Preservation of left ventricular function in mitral valve surgery.

Surgery for degenerative mitral regurgitation has become complex. Preservation of annulo-ventricular continuity through the chordae tendineae is an important determinant of operative survival, postoperative left ventricular function, long-term survival, and quality of life. Some cardiologists believe that NYHA I function is never achieved after conventional mitral replacement with chordal transection.

Management of coexisting coarctation of the aorta and oesophageal atresia.

The combination of neonatal coarctation of the aorta (CoA) and oesophageal atresia (oA) is rare and the optimum approach to surgical correction uncertain. Of 84 consecutive neonates with CoA over an 8-year period, 2 had coexisting oA. We consider that CoA repair by subclavian flap should be performed first to improve the environment for healing of the oesophageal anastomosis.

Valve replacement with the ATS open pivot bileaflet prosthesis.

Objective: We sought to evaluate the ATS open pivot bileaflet valve with respect to haemodynamics and thromboembolism.

Methods: We prospectively studied 200 consecutive patients aged 13-80 years. One hundred and nineteen aortic, 103 mitral and 11 tricuspid valves were replaced in 172 single, 23 double and 5 triple valve procedures.

Fate of the native aorta after repair of acute type A dissection: a magnetic resonance imaging study.

Objective: To determine late patency of the aortic false lumen and propensity for aneurysm formation after repair of type A dissection.

Design: Retrospective follow up study.

Setting: Regional cardiac surgical unit.

Serum S100 protein: a potential marker for cerebral events during cardiopulmonary bypass.

Background: There is no simple method to determine the incidence or severity of brain injury after a cardiac operation. A serum marker equivalent to cardiac enzymes is required. S100 protein leaks from the cerebrospinal fluid to blood after cerebral injury.

Time-related hemodynamic changes after aortic replacement with the freestyle stentless xenograft.

Background: The Freestyle valve is a porcine aortic root fixed with net zero pressure across the cusps and treated with the anticalcification agent alpha-aminooleic acid. We evaluated the hemodynamic function of this stentless valve.

Methods: We implanted the valve into 80 consecutive patients scheduled to receive a bioprosthesis.

Posttraumatic coronary artery aneurysm.

A 31-year-old man sustained blunt deceleration trauma with dissection of the left anterior descending coronary artery. We repaired a posttraumatic coronary aneurysm to prevent late occlusion of the recanalized vessel. An internal mammary artery graft was applied as a precaution against postoperative thrombosis.

Management of aortic dissection.

Patients with aortic dissection are divided into two main groups: those with hypertension and those with syndromes involving hereditary defects of the aortic wall. The common finding in the setting of both Marfan syndrome and hypertension is dilatation of the aorta. The biological events that may lead to dissection are a decrease in the holding power of the internal layer, an increase in blood pressure, or an increase in aortic diameter combined with a decrease in wall thickness.

Aortic valve replacement with the freestyle stentless xenograft.

We performed aortic valve replacement with the Free-style stentless xenograft in 55 consecutive patients requiring a bioprosthesis. Thirty-four were male and 21 female, and all were in New York Heart Association class III to V. Ages ranged from 44 to 87 years (median, 74 years).

Comparison of implantation techniques using freestyle stentless porcine aortic valve.

Stentless porcine aortic valves demonstrate superior hemodynamic performance when compared with their stented counterparts. The technical considerations for implanting these valves can be demanding. The Medtronic Freestyle aortic root bioprosthesis resembles an allograft, has zero-pressure-fixed leaflets treated with an antimineralization agent, and can be implanted using a variety of techniques.

Impaired platelet aggregation after cardiopulmonary bypass in man: enhancement of collagen-induced aggregation in whole blood and plasma by adrenaline ex vivo.

1. We tested the effect of intravenous adrenaline at 0.55-1.

Deferoxamine cardioplegia reduces superoxide radical production in human myocardium.

Recent studies have demonstrated enhanced myocardial protection during ischemia using the oxygen free radical scavenger, deferoxamine. This effect of deferoxamine may be related either to its iron-chelating property or to intervention in an iron-independent mechanism. We tested the latter by determining the rate of superoxide anion production and the degree of lipid peroxidation in human myocardial tissue after including deferoxamine in cardioplegic solution.

