Exploratory Investigation of Intestinal Function and Bacterial Translocation After Focal Cerebral Ischemia in the Mouse.

The gut communicates with the brain bidirectionally via neural, humoral and immune pathways. All these pathways are affected by acute brain lesions, such as stroke. Brain-gut communication may therefore impact on the overall outcome after CNS-injury.

Using a gluten oral food challenge protocol to improve diagnosis of wheat-dependent exercise-induced anaphylaxis.

Background: Oral wheat plus cofactors challenge tests in patients with wheat-dependent exercise-induced anaphylaxis (WDEIA) produce unreliable results.

Objective: We sought to confirm WDEIA diagnosis by using oral gluten flour plus cofactors challenge, to determine the amount of gluten required to elicit symptoms, and to correlate these results with plasma gliadin levels, gastrointestinal permeability, and allergologic parameters.

Methods: Sixteen of 34 patients with a history of WDEIA and ω5-gliadin IgE underwent prospective oral challenge tests with gluten with or without cofactors until objective symptoms developed.

Small intestinal permeability in older adults.

Abstract It is not yet clear whether intestinal mucosal permeability changes with advancing age in humans. This question is of high importance for drug and nutrition approaches for older adults. Our main objective was to answer the question if small intestinal barrier integrity deteriorates with healthy aging.

[Sex-specific differences in food intake, body weight and parameters of lipid metabolism (HDL-cholesterol, total cholesterol and triglycerides) in rats under various feeding conditions].

We compared the food intake, body weight as well as several parameters of the lipid metabolism in male and female rats fed with a diet high in carbohydrate content (HCD) or high in fat content (HFD). The absolute food intake was higher in male than in female animals. With regard to the relative food intake (per 1 000 g body weight), the sex-specific differences could be demonstrated only in the HCD rats.