Antiprotozoal Activity of Benzoylthiourea Derivatives against : Insights into Mechanism of Action.

For decades, only two nitroheterocyclic drugs have been used as therapeutic agents for Chagas disease. However, these drugs present limited effectiveness during the chronic phase, possess unfavorable pharmacokinetic properties, and induce severe adverse effects, resulting in low treatment adherence. A previous study reported that -(cyclohexylcarbamothioyl) benzamide (), -(-butylcarbamothioyl) benzamide (), and (4-bromo--(3-nitrophenyl) carbamothioyl benzamide () present selective antiprotozoal activity against all developmental forms of Y strain.

Antifungal Combination of Ethyl Acetate Extract of (DC.) L. P. Queiros Stem Bark With Amphotericin B in .

is the leading cause of cryptococcosis, an invasive and potentially fatal infectious disease. Therapeutic failures are due to the increase in antifungal resistance, the adverse effects of drugs, and the unavailability of therapeutic regimens in low-income countries, which limit the treatment of cryptococcosis, increasing the morbidity and mortality associated with these infections. Thus, new antifungal drugs and innovative strategies for the cryptococcosis treatment are urgently needed.