Publications by authors named "Wenyin Shi"
Background: Many previous studies have investigated the prognostic value of body mass index (BMI) for GBM outcomes with varying results. We present a comprehensive literature review and meta-analysis investigating BMI as a prognostic value in GBM.
Methods: A systematic review of literature on adult patients with GBM published between 1999 and 2023 was conducted within OVID Medline, Pubmed, and Scopus.
Purpose: Uveal melanoma (UM) represents the most prevalent and aggressive intraocular malignancy in adults. This study examined the outcomes of patients diagnosed with high-risk UM who underwent fractionated stereotactic radiosurgery (fSRS) treatment utilizing a novel LINAC-based frameless technique.
Design: Retrospective, interventional case series.
Background: Glioma is a primary malignant brain tumor with a poor prognosis. Glioma-related biomarkers need to be identified to enable the personalized treatment of and predict the prognosis of glioma patients. Cuproptosis is an unusual mechanism of cell death, and is closely associated with disease progression and the immune-microenvironment of the tumor.
View Article and Find Full Text PDFBackground: Glioblastoma is the most aggressive adult primary brain cancer, characterized by significant heterogeneity, posing challenges for patient management, treatment planning, and clinical trial stratification.
Methods: We developed a highly reproducible, personalized prognostication and clinical subgrouping system using machine learning (ML) on routine clinical data, MRI, and molecular measures from 2,838 demographically diverse patients across 22 institutions and 3 continents. Patients were stratified into favorable, intermediate, and poor prognostic subgroups (I, II, III) using Kaplan-Meier analysis (Cox proportional model and hazard ratios [HR]).
Purpose: Many patients with skull base meningiomas (SBMs) develop cranial neuropathies, though there is a paucity in literature regarding cranial neuropathy improvement following treatment. This is even more profound when isolating for patients who received stereotactic radiotherapy (SRT) as their primary treatment without additional open surgery. Our goal was to investigate the effect of SRT on cranial neuropathies secondary to SBMs and identify predictors of favourable treatment response.
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- Glioblastoma (GBM) is an aggressive brain tumor that often infiltrates beyond its visible boundaries, making treatment challenging with standard surgical and chemoradiotherapy approaches.
- A new method was developed that combines expert insights and data augmentation to improve predictions of tumor infiltration using preoperative magnetic resonance imaging (mpMRI) scans from 229 patients.
- The model was validated through cross-institutional tests, showing varying effectiveness in predicting tumor recurrence, with odds ratios indicating strong potential for guiding targeted treatment strategies.
Purpose: Glioblastoma (GBM) is the most common primary brain cancer in adults with a very poor prognosis. Metabolic drivers of tumorigenesis are highly relevant within the central nervous system, where glucose is the critical source of energy. The impact of obesity on survival outcomes in patients with GBM is not well established.
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- Tumor Treating Fields (TTFields) therapy, approved for recurrent and newly diagnosed glioblastoma, disrupts cancer cell processes and has undergone a long-term safety analysis involving over 25,000 patients across multiple countries.* -
- The study found that 73% of patients experienced all-cause adverse events, while 56% had TTFields-related events, with the most common issues being localized skin reactions and sensations like tingling and warmth.* -
- Overall, TTFields therapy showed good tolerability and a consistent safety profile across different age groups, sexes, and diagnoses, indicating its potential for broad use in treating central nervous system malignancies.*
The quality of radiation therapy (RT) treatment plans directly affects the outcomes of clinical trials. KBP solutions have been utilized in RT plan quality assurance (QA). In this study, we evaluated the quality of RT plans for brain and head/neck cancers enrolled in multi-institutional clinical trials utilizing a KBP approach.
View Article and Find Full Text PDFVulvovaginal candidiasis (VVC) is a prevalent condition affecting a significant portion of women worldwide. Licochalcone A (LA), a natural compound with diverse biological activities, holds promise as a protective agent against Candida albicans (C. albicans) infection.
View Article and Find Full Text PDFObjective: Treatment of craniopharyngioma typically entails gross total resection (GTR) or subtotal resection with adjuvant radiation (STR-RT). We analyzed outcomes in adults with craniopharyngioma undergoing GTR versus STR-RT.
Methods: This retrospective study enrolled 115 patients with craniopharyngioma in 5 institutions.
Sex-Specific Differences in Patients with -Wild-Type Grade 4 Glioma in the ReSPOND Consortium.
AJNR Am J Neuroradiol
September 2024
Article Synopsis
- The study aimed to explore sex-based differences in patients with glioblastoma to enhance personalized treatment and improve outcomes, focusing on differences in tumor parameters and survival.
- Data from 1832 patients was analyzed, revealing that women were diagnosed at an older median age and had lower tumor volumes compared to men, who generally had higher performance scores.
- Despite these differences in tumor characteristics, the research found no significant discrepancies in survival outcomes or mortality rates between sexes, although certain factors like age and treatment type influenced mortality risk for both genders.
Article Synopsis
- Radiation treatment has become the preferred option for uveal melanoma, moving away from the more invasive enucleation approach; a new frameless LINAC solution for fractionated stereotactic radiosurgery (fSRS) was developed to preserve the eye.
- A unique ocular localization box was created featuring adjustable LED lights for patient focus, eye position monitoring with a CCD camera, and tools to track eye movement, ensuring targeted and effective treatment sessions.
