Effect of a group-based exercise program on balance in elderly.

Objective: To determine the effectiveness of 8-week group functional balance training classes on balance outcomes in community-dwelling veterans at risk for falls.

Design: Pre-test, post-test using retrospective data.

Setting: VISN 8 Patient Safety Center at James A.

Normal acute behavioral responses to moderate/high dose ethanol in GABAA receptor alpha 4 subunit knockout mice.

Background: gamma-Aminobutyric acid type A receptors (GABA(A)-Rs) have been implicated in mediating some of the behavioral effects of ethanol (EtOH), but the contribution of specific GABA(A)-R subunits is not yet fully understood. The GABA(A)-R alpha 4 subunit often partners with beta2/3 and delta subunits to form extrasynaptic GABA(A)-Rs that mediate tonic inhibition. Several in vitro studies have suggested that these extrasynaptic GABA(A)-Rs may be particularly relevant to the intoxicating effects of low doses of EtOH.

New insight into the role of the beta3 subunit of the GABAA-R in development, behavior, body weight regulation, and anesthesia revealed by conditional gene knockout.

Background: The beta3 subunit of the gamma-aminobutyric acid type A receptor (GABAA-R) has been reported to be important for palate formation, anesthetic action, and normal nervous system function. This subunit has also been implicated in the pathogenesis of Angelman syndrome and autism spectrum disorder. To further investigate involvement of this subunit, we previously produced mice with a global knockout of beta3.

[Trimethylaminuria (fish-odour syndrome)--hints for a new therapeutic option with desmopressin].

There is still no medical treatment available for the so-called fish-odour syndrome (trimethylaminuria). A recent coincidental observation points to a possible therapy with desmopressin. Theoretical considerations about the possible mechanism can explain the observed effects.

Activated carbon amendment as a treatment for residual DDT in sediment from a superfund site in San Francisco Bay, Richmond, California, USA.

Pesticide formulators formerly operating at Lauritzen Channel, a portion of San Francisco Bay near Richmond (CA, USA), caused contamination of sediment with dichlorodiphenyltrichloroethane (DDT). The present study evaluated the distribution of residual DDT in channel sediment six years following extensive remedial dredging. High DDT concentrations (up to 252 mg/ kg) were found in Young Bay Mud sampled across the channel.

Toxicological potential of 2-alkylcyclobutanones--specific radiolytic products in irradiated fat-containing food--in bacteria and human cell lines.

Food irradiation has been considered as a safe processing technology to improve food safety and preservation, eliminating efficiently bacterial pathogens, parasites and insects. This study aims to characterize the toxicological potential of 2-alkylcyclobutanones (2-ACBs), radiolytic derivatives of triglycerides, formed uniquely upon irradiation of fat-containing food. In irradiated food they are generated proportionally to fat content and absorbed radiation dose.

Low-index metamaterial designs in the visible spectrum.

Low-index metamaterial designs in the visible spectrum that are impedance matched to free space are presented. The unit cell of the periodic metamaterial design incorporates a magnetic resonator and silver meshes for respective control of the effective permeability and permittivity. A genetic algorithm is employed to optimize the metamaterial design to achieve a desired set of values for the index of refraction and the intrinsic impedance.

Comment on "Negative refractive index in artificial metamaterials".

We dispute Grigorenko's statement [Opt. Lett. 31, 2483 (2006)] that measuring only the reflection intensity spectrum is sufficient for determining the effective refractive index.

Isoflurane depression of spinal nociceptive processing and minimum alveolar anesthetic concentration are not attenuated in mice expressing isoflurane resistant gamma-aminobutyric acid type-A receptors.

Anesthetics produce immobility and depress spinal nociceptive processing, but the exact sites and mechanisms of anesthetic action are unknown. The gamma-aminobutyric acid type-A (GABAA) receptor is thought to be important to anesthetic action. We studied knock-in mice that had mutations in the alpha1 subunit of the GABAA receptor that imparts resistance to isoflurane in in vitro systems.

Genome sequence of Aedes aegypti, a major arbovirus vector.

We present a draft sequence of the genome of Aedes aegypti, the primary vector for yellow fever and dengue fever, which at approximately 1376 million base pairs is about 5 times the size of the genome of the malaria vector Anopheles gambiae. Nearly 50% of the Ae. aegypti genome consists of transposable elements.

Impact of enhanced external counterpulsation on peripheral circulation.

Enhanced external counterpulsation (EECP) is a noninvasive counterpulsation technique that reduces angina and improves exercise capacity in patients with coronary artery disease. Diastolic coronary perfusion is augmented by pneumatic compression of 3 sets of cuffs wrapped around the lower extremities. Although central hemodynamic changes are well investigated, almost no data exist about the changes of peripheral circulation during EECP.

Wanderers with cognitive impairment in Department of Veterans Affairs nursing home care units.

Objectives: To explore the extent of and factors associated with male nursing home residents who wander.

Design: Cross-sectional design with secondary data analyses.

Setting: One hundred thirty-four nursing home facilities operated by the Department of Veterans Affairs.

