Cellulose based biopolymer nanoscaffold: A possible biomedical applications.

In this work, a combination of cellulose nanofiber (CNF), coffee beans powder (CBP), and reduced graphene oxide (rGO) are used to design a nanowound dressing sheet (Nano-WDS), by vacuum pressure, for their sustained application in wound healing. Nano-WDS was analysed for its mechanical, antimicrobial, biocompatibility, etc., The Nano-WDS had favourable results of the tensile strength (12.

Quercetin impregnated chitosan-fibrin composite scaffolds as potential wound dressing materials - Fabrication, characterization and in vivo analysis.

The present study efforts at fabricating chitosan-fibrin composite (CF) scaffolds impregnated with quercetin for wound dressing application and aims at investigating their physicochemical properties. CF scaffolds were prepared by mixing acidic solution of chitosan with an alkaline solution of fibrin, to which quercetin (Q) was added, homogenized and lyophilized obtain Q-CF scaffold. FTIR spectra were used to determine the interactions between the functional groups of quercetin and CF scaffolds.

Chitosan-Fibrin Nanocomposites as Drug Delivering and Wound Healing Materials.

In the present study, chitosan-fibrin nanocomposites (CFNs) were prepared using a novel method and analysed for their physico-chemical properties. TEM and SEM studies revealed their size in the range of 24-28 nm with zeta potential value of + 16 mV. Anti-bacterial activity of CFN was investigated against Escherichia coli and Staphylococcus aureus.

Time-dependent biodistribution, clearance and biocompatibility of magnetic fibrin nanoparticles: an in vivo study.

Recently, bioretention and toxicity of injected nanoparticles in the body has drawn much attention in biomedical research. In the present study, 5 mg Fe per kg body weight of magnetic fibrin nanoparticles (MFNPs) were injected into mice intravenously and investigated for their blood clearance profile, biodistribution, haematology and pathology studies for a time period of 28 days. Moderately long circulation of MFNPs in blood was observed with probable degradation and excretion into the bloodstream via monoatomic iron forms.

Physiologically clotted fibrin--preparation and characterization for tissue engineering and drug delivery applications.

Fibrin used for biomedical applications is prepared by mixing concentrated solutions of fibrinogen and thrombin in presence of cross-linking agents such as Factor XIII or glutaraldehyde. The main drawbacks associated with this procedure include cost, complexity and time required for fibrin preparation. Hence, present study deals with the characterization of physiologically clotted fibrin (PF) for bone tissue engineering and drug delivery applications.

Deposition of superparamagnetic nanohydroxyapatite on iron-fibrin substrates: preparation, characterization, cytocompatibility and bioactivity studies.

In the present study, nanosized hydroxyapatite (nHAp) was formed on iron-fibrin substrates and its physico-chemical properties were characterized. The prepared iron-fibrin-nanohydroxyapatite (IF-nHAp) composite was needle shaped with an average width of about 30nm and length of 80nm. The vibrating sample magnetometer (VSM) was used to evaluate the superparamagnetic behavior of the nanocomposite, IF-nHAp.

Fibrin nanoparticles as Possible vehicles for drug delivery.

Background: Several issues have been raised emphasizing the harmful toxic effects of metal nanoparticles towards biological systems. Search of biological nanoparticles with excellent biocompatibility and bioavailability could address this problem.

Methods: Fibrin nanoparticles (FNP) were prepared using a novel technique and characterized for their physico-chemical properties.