The Role of the Disulfide Bridge in the Copper (II) Binding by the Cyclic His-Peptide.

In this paper, we present studies on the influence of the disulfide bridge on the copper (II) ions' binding abilities by the cyclic His-peptide. The studied ligand HKHPHRHCC consists of nine amino acids. The cyclic structure was obtained through a disulfide bridge between two cysteinyl groups.

Detailed Insight into the Interaction of Bicyclic Somatostatin Analogue with Cu(II) Ions.

Somatostatin analogues are useful pharmaceuticals in peptide receptor radionuclide therapy. In previous studies, we analyzed a new bicyclic somatostatin analogue (BCS) in connection with Cu(II) ions. Two characteristic sites were present in the peptide chain: the receptor- and the metal-binding site.

The Binding Ability of a Bicyclic Somatostatin Analogue Towards Cu(II) Ions.

Somatostatin (SST) analogues have aroused the interest of scientists for years. This group of compounds is used in the diagnosis and treatment of neuroendocrine tumors. However, new molecules useful as radiopharmaceuticals in targeted therapy are still searched for.