Publications by authors named "Wenyong Huang"

Article Synopsis
  • * A new bio-derived vaccine called TMV@CpG, which combines glioma cell membrane vesicles and TLR9 agonist CpG, is developed using a microneedle delivery system (MN-TMV@CpG) that enhances immune response.
  • * In animal studies, MN-TMV@CpG effectively reversed the tumor's immune-suppressing environment, inhibited tumor growth, and improved survival rates, highlighting its potential as a viable immunotherapy option for gliomas.
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Purpose: This prospective cohort study investigated the longitudinal relationship between hypertension (HTN), defined by the 2017 ACC/AHA guidelines, and changes in choroidal thickness (CT) in patients with type 2 diabetes.

Methods: Patients aged 30-80 years from the Guangzhou Diabetic Eye Study were categorized into non-HTN, stage 1-HTN, and stage 2-HTN groups based on BP criteria. Macular and parapapillary CT were measured using swept-source optical coherence tomography (SS-OCT).

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Article Synopsis
  • - This study aimed to explore the link between mean ocular perfusion pressure (MOPP), cerebrospinal fluid pressure (CSFP), and the occurrence of diabetic retinopathy (DR) in Southern Chinese individuals with type 2 diabetes (T2DM).
  • - Conducted with 1,224 participants, the research involved measuring blood pressures and calculating MOPP and CSFP; results showed that higher MOPP is associated with an increased risk of DR incidence but not with its progression or regression.
  • - The findings suggest that monitoring MOPP and blood pressure may help prevent or delay the onset of DR in T2DM patients, indicating MOPP could serve as a useful marker for detecting DR incidence.
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Purpose: The purpose of this study was to investigate whether the rapid rate of peripapillary retinal nerve fiber layer (pRNFL) thinning in short-term is associated with the future risk of developing diabetic retinopathy (DR).

Methods: This prospective cohort study utilized 4-year follow-up data from the Guangzhou Diabetic Eye Study. The pRNFL thickness was measured by optical coherence tomography (OCT).

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Purpose: To investigate sex-specific differences in associations of abdominal obesity indexes, systemic factors, and diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM) subjects with normal body mass index (BMI).

Methods: This cross-sectional study comprised 653 T2DM subjects (402 women and 251 men) with normal BMI (18.5 kg/m View Article and Find Full Text PDF

Article Synopsis
  • The study aimed to analyze changes in choroidal thickness (CT) and ganglion cell-inner plexiform layer thickness (GC-IPLT) in different types of type 2 diabetes mellitus (T2DM) patients over a 4-year period.
  • It categorized patients into five groups based on their β-cell function and insulin resistance, measuring CT and GC-IPLT at the start and after four years using advanced imaging techniques.
  • Results showed significant thinning of both CT and GC-IPLT in all groups, with SIDD patients experiencing the fastest decline in CT and SIRD showing the greatest loss in GC-IPLT, indicating microvascular damage and early retinal degeneration linked to these diabetes phenotypes.
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Diabetic macular edema (DME) has emerged as the foremost cause of vision loss in the population with diabetes. Early detection of DME is paramount, yet the prevailing screening, relying on two-dimensional and labor-intensive fundus photography (FP), results in frequent unwarranted referrals and overlooked diagnoses. Self-imaging optical coherence tomography (SI-OCT), offering fully automated, three-dimensional macular imaging, holds the potential to enhance DR screening.

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Background: Chronic Kidney Disease (CKD), a complex and multifaceted health issue, significantly contributes to global mortality rates. Accompanying chronic conditions, depression notably exacerbates health outcomes, increasing both mortality risk and the burden on affected individuals. This study employs bibliometric and visual analytics to evaluate the evolution, current trends, and future research directions in the field of CKD and depression.

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Article Synopsis
  • Primary diabetes care and diabetic retinopathy (DR) screening face challenges due to a lack of trained primary care physicians, especially in low-resource areas.
  • The integrated image-language system, DeepDR-LLM, combines a language model and deep learning to help PCPs provide tailored diabetes management recommendations, showing comparable or better accuracy than PCPs in diagnosing DR.
  • In a study, patients assisted by DeepDR-LLM demonstrated improved self-management and adherence to referral recommendations, indicating that the system enhances both care quality and patient outcomes.
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  • Researchers developed three new cyclometalated Ru(II) complexes (RuIQ9, RuIQ10, and RuIQ11) and tested their effectiveness against lung cancer cells, finding they were more cytotoxic than common treatments including cisplatin.
  • The complexes showed low toxicity to normal cells and zebrafish embryos while disrupting cancer cell functions, leading to cell death via mechanisms like cell cycle arrest and elevated ROS levels.
  • Importantly, RuIQ9-11 were able to overcome drug resistance in cancer cells by inhibiting key proteins that promote survival, making them promising candidates for lung cancer therapies.
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Purpose: To identify longitudinal metabolomic fingerprints of diabetic retinopathy (DR) and to evaluate their usefulness in predicting DR development and progression.

