Publications by authors named "Wenzhu Chai"
Background: The neuroimmune network plays a crucial role in regulating mucosal immune homeostasis within the digestive tract. Synaptosome-associated protein 25 (SNAP-25) is a presynaptic membrane-binding protein that activates ILC2s, initiating the host's anti-parasitic immune response.
Methods: To investigate the effect of Moniezia benedeni (M.
Article Synopsis
- The study investigates the role of immunoglobulin E (IgE) in sheep’s small intestine, particularly focusing on how Moniezia benedeni infection affects IgE cell populations.
- The researchers created recombinant plasmids to produce a specific antibody against sheep IgE, allowing them to measure IgE levels and distribution in healthy and infected sheep.
- Results showed that IgE cell density and protein levels were significantly higher in infected sheep compared to healthy ones across all intestinal segments, indicating a strong immune response to the infection.
drives CD3 T cells residence in the sheep intestinal mucosal effector sites.
Front Vet Sci
February 2024
Introduction: T cells are the core of the cellular immunity and play a key role in the regulation of intestinal immune homeostasis. In order to explore the impact () infection on distributions of CD3 T cells in the small intestine of the sheep.
Methods: In this study, sheep pET-28a-CD3 recombinant plasmid were constructed and expressed in receptor cells, then the rabbit anti-sheep CD3 polyclonal antibody was prepared through recombinant protein inducing.