Publications by authors named "Wenyi Zou"
Article Synopsis
- The ALDH2 rs671 genetic variant is prevalent in East Asian populations and is linked to increased cardiovascular disease risk.
- Research reveals that individuals with ALDH2 rs671 mutations exhibit enhanced pro-inflammatory responses in macrophages, contributing to atherosclerosis.
- The study identifies the cGAS-STING pathway as a key player in this process, with ALDH2 promoting the degradation of cGAS, suggesting potential therapeutic targets for atherosclerosis-related cardiovascular disease.
As a newly developed cadmium-free quantum dot (QD), CuInS/ZnS has great application potential in many fields, but its biological safety has not been fully understood. In this study, the in vitro toxicity of CuInS/ZnS QDs on U87 human glioma cell line was explored. The cells were treated with different concentrations of QDs (12.
View Article and Find Full Text PDFPEGylated CuInS/ZnS quantum dots inhibit neurite outgrowth by downregulating the NGF/p75/MAPK pathway.
Ecotoxicol Environ Saf
January 2021
The widespread application of cadmium-free CuInS/ZnS QDs has raised great concern regarding their potential toxicity to humans. To date, toxicological data related to CuInS/ZnS QDs are scarce. Neurons play extraordinary roles in regulating the activities of organs and systems, and serious consequences occur when neurons are damaged.
View Article and Find Full Text PDFGraphene, known as "black gold", has important applications in various fields. In previous studies, it has been proved that graphene oxide (GO) which is a derivative of graphene has low toxicity. However, the immunotoxicity of GO has not been fully elucidated.
View Article and Find Full Text PDFArticle Synopsis
- Cancer stem cells are critical in tumor development and are potential targets for cancer vaccines, but no immunizations exist for them currently.
- Researchers used the OCT4 protein, which is involved in early tumorigenesis, and combined it with keyhole limpet hemocyanin (KLH) and a Toll-like receptor 9 agonist (TLR9) to create a vaccine.
- The OCT4-3 + TLR9 combination showed the strongest immune response and significantly inhibited tumor growth in mice, enhancing cytotoxic T cell activity and various immune-promoting cytokines.
The annual increase in the production and the use of engineering quantum dots (QDs) have led to concern about exposure and safety of QDs. To resolve the risk of Cd release from QDs, a series of Cd-free QDs, represented by CuInS/ZnS QDs, has been developed in recent years. However, the toxicological profile of CuInS/ZnS QDs has not been fully elucidated, especially, their immunotoxicity.
View Article and Find Full Text PDFIn recent years, quantum dots (QDs) have emerged as a potential contrast agent for bioimaging due to their bright luminescence and excellent photostability. However, the wide use of QDs has been limited due to underlying toxicity caused by leakage of heavy metals. Although non-cadmium QDs have been developed to resolve this issue, a comprehensive understanding of the toxicity of these newly developed QDs remains elusive.
View Article and Find Full Text PDFSynergistic antitumor activity of TRAIL combined with chemotherapeutic agents in A549 cell lines in vitro and in vivo.
Cancer Chemother Pharmacol
February 2005
Purpose: To investigate the synergistic cytotoxicity of TRAIL in combination with chemotherapeutic agents in A549 cell lines, we systematically evaluated the cytotoxicity of TRAIL alone and TRAIL in combination with cisplatin, paclitaxel (Taxol) or actinomycin D in A549 cell lines in vitro and in vivo, and whether the sensitivity was correlated with the expression level of TRAIL receptors.
Methods: We investigated the cytotoxicity of TRAIL alone and the synergistic antitumor effects of TRAIL in combination with chemotherapeutic agents in A549 cells by crystal violet staining and FACS in vitro. The expression levels of DR4, DR5, DcR1 and DcR2 were measured in TRAIL-treated and chemotherapeutic agent-treated A549 cells by Western blotting.