Liquid crystal clad near-infrared metamaterials with tunable negative-zero-positive refractive indices.

Near-infrared metamaterials that possess a reconfigurable index of refraction from negative through zero to positive values are presented. Reconfigurability is achieved by cladding thin layers of liquid crystal both as a superstrate and a substrate on an established negative-index metamaterial, and adjusting the permittivity of the liquid crystal. Numerical results show that the index of refraction for the proposed structure can be changed over the range from ?1 to +1.

Near-infrared metamaterials with dual-band negative-index characteristics.

Dual-band negative-index metamaterial designs in the near-infrared frequency range are presented and their performance is analyzed using a full-wave numerical electromagnetic scattering method. Negative effective permittivity is provided by a thin layer of metallic film. Negative effective permeabilities are supplied in two distinct frequency bands by magnetic resonators of different dimensions.

A multivariate fall risk assessment model for VHA nursing homes using the minimum data set.

Objectives: The purpose of this study was to develop a multivariate fall risk assessment model beyond the current fall Resident Assessment Protocol (RAP) triggers for nursing home residents using the Minimum Data Set (MDS).

Design: Retrospective, clustered secondary data analysis.

Setting: National Veterans Health Administration (VHA) long-term care nursing homes (N = 136).

Severe septic inflammation as a strong stimulus of myocardial NT-pro brain natriuretic peptide release.

Background: Septic shock (SS) has recently been identified as stimulus of N-terminal pro-brain natriuretic peptide (NT-proBNP) release. We tested whether SS mediates NT-proBNP release through cardiomyocyte necrosis. Moreover, the discriminative value of NT-proBNP for the distinction between SS and non-septic shock (NSS) was assessed.

The Research Associate Committee of the ACR Imaging Network.

Research associates (RAs) play an important role in ensuring the quality of clinical trials. They are largely responsible for maintaining the accuracy and timeliness of data collected and for complying with applicable regulations. At the ACR Imaging Network (ACRIN), a cooperative group, RAs have formed a committee with the mission of helping ACRIN achieve its goal of conducting quality multi-institutional imaging clinical trials.

Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning, and the righting reflex in mice engineered to express alpha1 gamma-aminobutyric acid type A receptors unresponsive to isoflurane.

Background: Enhancement of the function of gamma-aminobutyric acid type A receptors containing the alpha1 subunit may underlie a portion of inhaled anesthetic action. To test this, the authors created gene knock-in mice harboring mutations that render the receptors insensitive to isoflurane while preserving sensitivity to halothane.

Methods: The authors recorded miniature inhibitory synaptic currents in hippocampal neurons from hippocampal slices from knock-in and wild-type mice.

Nubac disc arthroplasty: preclinical studies and preliminary safety and efficacy evaluations.

Background: Disc arthroplasty is gaining popularity for treatment of low-back pain caused by degenerative disc disease (DDD). It can involve total disc replacement or partial disc or nucleus replacement (or augmentation). Compared with total disc replacement, nucleus replacement is less invasive, has less surgical risk, has faster postoperative recovery, and doesn't "burn bridges" should further surgery be required.

Clearspeech: a display reader for the visually handicapped.

Many domestic appliances and much office equipment is controlled using a keypad and a small digital display. Programming such devices is problematical for the blind and visually handicapped. In this paper, we describe a device that may be used to read the displays on these devices.

A highly effective one-pot synthesis of quinolines from o-nitroarylcarbaldehydes.

A highly effective one-pot Friedländer quinoline synthesis using inexpensive reagents has been developed. o-Nitroarylcarbaldehydes were reduced to o-aminoarylcarbaldehydes with iron in the presence of catalytic HCl (aq.) and subsequently condensed in situ with aldehydes or ketones to form mono- or di-substituted quinolines in high yields (66-100%).

1,3-Disubstituted-imidazo[1,5-a]pyrazines as insulin-like growth-factor-I receptor (IGF-IR) inhibitors.

A series of novel 8-amino-1,3-disubstituted-imidazo[1,5-a]pyrazines was designed and synthesized as IGF-IR inhibitors.

Acute reversible cardiomyopathy with cardiogenic shock in a patient with Addisonian crisis: a case report.

A 42 year-old female, admitted to the ICU, with Addisonian crisis developed acute cardiopulmonary failure after hydrocortisone therapy was initiated. An echocardiogram showed severe reduction in the left-ventricular ejection fraction. Additionally, profound ECG abnormalities with diffuse ST-elevation and decreased QRS-amplitudes occurred, whereas Troponin-I was only moderately increased.

GABAA receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol.

The neurotransmitter GABA mediates the majority of rapid inhibition in the CNS. Inhibition can occur via the conventional mechanism, the transient activation of subsynaptic GABAA receptors (GABAA-Rs), or via continuous activation of high-affinity receptors by low concentrations of ambient GABA, leading to "tonic" inhibition that can control levels of excitability and network activity. The GABAA-R alpha4 subunit is expressed at high levels in the dentate gyrus and thalamus and is suspected to contribute to extrasynaptic GABAA-R-mediated tonic inhibition.