Publications by authors named "Wesley Rosales"
Blockade of NKG2A/HLA-E interaction is a promising strategy to unleash the anti-tumor response. Yet the role of NKG2A CD8 T cells in the anti-tumor response and the regulation of NKG2A expression on human tumor-infiltrating T cells are still poorly understood. Here, by performing CITE-seq on T cells derived from head and neck squamous cell carcinoma and colorectal cancer, we show that NKG2A expression is induced on CD8 T cells differentiating into cytotoxic, CD39CD103 double positive (DP) cells, a phenotype associated with tumor-reactive T cells.
View Article and Find Full Text PDFArticle Synopsis
- The development of CITEViz streamlines the analysis of multi-omic single-cell sequencing, specifically CITE-Seq data, by allowing users to interactively gate cells without writing redundant code.
- CITEViz has been successfully applied to classify major blood cell populations and analyze cellular heterogeneity in monocytes, demonstrating its utility for robust cell classification.
- This R-Shiny app not only standardizes the gating process but also provides visualization tools for quality control metrics, enhancing the overall evaluation of CITE-Seq datasets.