Integrated Transcriptomic and Metabolomic Analysis Reveal the Dynamic Process of Bama Hemp Seed Development and the Accumulation Mechanism of α-Linolenic Acid and Linoleic Acid.

Bama County is a world-famous longevity county in the Guangxi Province, China. Bama hemp is a traditional seed used in hemp cultivation in the Bama County. The seeds contain abundant unsaturated fatty acids, particularly linoleic acid (LA) and linolenic acid in the golden ratio.

The construction of a nomogram to predict the prognosis and recurrence risks of UPJO.

Objective: This study was conducted to explore the risk factors for the prognosis and recurrence of ureteropelvic junction obstruction (UPJO).

Methods: The correlation of these variables with the prognosis and recurrence risks was analyzed by binary and multivariate logistic regression. Besides, a nomogram was constructed based on the multivariate logistic regression calculation.

Morpho-physio-biochemical, molecular, and phytoremedial responses of plants to red, blue, and green light: a review.

Light is a basic requirement to drive carbon metabolism in plants and supports life on earth. Spectral quality greatly affects plant morphology, physiology, and metabolism of various biochemical pathways. Among visible light spectrum, red, blue, and green light wavelengths affect several mechanisms to contribute in plant growth and productivity.

Identification of the expression patterns and potential prognostic role of m6A-RNA methylation regulators in Wilms Tumor.

Background: To explore the potential role of m6A methylation modification in Wilms Tumor (WT) by m6A-RNA Methylation (m6A) regulators.

Methodology: The association of m6A modification patterns with immune and prognostic characteristics of tumors was systematically evaluated using 19 m6A regulators extracted from Wilms Tumor's samples in public databases. A comprehensive model of "m6Ascore" was constructed using principal component analysis, and its prognostic value was evaluated.

Artificial multi-enzyme cascades and whole-cell transformation for bioconversion of C1 compounds: Advances, challenge and perspectives.

Artificial multi-enzyme cascades bear great potential for bioconversion of C1 compounds to value-added chemicals. Over the past decade, massive efforts have been devoted to constructing multi-enzyme cascades to produce glycolic acid, rare functional sugars and even starch from C1 compounds. However, in contrast to traditional fermentation utilizing C1 compounds with the expectation of competitive economic performance in future industrialization, multi-enzyme cascades systems in the proof-of-concept phase are facing the challenges of upscaling.

Enhancement of Circularly Polarized Luminescence from Pulsating Nanotubules.

Enhancing the dissymmetry factor (g ) is a crucial issue in developing circularly polarized luminescence (CPL) materials. Herein, based on supramolecular self-assembly of diethyl l-glutamate-cyanodiarylethene (L-GC) in mixed solution of EtOH-H O with different water fraction, enhanced circularly polarized emission from pulsating nanotubules is realized. In the mixture of ethanol and water (30/70, v/v), L-GC self-assembles into roll-up-type dense nanotubes and shows l-CPL.

Ultrasound Education in an Elective Course in the Undergraduate Medical Curriculum Improves Students' Subjective Learning and Clinical Rotation and Residency Preparedness.

Objectives: Studies have demonstrated that students are able to improve their understanding of anatomy, physical exam skills, and clinical knowledge when ultrasound is incorporated into their education. This study investigates whether students enrolled in an elective with significant use of ultrasound (ACS) in their preclinical years subjectively improved their preparedness for clinical rotations, residency, and learning in several subjects.

Methods: This was a retrospective analysis of an anonymous online needs assessment survey sent to 384 third- and fourth-year medical students.

Intercropping of kenaf and soybean affects plant growth, antioxidant capacity, and uptake of cadmium and lead in contaminated mining soil.

Intercropping is considered a sustainable agricultural practice that can reduce the environmental impacts on agriculture. Our study investigated the morphology, physiology, and cadmium (Cd) and lead (Pb) uptake of kenaf (Hibiscus cannabinus L.) and soybean (Glycine max L.

Circularly Polarized Luminescence Switching Driven by Precisely Tuned Supramolecular Interactions: From Hydrogen Bonding to π-π Interaction.

It is highly challenging to achieve circularly polarized luminescence (CPL) switching by precisely tuning supramolecular interactions and unveiling the mechanism of supramolecular chirality inversion. Herein, we demonstrated CPL switching based on diethyl l-glutamate-9-cyanophenanthrene (LGCP) and diethyl l-glutamate-pyrene (LGP) via the precise regulation of supramolecular interactions. LGCP assembly driven by hydrogen bonding showed right CPL, while LGP assembly driven by π-π interaction led to left CPL.

Low-Pressure Sensitive Piezochromic Fluorescence Switching of Tetraphenylethylene-Anthraquinone.

Sensing of low-pressure signals is of great importance for cutting-edge technologies. Organic piezochromic molecules offer a promising library of pressure sensitive materials which can be tailor-designed toward specific requirements. However, very few examples of low-pressure sensitive piezochromic fluorescent molecules have been obtained till date, and the underlying mechanisms are still in its infancy.

