Flype: Software for enabling personalized medicine.

The advent of next generation DNA sequencing (NGS) has revolutionized clinical medicine by enabling wide-spread testing for genomic anomalies and polymorphisms. With that explosion in testing, however, come several informatics challenges including managing large amounts of data, interpreting the results and providing clinical decision support. We present Flype, a web-based bioinformatics platform built by a small group of bioinformaticians working in a community hospital setting, to address these challenges by allowing us to: (a) securely accept data from a variety of sources, (b) send orders to a variety of destinations, (c) perform secondary analysis and annotation of NGS data, (d) provide a central repository for all genomic variants, (e) assist with tertiary analysis and clinical interpretation, (f) send signed out data to our EHR as both PDF and discrete data elements, (g) allow population frequency analysis and (h) update variant annotation when literature knowledge evolves.

Reliability of fMRI during a continuous motor task: assessment of analysis techniques.

The purpose of this study was to determine which method of functional magnetic resonance image analysis had the highest reliability in cortical and cerebellar areas during a continuous motor task. Fourteen subjects underwent 4 testing trials during 2 testing sessions separated by 3 weeks. Subjects performed a joystick task.

Development and preliminary validation of a Satz-Mogel short form of the WAIS-III in a sample of persons with substance abuse disorders.

We developed a Satz-Mogel short form of the WAIS-III and evaluated its accuracy for predicting IQs of 50 men with substance abuse disorders. Means for age, education, and Full Scale IQ were 44.20 years (SD = 7.

Intestinal permeability in gastrointestinal disorders. Use of oral [99mTc]DTPA.

This study examined intestinal permeability in gastrointestinal disorders by measuring urinary recovery following oral administration of [99mTc]DTPA in 117 subjects. The mean percent of the ingested dose excreted in a 24-hr urine sample was 2.8 +/- 1.