Circ-HMGCS1, an Indicator of Survival and Prognosis in Cervical Cancer Patients.

Background: The aim was to investigate circ-HMGCS1 expression and its correlation with clinical features and survival in cervical cancer (CC) patients.

Methods: This prospective study recruited 100 patients with CC who underwent surgical resection. Circ-HMGCS1 expression was measured by RT-qPCR.

Novel conjugated small molecule-based nanoparticles for NIR-II photothermal antibacterial therapy.

Single organic small molecule-based nanoparticles (CNPs) with strong responses within the NIR-II (1000-1350 nm) bio-window were prepared, and successfully applied as a highly efficient photothermal antibacterial agent for the first time. CNPs exhibit an outstanding bacteria inhibition efficiency of almost 100% against ( with a high photothermal conversion efficiency (PTCE) of 49% under NIR-II laser irradiation (1064 nm) for 8 min.

880 nm NIR-Triggered Organic Small Molecular-Based Nanoparticles for Photothermal Therapy of Tumor.

Photothermal therapy (PTT) has received constant attention as an efficient cancer therapy method due to locally selective treatment, which is not affected by the tumor microenvironment. In this study, a novel 880 nm near-infrared (NIR) laser-triggered photothermal agent (PTA), 3TT-IC-4Cl, was used for PTT of a tumor in deep tissue. Folic acid (FA) conjugated amphiphilic block copolymer (folic acid-polyethylene glycol-poly (β-benzyl-L-aspartate), FA-PEG-PBLA) was employed to encapsulate 3TT-IC-4Cl by nano-precipitation to form stable nanoparticles (TNPs), and TNPs exhibit excellent photothermal stability and photothermal conversion efficiency.

[Biological evaluation of artificial skin substitute].

Multiple kinds of Artificial Skin Substitute are now available. However, except for the Homo Skin Graft there is no Artificial Skin Substitute that can be used as permanent Artificial Skin Substitute. During the past 20 years, more and more scholars around the world have expressed increased interests in the research and development of Artificial Skin Graft that can be utilized as satisfying permanent Artificial Skin Substitute.