The nursing shortage revisioning the future.

A severe shortage of nurses is being experienced nationally and globally. In South Florida, one of the most severely impacted regions in the world, a group of healthcare organizations, educational institutions, and nursing organizations formed the Nursing Shortage Consortium to combat the nursing shortage. Strategic efforts to recruit and retain nurses are underway, with a focus on nurturing interest among young people and increasing opportunities to stimulate their interest, to increase the supply of appropriately prepared professional nurses.

Shared resources: joint hospital sponsorship of continuing education.

Two competitive hospitals have successfully shared resources to present an annual interdisciplinary pharmacology symposium for the past 10 years. Hospitals can contain costs and create synergy by collaboration and shared resources.

Inability of polyethylene-glycol substituted copper- and zinc-containing superoxide dismutase to protect mice against radiation lethality.

The superoxide radical has been implicated in the mediation of radiation damage and CuZn superoxide dismutase, given to mice immediately before or after irradiation has, in several studies, reduced radiation lethality. CuZn superoxide dismutase has a very short plasma half-life, but if the enzyme is substituted with polyethylene-glycol a markedly increased circulation time can be achieved. In the present study an 80-fold increase in plasma superoxide dismutase activity was brought about in CBA mice by intraperitoneal injection of 7.

Radiation resistance and the CuZn superoxide dismutase, Mn superoxide dismutase, catalase, and glutathione peroxidase activities of seven human cell lines.

CuZn superoxide dismutase, Mn superoxide dismutase, catalase, and glutathione peroxidase form the primary enzymic defense against toxic oxygen reduction metabolites in cells. To test the importance of these protective enzymes in the cellular radiation response, the enzymic activities of seven different human cell lines were determined in parallel with their clonogenic survival characteristics. A positive correlation between the content of glutathione peroxidase in cell lines and their extrapolation numbers (n) and quasithreshold doses (Dq) was detected.

Copper- and zinc-containing superoxide dismutase, manganese-containing superoxide dismutase, catalase, and glutathione peroxidase in normal and neoplastic human cell lines and normal human tissues.

Copper- and zinc-containing superoxide dismutase, manganese-containing superoxide dismutase, catalase, and glutathione peroxidase form the primary enzymic defense against toxic oxygen reduction metabolites. Such metabolites have been implicated in the damage brought about by ionizing radiation, as well as in the effects of several cytostatic compounds. These enzymes were analyzed in 31 different human normal diploid and neoplastic cell lines and for comparison in 15 normal human tissues.

Copper- and zinc-containing superoxide dismutase and manganese-containing superoxide dismutase in human tissues and human malignant tumors.

Superoxide dismutases might conceivably protect against both ionizing radiation and free radical-producing antibiotic antitumor drugs. Copper- and zinc-containing superoxide dismutase (CuZn superoxide dismutase) and manganese-containing superoxide dismutase (Mn superoxide dismutase) were specifically assayed in human malignant tumors and for comparison in human tissues. The tumors possessed less CuZn superoxide dismutase than did the more metabolically active tissues, but there was a large overlap between the tissue and the tumor levels.