Macroaggregation of platelets in plasma, as distinct from microaggregation in whole blood (and plasma), as determined using optical aggregometry and platelet counting respectively, is specifically impaired following cardiopulmonary bypass in man.

We determined changes in platelet aggregability following cardiopulmonary bypass, using optical aggregometry to assess macroaggregation in platelet-rich plasma (PRP), and platelet counting to assess microaggregation both in whole blood and PRP. Hirudin was used as the anticoagulant to maintain normocalcaemia. Microaggregation (%, median and interquartile range) in blood stirred with collagen (0.

Impending paradoxical embolism: a case report and literature review.

Paradoxical embolism occurs following the passage of embolic material from the venous to the arterial circulation through a right to left shunt--frequently a patent foramen ovale. The diagnosis is usually presumptive when arterial emboli occur in the appropriate clinical setting. We describe a case of impending paradoxical embolism in a patient with massive pulmonary embolism.

Topical aprotinin in cardiac operations.

We performed a prospective, randomized, double-blind trial of topical aprotinin versus placebo in 100 patients undergoing cardiac operations with cardiopulmonary bypass. Fifty-five patients received aprotinin. Forty underwent coronary artery bypass grafting (CABG) and 15 valve replacement +/- CABG.

An audit of cardiac surgery in patients aged over 70 years.

With an increasingly aged population, the number of patients requiring treatment for cardiovascular diseases will rise. Previous expectations of cardiac surgery in the over-seventies have been poor, with surgery being very much a last resort. We decided to test whether this was appropriate, and to determine whether the priority of surgery affected the outcome.

Aprotinin and bleeding in profoundly hypothermic perfusion.

Clinical observation led us to believe that aprotinin fails to preserve haemostatic function in patients undergoing deep hypothermic perfusion with or without circulatory arrest. A retrospective study was made of blood loss in 80 consecutive acute Type A dissection patients before and during the aprotinin era (1987-1992). After 1988 all patients were cooled below 20 degrees C pending circulatory arrest.

Congenital septation of the aortic arch with carotid stenosis.

A 14-year-old white boy presented with syncope and a left carotid bruit. Arch aortogram showed narrowing of the distal aortic arch, left carotid stenosis, and small left subclavian and vertebral arteries. When aortic arch replacement was carried out a vertical septum was found in the distal arch.

Replacement of the thoracic aorta with collagen-impregnated woven Dacron grafts. Early results.

We used the collagen-impregnated woven double-velour Dacron graft in 120 patients undergoing 122 aortic reconstructions. Seventy-nine aortic root, ascending, or arch replacements were performed during cardiopulmonary bypass with or without circulatory arrest; 53 of the 79 were for acute aortic dissection. In addition, three infants and one child underwent repair of truncus arteriosus.

Stentless aortic bioprosthesis? The way forward: early experience with the Edwards valve.

Tissue valve degeneration has been variably attributed to preservation and fixation methods. Additionally, a rigid valve ring might contribute to valve failure. The use of a nonstented porcine valve in the aortic position has clear hemodynamic advantages, and the lack of a stent may favorably influence long-term function.

Monocusp homograft VSD patch in atrioventricular canal with tetralogy of Fallot.

A monocusp aortic homograft was used to compensate for deficient right atrioventricular valve tissue during repair of complete atrioventricular canal defect with tetralogy of Fallot. The homograft was used to produce a comma-shaped ventricular septal defect patch together with the septal leaflet of the right atrioventricular valve, thus committing native leaflet tissue to left atrioventricular valve reconstruction. One year postoperatively the child is in New York Heart Association class I with no tricuspid regurgitation.

Amiodarone prophylaxis for tachycardias after coronary artery surgery: a randomised, double blind, placebo controlled trial.

Background: Arrhythmias are a common cause of morbidity after cardiac surgery. This study assessed the efficacy of prophylactic amiodarone in reducing the incidence of atrial fibrillation or flutter and ventricular arrhythmias after coronary artery surgery.

Methods: A double blind, randomised, placebo controlled trial.