Int J Radiat Oncol Biol Phys
January 1990
A retrospective analysis of the incidence of radiation proctitis was performed in 154 patients with carcinoma of the prostate treated with external radiotherapy assisted by CT-scan planning from 1983 to 1985. An attempt was made to assess a dose-response relationship for proctitis. Multivariate Cox regression analysis showed that previous bowel disease or surgery, anterior rectal dose, and average rectal dose contributed to a higher risk of proctitis.
View Article and Find Full Text PDFForty-eight bladder cancers T2NXM0 with bad prognostic factors and 42 T3NXM0 growths, suitable for interstitial treatment, were submitted to 40 Gy external irradiation immediately followed by Cae137 Implant at "reduced dose". Intercurrent death corrected 5-year survival for both groups was about 80%. The influence of previously identified bad prognosticators (more than one TUR, WHO grade 3, 4, vascular invasion in the biopsy specimen, pathological IVP) was nearly eradicated.
View Article and Find Full Text PDFOut of 516 patients who entered in the two successive EORTC trials H2 and H5 for supra-diaphragmatic stages I and II Hodgkin's disease (HD), and who received an infra-diaphragmatic irradiation, 36 (7%) developed late radiation injuries of the gastrointestinal tract (GIT). Twenty-five patients presented with ulcers (stomach or duodenum), 2 with severe gastritis, 6 with small bowel obstruction or perforation and 3 patients had both an ulcer and bowel obstruction. A previous laparotomy played an important role.
View Article and Find Full Text PDFIn the categories T1, T2 and T3NxM0 bladder cancer, diameter not exceeding 5 cm, the treatment in the Rotterdam Radio-Therapy Institute consists of interstitial irradiation with needles containing radioactive material. The results of treatment and the role of additional external irradiation are discussed. Category T3NxM0 tumors diameter exceeding 5 cm are treated by external irradiation followed by cystectomy; the results are presented here.
View Article and Find Full Text PDFInt J Radiat Oncol Biol Phys
January 1985
A multivariate analysis of the prognostic factors was carried out with a Cox model on 1,139 patients with clinical Stage I + II Hodgkin's disease included in three controlled clinical trials. The following indicators had been prospectively registered: age, sex, systemic symptoms, erythrocyte sedimentation rate (ESR), number and sites of involved lymph node areas, histologic type, clinical stage, pattern of presentation, results of staging laparotomy when performed, as well as the date and type of treatment. A linear logistic analysis showed that most of the indicators are interrelated.
View Article and Find Full Text PDFUrol Clin North Am
November 1984
Bladder cancers are usually only poorly radiosensitive and require a very high dose of radiation in order to become completely eradicated. Radioactive material inserted interstitially, however, can deliver an extremely high dose to the bladder malignancy and still spare vulnerable adjacent tissues and organs. Indications for implantation, treatment results, and prognosis are presented.
View Article and Find Full Text PDFOne hundred and thirteen patients with non-seminoma testis and without clinical evidence of distant metastasis (category M0) have been analyzed with regard to the risk of subsequent metastasis after subdiaphragmatic irradiation. Important prognostic factors were: histology (malignant teratoma intermediate (MTI), malignant teratoma undifferentiated (MTU), T-category (T4, T less than 4), clinical regional and juxta-regional subdiaphragmatic lymph node involvement (N0, N1,2, N3,4) and vascular invasion in the orchidectomy specimen (V-, V+). If vascular invasion was considered, the histological type MTI or MTU lost its prognostic impact.
View Article and Find Full Text PDFTwo-hundred-seventy-nine patients, mainly with prostatic cancer category T3NXM0 and T4NXM0 , have been treated by a full-course of external irradiation. Five- and 10-year survivals and relapse-free survivals are comparable to reports in literature. Complications in about 24% of all cases are acceptable but might be reduced in future by more sophisticated techniques.
View Article and Find Full Text PDFA prospective study was undertaken in 1963 on the respective prognostic significances of erythrocyte sedimentation rate (ESR) and presence or absence of systemic symptoms in Hodgkin's disease. Six hundred seventy-six patients with clinical stages I or II were included in this study; 376 from 1963 to 1971 who were included in the H1 trial of the European Organization for Research and Treatment of Cancer (EORTC) and 300 who had been enrolled in the EORTC H2 trial from 1972 to 1976. All relevant data and long-term follow-up are available from 649 patients who were analyzed in this study.
View Article and Find Full Text PDFInt J Radiat Oncol Biol Phys
April 1983
Three-hundred-twenty-eight patients with bladder cancer category T2NxMo and 63 patients with category T3NxMo have been treated by 3 times 3.5 Gy external irradiation followed by a radium implant. Overall 5- and 10-year survival in the T2 category are 56%.
View Article and Find Full Text PDFInt J Radiat Oncol Biol Phys
February 1983
Forty-one patients with bladder cancer, T3NxMo, with a diameter not exceeding 5 cm, were treated by 3 times 350 rad external irradiation, radium implant at reduced dose, and an additional 3000 rad external irradiation ("Radium 55%"). Survival is excellent where there is a high or medium degree of differentiation without vascular invasion in the biopsy specimen; prognosis is poor if a low degree of differentiation is combined with vascular invasion. The future therapeutic approach will be adapted to this finding.
View Article and Find Full Text PDFInt J Radiat Oncol Biol Phys
November 1982
One hundred eighty-three patients with bladder cancer category T3NxMo (the diameter of the primary exceeding 5 cm), were treated by preoperative 40 Gy and simple cystectomy. Using only pretreatment information, the group with the best prognosis was characterized by a T3A-growth with a normal intravenous pyelography, with about a 75% cure rate. Before cystectomy, after irradiation the combination of a clinically assessed radiation-downstaged growth (T40GY less than 3) with normal urography, predicted the best chance of cure at about 80%.
View Article and Find Full Text PDFThe prognosis of 121 patients with a non-seminoma testicular tumor MTI or MTU was assessed. The clinical lymph node involvement and the T-category of the primary had a significant bearing on prognosis, which is completely determined by pulmonary relapse. The low-risk group (9% pulmonary relapse, all curable) is characterized by a primary category T1 or T2 with negative lymphangiography.
View Article and Find Full Text PDF