Polymorphic Covalent Organic Frameworks: Molecularly Defined Pore Structures and Iodine Adsorption Property.

Radioactive iodine-capturing materials are urgently needed for the emerging challenges in nuclear waste disposal. The various pore structures of covalent organic frameworks (COFs) render them promising candidates for efficient iodine adsorption. However, the detailed structure-property relationship of COFs in iodine adsorption remains elusive.

An exploration into the application of specialty-orientated CBL pedagogy in undergraduate teaching in pediatric surgery.

Objective: This study aims to identify whether the specialty-oriented case-based learning (CBL) pedagogy contributes to the teaching of basic theory and practical operation in undergraduate clinical teaching in pediatric surgery, and to assess the satisfaction of undergraduates.

Methods: A total of 72 undergraduates in Grade 2016 who interned at Qilu Hospital of Shandong University were enrolled in this study. All these undergraduates voluntarily participated in this experimental study.

An Improved Crucible Spatial Bubble Detection Based on YOLOv5 Fusion Target Tracking.

A three-dimensional spatial bubble counting method is proposed to solve the problem of the existing crucible bubble detection only being able to perform two-dimensional statistics. First, spatial video images of the transparent layer of the crucible are acquired by a digital microscope, and a quartz crucible bubble dataset is constructed independently. Secondly, to address the problems of poor real-time and the insufficient small-target detection capability of existing methods for quartz crucible bubble detection, rich detailed feature information is retained by reducing the depth of down-sampling in the YOLOv5 network structure.

Effects of Four Cropping Patterns of on Rhizosphere Microbiome Structure and Replant Disease.

Replant disease caused by continuous cropping obstacles commonly occurs in a consecutive monoculture. To reveal the mechanisms contributing to the continuous cropping obstacles of , four cropping patterns (fallow, -rice rotation, newly planted , and 2-year consecutive monoculture) were designed, and Illumina MiSeq (16S rDNA and ITS) was utilized to detect shifts in the microbial community in the rhizosphere. Our result showed that planting of significantly reduced soil pH.

Transcriptomic and functional analysis provides molecular insights into multicellular trichome development.

Trichomes, the hair-like structures located on aerial parts of most vascular plants, are associated with a wide array of biological processes and affect the economic value of certain species. The processes involved in unicellular trichome formation have been well-studied in Arabidopsis (Arabidopsis thaliana). However, our understanding of the morphological changes and the underlying molecular processes involved in multicellular trichome development is limited.

Reversible Three-Color Fluorescence Switching of an Organic Molecule in the Solid State via "Pump-Trigger" Optical Manipulation.

In photoswitches that undergo fluorescence switching upon ultraviolet irradiation, photoluminescence and photoisomerization often occur simultaneously, leading to unstable fluorescence properties. Here, we successfully demonstrated reversible solid-state triple fluorescence switching through "Pump-Trigger" multiphoton manipulation. A novel fluorescence photoswitch, BOSA-SP, achieved green, yellow, and red fluorescence under excitation by pump light and isomerization induced by trigger light.

Covalent Organic Frameworks with Electron-Rich and Electron-Deficient Structures as Water Sensing Scaffolds.

Covalent organic frameworks (COFs) have potential applications in gas storage, catalysis, proton conduction, sensing, and chemical removal etc., due to their highly crystalline structure, good stability, porosity, as well as structural and functional controllability. Herein, by using electron-rich group, 2,5-bis(methylthio)terephthalaldehyde (BMTA), and electron-deficient group, 1,3,5-tris-(4-aminophenyl)triazine (TAPT) as building blocks, TAPT-BMTA-COF is constructed through Schiff-base reaction.

Phase-field modelling of the effect of density change on solidification revisited: model development and analytical solutions for single component materials.

In this paper the development of a physically consistent phase-field theory of solidification shrinkage is presented. The coarse-grained hydrodynamic equations are derived directly from the N-body Hamiltonian equations in the framework of statistical physics, while the constitutive relations are developed in the framework of the standard phase-field theory, by following the variational formalism and the principles of non-equilibrium thermodynamics. To enhance the numerical practicality of the model, quasi-incompressible hydrodynamic equations are derived, where sound waves are absent (but density change is still possible), and therefore the time scale of solidification is accessible in numerical simulations.

[Phase II clinical trial of neoadjuvant therapy with carboplatin plus paclitaxel for locally advanced triple-negative breast cancer].

Objective: To evaluate the efficacy, safety and survival of combination of carboplatin plus paclitaxel as neoadjuvant chemotherapy (NACT) for patients with locally advanced triple-negative breast cancer (TNBC), and explore an optimal regimen for TNBC.

Methods: Patients with core needle biopsy confirmed pathological diagnosis of IIA ∼ IIIC invasive breast cancer, negative for estrogen and progesterone receptors and HER2 by immunohistochemistry, and with indication for NACT were eligible in this study. The biopsy tumor tissues were tested for CK5/6, CK14, EGFR and Ki67.