Publications by authors named "Wesley C Turner"
Physiol Rep
December 2014
Article Synopsis
- Young airway smooth muscle (ASM) is typically hyperresponsive, but this responsiveness decreases as individuals mature into adulthood.
- The study tested whether neonatal allergic sensitization, specifically to ovalbumin in guinea pigs, could prevent this decline in responsiveness when there are no later allergen challenges.
- Results showed that while neonatal sensitization did not affect ASM force generation, it did maintain a heightened ability for shortening velocity and resistance, indicating that early-life sensitization preserves the hyperresponsive ASM phenotype into adulthood.
