A Phase 1 Trial of TPI 287 as a Single Agent and in Combination With Temozolomide in Patients with Refractory or Recurrent Neuroblastoma or Medulloblastoma.

Background: The primary aim of this Phase I study was to determine the maximum tolerated dose (MTD) of TPI 287 and the safety and tolerability of TPI 287 alone and in combination with temozolomide (TMZ) in pediatric patients with refractory or recurrent neuroblastoma or medulloblastoma. The secondary aims were to evaluate the pharmacokinetics of TPI 287 and the treatment responses.

Procedure: Eighteen patients were enrolled to a phase I dose escalation trial of weekly intravenous infusion of TPI 287 for two 28-day cycles with toxicity monitoring to determine the MTD, followed by two cycles of TPI 287 in combination with TMZ.

Mechanism of transcription activation at the comG promoter by the competence transcription factor ComK of Bacillus subtilis.

The development of genetic competence in Bacillus subtilis is regulated by a complex signal transduction cascade, which results in the synthesis of the competence transcription factor, encoded by comK. ComK is required for the transcription of the late competence genes that encode the DNA binding and uptake machinery and of genes required for homologous recombination. In vivo and in vitro experiments have shown that ComK is responsible for transcription activation at the comG promoter.

RHINE-AM. An inter-regional health information network for Europe.

RHINE is an inter-regional network in Europe having as an aim, the promotion of know-how transfer in the area of Information Technology methods and tools in the regions involved. The RHINE network's significance will be demonstrated in the health sector. Within the main scope of the project, the aims and objectives of RHINE and the participating partners encompass the extension of the nucleus network and the furtherance of Information Technology research.

Organising health systems for better care and performance by open information technology.

In this document the application of open information technology to assist in reforming healthcare systems of countries is being discussed. Present technologies demonstrated by HANSA in Western and Eastern Europe enable the integration of electronic patient records in existing systems, provide for flexibility and support the interoperability of different applications. However, computers and IT must not drive the required process of change.

The NUCLEUS integrated electronic patient dossier breakthrough and concepts of an open solution.

This paper addresses the requirements of healthcare providers and hospital managers vis-à-vis electronic patient records that can be integrated. It starts from some critical failure factors, found with previous attempts to standardise the electronic health record. Standardisation appears to be the key issue: the subject of standardisation requires delicate positioning.

Structuring the patient record: NUCLEUS (customisation environment for multi-media integrated patient records).

The NUCLEUS project (AIM A2025) develops a prototype of a multi-media integrated patient record, based on the concepts of intelligent act management as conceived in RICHE (Esprit 2221). Moreover, NUCLEUS creates facilities for the customisation of such patient record according to the requirements of the health professionals (physicians, nurses, therapists, etc.) who operate and consult the patient record.

Planning and management for health in periods of economic stringency and instability: a contingency approach.

The mid-1970s marked the end of the longest period of uninterrupted economic growth in history, and initiated in Europe--and other parts of the world--a period of economic stagnation and instability. Along with the prosperity explosion of the past, the pattern of health problems has changed and is still changing. Moreover, the demand for health care has kept on rising, without much improvement of health status in general.

A COMPARATIVE STUDY OF CLINICAL REACTION OBSERVED AFTER APPLICATION OF SEVERAL SMALLPOX VACCINES IN PRIMARY VACCINATION OF YOUNG ADULTS.

Four smallpox vaccines from different production laboratories were compared in primary vaccination of young adults. Morbidity rate, high fever rate and prolonged fever rate, as defined in this report, were used as gauges for pathogenic potency. Special batches were prepared, in addition, from two of these vaccines after three passages on calf skin.

Relationship between pock counts on chorio-allantoic membrane and percentages of "takes" in primary vaccination of human beings with two smallpox vaccines.

In view of doubts as to the potency level required to obtain nearly 100% successful vaccinations with the glycerolated smallpox vaccine prepared by the Netherlands National Institute of Public Health, its dose-effect relationship was compared with that of a glycerolated lymph from the Lister Institute of Preventive Medicine, England. The potency was estimated from pock counts on the chorio-allantoic membrane of chick embryos and the effect was judged from the "take" rate obtained in the primary vaccination of soldiers, the data being subjected to probit analysis.The relationship observed between the number of pock-forming units and the percentage of successful primary vaccinations was nearly identical with the two vaccines.