n = 78) were randomized to 2 weeks of a daily dose of one of the following: placebo (n = 27), 30 mg duloxetine (n = 24), or 60 mg duloxetine (n = 27). Tolerability, the primary outcome, was measured by dropout rate and adverse effects.
View Article and Find Full Text PDFArticle Synopsis
- This study presents a simple method for creating -disubstituted cyclooctanoids, which are important in various biologically active compounds.
- It involves using substituted 1-alkenyl-5-pentyn-1-ols with specific -dialkyl groups at certain positions to produce cyclooct-4-enone derivatives through a microwave-assisted reaction.
- The research highlights that the presence of -dialkyl groups is crucial for the reaction to work, and it also examines how to adapt the method for more complex carbocycles using a -dialkoxy system.