- Initial trials with 10 patients showed that the localization box was effective and well-tolerated, yielding high accuracy for positioning with minimal setup errors, paving the way for future trials to further assess its effectiveness and consistency in various settings.*
Article Synopsis
- Gliomatosis cerebri (GC) is a rare and aggressive brain tumor that affects multiple lobes and is associated with a poorer prognosis compared to other gliomas, despite being classified differently under new WHO guidelines.
- The case study describes a 64-year-old male with GBM and extensive GC who responded well to treatment with tumor-treating fields (TTFields) combined with radiation and chemotherapy, showing significant improvement in his condition shortly after treatment.
- Though his glioma recurred 11 months after surgery, the aggressive GC remained under control, leading to a progression-free survival of 11 months and an overall survival of 17 months before his passing.
Background And Objective: The blood-brain barrier (BBB) serves as a dynamic, selective shield, safeguarding the central nervous system (CNS) by separating the brain from circulating blood, preserving its microenvironment, and ensuring stability. However, in the presence of brain pathology, drug delivery across the BBB and blood-tumor barrier (BTB) becomes challenging, hindering effective treatments. Borneol exhibits promise in bidirectionally modulating the BBB under pathological conditions, suggesting at potential clinical applications for related diseases.
View Article and Find Full Text PDFPurpose: Whole-brain radiation therapy (WBRT) is a common treatment for brain metastases and is frequently associated with decline in neurocognitive functioning (NCF). The e4 allele of the apolipoprotein E (APOE) gene is associated with increased risk of Alzheimer disease and NCF decline associated with a variety of neurologic diseases and insults. APOE carrier status has not been evaluated as a risk factor for onset time or extent of NCF impairment in patients with brain metastases treated with WBRT.
View Article and Find Full Text PDFPrevious work has reported the design of a novel thermobrachytherapy (TBT) balloon implant to deliver magnetic nanoparticle (MNP) hyperthermia and high-dose-rate (HDR) brachytherapy after brain tumor resection, thereby their synergistic effect. This paper presents an evaluation of the robustness of the balloon device, compatibility of its heat and radiation delivery components, as well as thermal and radiation dosimetry of the TBT balloon. TBT balloon devices with 1 and 3 cm diameter were evaluated when placed in an external magnetic field with a maximal strength of 8.
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- A randomized phase II clinical trial investigated the effectiveness of cediranib, a drug targeting vascular growth factors, when combined with radiation and temozolomide in newly diagnosed glioblastoma patients.
- Out of 158 participants, 137 were eligible, showing a 6-month progression-free survival (PFS) rate of 46.6% for cediranib versus 24.5% for the placebo, indicating a significant improvement.
- Although cediranib improved PFS, there was no notable difference in overall survival, and patients receiving cediranib experienced more serious adverse events compared to those on placebo.
Article Synopsis
- This paper introduces an integrated feathering technique for craniospinal irradiation aimed at enhancing dosimetry and overall treatment efficiency.
- It emphasizes improvements in workflow for dosimetrists, physicists, physicians, and therapists, leading to better patient safety and reduced portal imaging time.
- Unlike previous publications that focused on technical aspects, this article specifically focuses on the treatment planning process, including field design and weighting.
Article Synopsis
- Fractionated stereotactic radiotherapy (FSRT) is effective for treating nonfunctional pituitary adenomas, showing high tumor control rates of 94.3% for adjuvant therapy and 95.0% for therapy upon progression.
- A study of 75 patients over a median follow-up of 53 months indicated that early treatment (adjuvant) led to a slightly higher rate of new endocrine issues compared to delayed treatment (on-progression).
- The results suggest that monitoring and delaying FSRT until tumor progression might reduce the risk of developing complications like hypopituitarism while maintaining effective tumor control.
Article Synopsis
- Radiation therapy is crucial for treating glioblastoma (GBM), but it can cause scalp toxicity, affecting patient quality of life.
- This study compared traditional radiation techniques to a scalp-sparing volumetric modulated arc therapy (SSV) in GBM patients to see if it could minimize scalp radiation exposure while still effectively targeting the tumor.
- Results showed SSV significantly reduced doses to the scalp without affecting the radiation exposure to the tumor or surrounding critical structures.
Objective: The clinical behavior of meningiomas is not entirely captured by its designated WHO grade, therefore other factors must be elucidated that portend increased tumor aggressiveness and associated risk of recurrence. In this study, the authors identify multiparametric MRI radiomic signatures of meningiomas using Ki-67 as a prognostic marker of clinical outcomes independent of WHO grade.
Methods: A retrospective analysis was conducted of all resected meningiomas between 2012 and 2018.
Purpose: While the T2-FLAIR mismatch sign is highly specific for isocitrate dehydrogenase (IDH)-mutant, 1p/19q-noncodeleted astrocytomas among lower-grade gliomas, its utility in WHO grade 4 gliomas is not well-studied. We derived the partial T2-FLAIR mismatch sign as an imaging biomarker for IDH mutation in WHO grade 4 gliomas.
Methods: Preoperative MRI scans of adult WHO grade 4 glioma patients (n = 2165) from the multi-institutional ReSPOND (Radiomics Signatures for PrecisiON Diagnostics) consortium were analyzed.