Design: Multicenter, multiethnic cohort study.

Participants: This study included 17 675 participants from the UK Biobank (UKB) who had baseline prediabetes or diabetes, identified in accordance with the 2021 American Diabetes Association guidelines, and were free of baseline DR and an additional 638 participants with type 2 diabetes mellitus from the Guangzhou Diabetic Eye Study (GDES) for external validation.

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Background: To present an unusual case of abnormal LCA expression and CD43 in SCLC and to review the reported literature to avoid potential diagnostic pitfalls.

Case Presentation: A 73-year-old male patient suffered from persistent back pain for more than one month. MRI revealed a compression fracture of the L1-L5 vertebra.

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Purpose: The aim of this study was to investigate the association between myopia and longitudinal changes in peripapillary retinal nerve fiber layer (pRNFL) thickness in type 2 diabetic patients without diabetic retinopathy (DR).

Methods: A total of 1069 participants with a median follow-up time of 1.9 years were included in this study.

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POU class 2 homeobox 3 (POU2F3)-positive small cell bladder carcinoma (SCBC) is an extremely rare entity, and its clinicopathologic features have not been fully described. Here, we investigated the clinicopathologic features of 4 cases of POU2F3-positive small cell bladder carcinoma (SCBC) and reviewed the literature. We collected 12 cases of SCBC from our departmental archives and detected the expression of POU2F3 by immunohistochemical (IHC) staining.

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Background: Visceral adipose tissue plays an active role in the pathogenesis of type 2 diabetes and vascular dysfunction. The lipid accumulation product (LAP), visceral adiposity index (VAI), and Chinese VAI (CVAI) have been proposed as simple and validated surrogate indices for measuring visceral adipose tissue. However, the evidence from prospective studies on the associations between these novel indices of visceral obesity and diabetic retinopathy (DR) remains scant.

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Tumor micronecrosis is a pathological feature that reflects malignant biological behavior in hepatocellular carcinoma (HCC). However, whether micronecrosis can optimize HCC staging systems remains unilluminated. A total of 1632 HCC patients who underwent curative hepatectomy in four institutions from January 2014 to December 2021 were enrolled in this study.

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Background And Aims: To assess the relationship between frailty phenotypes and the risk of MVD among prediabetics in two prospective cohorts.

Methods: The study included 66,068 and 226 participants with prediabetes from the UK Biobank (UKB) and Chinese Ocular Imaging Project (COIP) in Guangzhou, China, respectively. Frailty was evaluated using the Fried phenotype, which includes weight loss, fatigue, low grip strength, low physical activity, and slow walking pace.

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Background: Melan-A/MART-1 is a melanocytic differentiation marker recognized as an antigen on melanoma cells. It is a useful diagnostic marker for pathologists in the diagnosis of melanocytic tumors. However, we recently found that Melan-A can be expressed in some non-melanocytic carcinomas that are rarely reported in the literature.

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Background: The Chinese government has invested significant resources to build many rural healthcare stations. However, in the face of convenient medical paths and accessible medical resources, the utilization rate of health services for older adults in rural areas is surprisingly low. This study explored why health-seeking behavior among older adults in rural China was not active.

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Purpose: The purpose of this study was to investigate a 6-year change in cataract surgical coverage (CSC), effective cataract surgical coverage (eCSC), and visual outcomes in an elderly population in rural southern China.

Design: This is a prospective population-based study with a 6-year follow-up.

Methods: The study included rural residents aged 50 years and above in southern China with comprehensive eye examinations at baseline and follow-up in 2014 and 2020, respectively.

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Objectives: To evaluate the feasibility and accuracy of a portable, self-imaging optical coherence tomography (OCT) for measuring central subfield thickness (CST) and achieving diagnostic concordance for retinal lesions compared with clinic-based spectral-domain OCT (SD-OCT).

Methods: This comparative, cross-sectional study was conducted between August 2020 and February 2021. Two groups of adult participants were recruited: (1) a selected cohort of 160 participants with confirmed diagnosis and (2) a consecutive cohort of 315 participants recruited randomly.

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Background: The association between serum cystatin C level and vascular outcomes has not been fully elucidated in diabetes and is unclear in prediabetes. We aim to evaluate whether cystatin C level predicts future risk for mortality and vascular outcomes in prediabetes and diabetes.

Methods: A total of 85,371 participants with prediabetes and diabetes, and available baseline cystatin C in the UK biobank were included with a 14-year follow-up.

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