Publications by authors named "Wesam Aldosoky"
Background: Noise exposure and lower socioeconomic status (SES) are both independently linked to increased cardiovascular disease (CVD) risk. Although these factors frequently coexist, their combined impact and the underlying pathophysiological mechanisms remain poorly understood.
Objectives: This study aimed to evaluate the joint effects of high transportation noise exposure and lower SES on major adverse cardiovascular events (MACE) and the role of the neural-arterial axis in mediating this relationship.
Objective: We investigated the association between self-rated poor physical health (srPPH), a validated proxy measure of health-related quality of life, and age-adjusted cardiovascular mortality (AACVM) rates across overall U.S. counties and within various demographics.
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- Prior research was limited in understanding how cardiometabolic risk factors (CVDRFs), like hypertension and diabetes, mediate the link between anxiety/depression and cardiovascular disease (CVD).
- The study followed over 71,000 participants for a decade to assess the impact of anxiety/depression on the development of CVDRFs and the role of neuro-immune mechanisms, with findings showing a clear association and effect differences based on age and sex.
- Results indicated that anxiety/depression significantly increases the risk of developing CVDRFs, especially in younger women, and this relationship may be influenced by neuro-immune pathways.
Article Synopsis
- Depression and anxiety are linked to an increased risk of deep venous thrombosis (DVT), particularly in women with posttraumatic stress disorder (PTSD).
- A study involving over 106,000 participants found that PTSD significantly increases DVT risk, with a strong association in women compared to men.
- The relationship between PTSD and DVT appears to be influenced by changes in stress-related neural activity and heart rate variability, indicating potential areas for preventive treatments in at-risk individuals, especially women.
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- This study investigates how physical activity (PA) affects cardiovascular disease (CVD) and psychological health, particularly focusing on stress-related brain activity.
- It found that increased PA is linked to lower stress-related neural activity and a reduction in CVD events, with these effects being more pronounced in individuals with depression.
- The results suggest that engaging in PA may help decrease CVD risk partly by reducing stress impacts on the brain, especially for those suffering from depression.
Article Synopsis
- PTSD is linked to a higher risk of major adverse cardiovascular events (MACE), but the exact reasons for this connection are not well understood.
- Recent research indicates that neuro-immune mechanisms—such as increased stress-related neural activity, autonomic nervous system function, and inflammation—may be responsible for this link.
- The study found that these neuro-immune mechanisms (specifically stress-associated neural activity, heart rate variability, and inflammation markers) mediate the relationship between PTSD and MACE, suggesting that targeting these mechanisms could improve treatment for PTSD and reduce MACE risk.
Objectives: To investigate the associations between county-level proportions of adults not engaging in leisure-time physical activity (no LTPA) and age-adjusted cardiovascular mortality (AACVM) rates in the overall US population and across demographics.
Methods: Analysing 2900 US counties from 2011 to 2019, we used the Centers for Disease Control and Prevention (CDC) databases to obtain annual AACVM rates. No LTPA data were sourced from the CDC's Behavioural Risk Factor Surveillance System survey and county-specific rates were calculated using a validated multilevel regression and poststratification modelling approach.
Coronary Artery Disease (CAD) represents a persistent global health menace, particularly prevalent in Eastern European nations. Often asymptomatic until its advanced stages, CAD can precipitate life-threatening events like myocardial infarction or stroke. While conventional risk factors provide some insight into CAD risk, their predictive accuracy is suboptimal.
View Article and Find Full Text PDFCalcific aortic valve stenosis (CAS), the most prevalent valvular disease worldwide, has been demonstrated to frequently occur in conjunction with coronary artery disease (CAD), the third leading cause of death worldwide. Atherosclerosis has been proven to be the main mechanism involved in CAS and CAD. Evidence also exists that obesity, diabetes, and metabolic syndrome (among others), along with specific genes involved in lipid metabolism, are important risk factors for CAS and CAD, leading to common pathological processes of atherosclerosis in both diseases.
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